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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium signaling pathway via the calcium-sensing receptor
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Accession:PW:0001141 term browser browse the term
Definition:Calcium signaling through the calcium-sensing receptor inhibits the secretion of parathyroid hormone in the parathyroid glands and controls calcium absorption and water balance in the kidneys. Calcium is considered the main physiological agonist but other cations and various agonists can activate the receptor. The G protein coupled receptor (GPCR) is believed to engage several types of Galpha proteins and to have many other interacting partners. The pathway leads to activation of MAPK cascades, particularly the one mediated by Erk1/2. Casr signaling is cell specific; many of its molecular details are not fully understood. Many mutations, both inactivating and activating the receptor, have been identified.
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calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO
IMP		 RGD PMID:15637145 PMID:22192592 RGD:7207060, RGD:7207059 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 ISO
IMP		 RGD PMID:15637145 PMID:22192592 RGD:7207060, RGD:7207059 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Casr calcium-sensing receptor IMP
IDA		 RGD PMID:22192592 PMID:15637145 PMID:12239094 RGD:7207059, RGD:7207060, RGD:7207227 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Flna filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:15637145 RGD:7207060 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:15637145 RGD:7207060 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15637145 RGD:7207060 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693 		JBrowse link
G Rgs12 regulator of G-protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chr14:75,715,925...75,824,012
Ensembl chr14:75,715,934...75,794,596 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12239094 RGD:7207227 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G Rhoa ras homolog family member A ISO RGD PMID:12239094 RGD:7207227 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      calcium/calcium-mediated signaling pathway 272
        calcium signaling pathway via the calcium-sensing receptor 12
          altered calcium signaling pathway via the calcium-sensing receptor 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          metal homeostasis pathway 339
            calcium homeostasis pathway 277
              calcium/calcium-mediated signaling pathway 272
                calcium signaling pathway via the calcium-sensing receptor 12
                  altered calcium signaling pathway via the calcium-sensing receptor 0
paths to the root