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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:kinin signaling pathway
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Accession:PW:0001480 term browser browse the term
Definition:The active kinin peptides generated by the kallikrein-kinin cascade - bradykinin, kallidin and their C-terminal processed metabolites, signal via two G-protein coupled (GPCR) receptors. The two receptors employ similar signaling pathways but also exhibit distinct patterns. Type 1 receptor is inducible, type 2 is ubiquitous and can form heterodimers with angiotensin II receptors.

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kinin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO RGD PMID:21145390 RGD:7411621 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:21145390 RGD:7411621 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 PMID:15734727 RGD:7401223, RGD:7401225 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO
TAS
RGD PMID:16177542 PMID:15734727 RGD:7401223, RGD:7401225 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15734727 RGD:7401225 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
JBrowse link
G Kng1 kininogen 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
JBrowse link
G Kng2 kininogen 2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to immunity 793
        kallikrein-kinin cascade pathway 20
          kinin signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to the brain and nervous system 465
        sensory system signaling pathway 79
          kallikrein-kinin cascade pathway 20
            kinin signaling pathway 7
paths to the root