The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
The active kinin peptides generated by the kallikrein-kinin cascade - bradykinin, kallidin and their C-terminal processed metabolites, signal via two G-protein coupled (GPCR) receptors. The two receptors employ similar signaling pathways but also exhibit distinct patterns. Type 1 receptor is inducible, type 2 is ubiquitous and can form heterodimers with angiotensin II receptors.