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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:homocysteine metabolic pathway
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Accession:PW:0000398 term browser browse the term
Definition:Homocysteine (Hcy) metabolism is at the intersection of two pathways: the remethylation pathway that regenerates methionine and thus the methionine cycle and the transsulfuration pathway that gives rise to cysteine and derivatives. The Hcy pathway also engages choline, folate and vitamin metabolism and links to the metabolism of other amino acids and compounds.
Synonyms:related_synonym: Hcy metabolism;   homocysteine metabolic process
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homocysteine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase TAS
ISO		 RGD PMID:11741948 PMID:20814827 RGD:730275, RGD:7242426 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G As3mt arsenite methyltransferase TAS RGD PMID:11790780 RGD:625365 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Asmt acetylserotonin O-methyltransferase NAS RGD PMID:12198599 RGD:1359073 NCBI chr12:16,304,719...16,309,568
Ensembl chr12:16,304,719...16,309,568 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Comt catechol-O-methyltransferase TAS RGD PMID:12584150 RGD:1359089 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Dnmt1 DNA methyltransferase 1 TAS RGD PMID:12473678 RGD:1359078 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase ISO RGD PMID:12628190 RGD:1359080 NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase IDA RGD PMID:15533043 RGD:1359081 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Gnmt glycine N-methyltransferase IDA RGD PMID:15347642 RGD:1359070 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Hnmt histamine N-methyltransferase ISS RGD PMID:11566133 RGD:1359041 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012 		JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase ISS RGD PMID:15625008 RGD:1359083 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128 		JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 ISO RGD PMID:11827451 RGD:1359074 NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Nnmt nicotinamide N-methyltransferase ISO RGD PMID:15922112 RGD:1359084 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655 		JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 IDA RGD PMID:8263531 RGD:729481 NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase IDA RGD PMID:8344945 RGD:729486 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase TAS RGD PMID:12438084 RGD:1359087 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 ISS RGD PMID:15866169 RGD:1359044 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt3 protein arginine methyltransferase 3 ISS RGD PMID:15866169 RGD:1359044 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 ISO RGD PMID:15866169 RGD:1359044 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Prmt6 protein arginine methyltransferase 6 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648 		JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase ISO RGD PMID:11472630 RGD:1359071 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775 		JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:11959841 RGD:1359072 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506 		JBrowse link
G Suv39h2 SUV39H2 histone lysine methyltransferase ISO RGD PMID:11094092 RGD:1359810 NCBI chr17:74,756,290...74,775,332
Ensembl chr17:74,756,306...74,775,332 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 ISO RGD PMID:12794065 RGD:1359088 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439 		JBrowse link
remethylation pathway of homocysteine metabolism - cobalamin dependent term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
ISO		 RGD PMID:15845641 PMID:20814827 RGD:1359026, RGD:7242426 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 PMID:20814827 RGD:1359037, RGD:7242426 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependent term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase ISO SMPDB SMP:00123 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 ISO SMPDB SMP:00123 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase IDA
ISO		 SMPDB
RGD		 PMID:15845641 PMID:20814827 PMID:20346934 SMP:00123, RGD:1359026, RGD:7242426, RGD:7242428 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Chdh choline dehydrogenase ISO SMPDB SMP:00123 NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00123 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB SMP:00123 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB SMP:00123 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase ISO SMPDB SMP:00123 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
transsulfuration pathway of homocysteine metabolism term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase ISO SMPDB
RGD		 PMID:20162368 SMP:00455, RGD:7242427 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Cdo1 cysteine dioxygenase type 1 ISO RGD PMID:20162368 RGD:7242427 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296 		JBrowse link
G Csad cysteine sulfinic acid decarboxylase ISO RGD PMID:20162368 RGD:7242427 NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615 		JBrowse link
G Cth cystathionine gamma-lyase ISO SMPDB
RGD		 PMID:20162368 SMP:00455, RGD:7242427 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
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