ONTOLOGY BROWSER
| Term: | astemizole |
|
| Accession: | CHEBI:2896
|
 browse the term
 view annotations
|
| Definition: | A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position. |
| Synonyms: | exact_synonym: | 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine |
| | related_synonym: | 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole; 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole; Astemison; C28H31FN4O; COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1; InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31); InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N; astemizol; astemizolum |
| | xref_casrn: | 68844-77-9 |
| | xref: | Beilstein:4830190 "Beilstein Registry Number"; ChEMBL:165605 "ChEMBL COMPOUND"; ChemIDplus:68844-77-9 "CAS Registry Number"; DrugBank:68844-77-9 "CAS Registry Number"; DrugBank:DB00637 "DrugBank"; KEGG COMPOUND:68844-77-9 "CAS Registry Number"; KEGG COMPOUND:C06832 "KEGG COMPOUND"; KEGG DRUG:68844-77-9 "CAS Registry Number"; KEGG DRUG:D00234 "KEGG DRUG" |
| | xref_mesh: | MESH:D016589 |
| | xref: | Patent:EP5318 "Patent"; Patent:US4219559 "Patent" |
|
|
| Parent Terms |
Term With Siblings |
Child Terms |
|
|
(+)-N-methylconiine
(2R)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
(2R,4S)-N-\{(1R,2R)-4-[(1H-benzimidazol-2-ylmethyl)amino]-1-benzyl-2-hydroxy-4-oxobutyl\}-2-\{(1R)-2-(benzylamino)-2-oxo-1-[(phenylacetyl)amino]ethyl\}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
(2S)-2-ethylpiperidine
(3R)-3-butylpiperidine
(3R,4R)-4-\{4-[3-(benzyloxy)propoxy]phenyl\}-3-(naphthalen-2-ylmethoxy)piperidine
(5-\{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl\}-2H-1,2,3-triazol-4-yl)methanol
(5S)-5-\{4-[(2S)-2-(1H-benzimidazol-2-yl)-2-(1,3-benzothiazol-2-ylamino)ethyl]phenyl\}isothiazolidin-3-one 1,1-dioxide
(S)-carbinoxamine maleate
1-(1-phenylcyclohexyl)piperidine
1-(2-deoxyribosyl)benzimidazole +
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-4-\{[4-(2-methoxyphenyl)piperidin-1-yl]methyl\}isoquinoline
1-(5-\{[3-(1H-benzimidazol-2-yl)propanoyl]amino\}-5-deoxy-alpha-L-lyxofuranosyl)cytosine
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine
1-erythrosylbenzimidazole +
1-ribosylbenzimidazole +
2''-(4-methoxyphenyl)-5-(3-aminopyrrolidin-1-yl)-2,5',2',5''-ter(benzimidazole)
2',4,4',6'-tetrahydroxychalcone +
2,2'-[propane-1,3-diylbis(piperidine-4,1-diylethane-2,1-diyl)]bis(10-methoxy-7H-pyrido[4,3-c]carbazol-2-ium)
2,2-diphenyl-4-piperidinomethyl-1,3-dioxolane methiodide
2-(4-\{5-[(1H-benzimidazol-2-ylamino)methyl]thiophen-2-yl\}-1,3-thiazol-2-yl)guanidine
2-(beta-D-glucosyl)benzimidazole
2-(piperidin-1-yl)ethanol +
2-[4-(aminomethyl)piperidin-1-yl]-N-(3-cyclohexyl-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl)acetamide
2-[5-(4-carbamimidoylphenyl)furan-2-yl]-1H-benzimidazole-5-carboximidamide
2-aminobenzimidazole +
3-(5-\{[4-(aminomethyl)piperidin-1-yl]methyl\}-1H-indol-2-yl)-1H-indazole-6-carbonitrile
3-(5-\{[4-(aminomethyl)piperidin-1-yl]methyl\}-1H-indol-2-yl)quinolin-2(1H)-one
3-(5-\{[5-(carbamoylamino)-2-oxo-2H-indol-3-yl]methyl\}-1H-pyrrol-3-yl)-N-(2-piperidin-1-ylethyl)benzamide
3-(\{[5-(2-piperidin-4-ylethyl)thieno[2,3-b]thiophen-2-yl]carbonyl\}amino)-N-(pyridin-3-ylsulfonyl)-D-alanine
3-[(7-carbamimidoylnaphthalen-2-yl)methyl]-5-(\{1-[(1Z)-ethanimidoyl]piperidin-4-yl\}oxy)-2-methyl-1H-3,1-benzimidazol-3-ium
3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one
3-\{[2-(1H-benzimidazol-1-yl)-6-\{[2-(diethylamino)ethyl]amino\}pyrimidin-4-yl]amino\}-4-methylphenol
3-cyclohexyl-1-[2-(methyl\{[(3R)-1-methylpiperidin-3-yl]methyl\}amino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxylic acid
3-methylfentanyl
3-methylthiofentanyl +
4-(4-benzyl-4-methoxypiperidin-1-yl)-N-[(4-\{[1,1-dimethyl-2-(phenylsulfanyl)ethyl]amino\}-3-nitrophenyl)sulfonyl]benzamide
4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
4-(4-fluorobenzyl)piperidine
4-(diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]piperidine
4-[3-(4-benzylpiperidin-1-yl)propanoyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
4-chlorophenyl methyl\{trans-4-[4-(piperidin-1-ylmethyl)phenyl]cyclohexyl\}carbamate
4-ethylpiperidine
4-fluorofentanyl
4-piperidin-4-ylbutanal
5'-hydroxyomeprazole
5-[(2-aminobenzimidazol-6-yl)amino]-5-oxopentanoic acid
5-cyano-N-[5-(hydroxymethyl)-2-(4-methylpiperidin-1-yl)phenyl]furan-2-carboxamide
6-\{4-[4-(4-chlorophenyl)piperidin-4-yl]phenyl\}-9H-purine
7-\{[2-(\{1-[(1Z)-ethanimidoyl]piperidin-4-yl\}oxy)-9H-carbazol-9-yl]methyl\}naphthalene-2-carboximidamide
7-epiclusianone
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol +
[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl][3-(piperidin-4-yloxy)phenyl]methanone
albendazole +
alcaftadine
alfentanil
alogliptin
amidopiperidine +
aminopiperidine +
aminopotentidine
amlexanox
aripiprazole
astemizole A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
azatadine +
azatadine maleate
azelastine +
azelastine hydrochloride
azilsartan medoxomil
benomyl
benproperine +
benzimidazole +
benzimidazolecarbaldehyde +
benzimidazolecarboxylic acid +
benzimidazolequinone +
benzquinamide +
benzylpenicillin clemizole
bepotastine
bepotastine besylate
bevonium methyl sulfate
bibenzimidazole +
biperiden +
biperiden hydrochloride
bipiperidines +
bromazine +
bromazine hydrochloride +
brompheniramine +
brompheniramine maleate +
carbendazim
carbinoxamine +
carbinoxamine maleate +
carboxyfentanyl
carfentanyl
cetirizine
CGP 12177
chlorphenamine +
cinnarizine
cisapride
clemastine +
clemastine fumarate
clopenthixol +
cortisol +
cyclizine +
cyclizine hydrochloride
cycrimine +
cyproheptadine +
cyproheptadine hydrochloride sesquihydrate
dabigatran +
dabigatran etexilate
davidigenin
deptropine +
deptropine citrate
desipramine +
desloratadine
desmethyl loperamide
dexbrompheniramine +
dexbrompheniramine maleate
dichotomoside D
dimenhydrinate
dimethylbenzimidazole +
diphemanil methylsulfate
diphenhydramine +
diphenhydramine hydrochloride
diphenhydramine salicylate
diphenidol
diphenylpyraline +
diphenylpyraline hydrochloride
dipyridamole
domperidone +
donepezil +
donepezil hydrochloride
doxylamine
droperidol
dyclonine +
emedastine +
emedastine difumarate
encainide +
epinastine +
esomeprazol +
ethyl piperidinoacetylaminobenzoate
fentanyl +
fexofenadine
flavoxate
fluticasone propionate
fucodiphloroethol G
hesperadin
heteroarylpiperidine +
hydroxypiperidine +
hydroxyzine +
iloperidone
iminopiperidine +
jaceosidin
ketanserin
lansoprazole
lofentanyl
lomitapide
loperamide
loxtidine
lycoperine A
mebendazole
mepyramine
methapyrilene +
methapyrilene hydrochloride
metixene +
mianserin +
miglustat
mirtazapine
mometasone +
mometasone furoate
myricitrin +
N-(1H-benzimidazol-2-yl)-3-[(3-\{3-[(1H-benzimidazol-2-ylamino)carbonyl]benzyl\}-4,7-dibenzyl-5,6-dihydroxy-2-oxo-1,3-diazepan-1-yl)methyl]benzamide
N-[(1S)-1-(1H-benzimidazol-2-yl)-2-\{4-[(5S)-1,1-dioxido-3-oxo-1,2-thiazolidin-5-yl]phenyl\}ethyl]-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide
N-[(4-\{[1,1-dimethyl-2-(phenylthio)ethyl]amino\}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide
N-[2-oxo-3-((E)-phenyl\{[4-(piperidin-1-ylmethyl)phenyl]imino\}methyl)-2,6-dihydro-1H-indol-5-yl]ethanesulfonamide
N-[3-cyano-6-(3-piperidin-1-ylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]naphthalene-1-carboxamide
N-\{(1S)-2-\{4-[(5R)-1,1-dioxido-3-oxo-1,2-thiazolidin-5-yl]phenyl\}-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]ethyl\}-2,2,2-trifluoroacetamide
N-\{(2S,3R)-2-[(1S)-1-formyl-2-methylpropyl]-1-[(2E)-4-piperidin-1-ylbut-2-enoyl]pyrrolidin-3-yl\}methanesulfonamide
N-\{2,2-difluoro-2-[(2R)-piperidin-2-yl]ethyl\}-2-[2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-amine
N-\{[4-(4-phenylpiperidin-1-yl)phenyl]sulfonyl\}-L-tryptophan
N-\{[4-(4-phenylpiperidin-1-yl)phenyl]sulfonyl\}glycine
N-acylpiperidine +
N-carbamimidoylpiperidine +
N-cyclohexylpiperidine +
N-ethylpiperidine +
N-methylfentanyl
N-oxyethylpiperidine +
nedocromil
nocodazole
norfentanyl
omeprazole +
orphenadrine +
orphenadrine citrate
orphenadrine hydrochloride
oxfendazole
pacatal
pantoprazole
pantoprazole(1-) +
paroxetine
perhexiline
phencyclidine
pimobendan
pimozide
piperidine +
piperidine alkaloid +
piperidine antibiotic +
piperidine N-oxide +
piperidinecarboxamide +
piperidinecarboxylate ester +
piperidinemonocarboxylic acid +
piperidinesulfonamide +
piperidone +
promazine +
promethazine
promethazine hydrochloride
rabeprazole
rhinacanthin D
rhodiocyanoside A
risperidone
ritanserin
RS 39604
sappanchalcone
sertindole
spirolucidine
sufentanil
sulfanylpiperidine +
TEMPO +
tenocyclidine
thiabendazole
thienylfentanyl
thioridazine +
tirofiban +
tixocortol pivalate
trazodone +
trazodone hydrochloride
triamcinolone acetonide
vandetanib +
veliparib
zuclopenthixol
|
|
|
|
|
