PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: hypoxia inducible factor pathway
Accession: PW:0000360
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Definition: The hypoxia inducible transcription factor is activated in response to hypoxic conditions to promote the expression of many genes that play important roles in glucose and energy metabolism, angiogenesis and erythropoiesis.
Synonyms: related_synonym: HIF pathway; Regulation of gene expression by Hypoxia-inducible Factor
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Abcb1a
ATP binding cassette subfamily B member 1A
ISO
PID
PID:200202
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcg2
ATP binding cassette subfamily G member 2
ISO
PID
PID:200036 PID:200202
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Adm
adrenomedullin
ISO
PID
PID:200202
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Adora2a
adenosine A2a receptor
ISO
PID
PID:200036
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200202
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldoa
aldolase, fructose-bisphosphate A
ISO
PID
PID:200202
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Aldoart2
aldolase 1 A retrogene 2
ISO
PID
PID:200202
NCBI chr 6:72,939,821...72,941,511
Ensembl chr 6:72,939,788...72,941,709
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
ISO
PID
PID:200036
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Arnt
aryl hydrocarbon receptor nuclear translocator
ISO
PID RGD
PMID:22169972
PID:200036 PID:200202, RGD:6483352
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Arnt2
aryl hydrocarbon receptor nuclear translocator 2
ISO
RGD
PMID:22169972
RGD:6483352
NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
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Bhlhe40
basic helix-loop-helix family, member e40
ISO
PID
PID:200036 PID:200202
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Bhlhe41
basic helix-loop-helix family, member e41
ISO
PID
PID:200202
NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468
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Bnip3
BCL2 interacting protein 3
ISO
PID
PID:200202
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Car9
carbonic anhydrase 9
ISO
PID
PID:200202
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
ISO
PID
PID:200036 PID:200202
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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Cops5
COP9 signalosome subunit 5
ISO
PID
PID:200202
NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
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Cp
ceruloplasmin
ISO
PID
PID:200202
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Creb1
cAMP responsive element binding protein 1
ISO
PID
PID:200202
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Crebbp
CREB binding protein
ISO
PID RGD
PMID:19364912 PMID:20396958
PID:200036 PID:200202, RGD:6483358 , RGD:6483503
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Cul2
cullin 2
ISO
RGD
PMID:19364912
RGD:6483358
NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968
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Cxcl12
C-X-C motif chemokine ligand 12
ISO
PID
PID:200202
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcr4
C-X-C motif chemokine receptor 4
ISO
PID
PID:200202
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Edn1
endothelin 1
ISO
PID
PID:200202
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Efna1
ephrin A1
ISO
PID
PID:200036
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
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Egln1
egl-9 family hypoxia-inducible factor 1
IDA ISO TAS
PID RGD
PMID:12876291 PMID:20396958 PMID:19364912 PMID:14597660
PID:200036 PID:200202, RGD:727754 , RGD:6483503 , RGD:6483358 , RGD:1334466
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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Egln2
egl-9 family hypoxia-inducible factor 2
ISO
PID RGD
PMID:20396958
PID:200036, RGD:6483503
NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751
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Egln3
egl-9 family hypoxia-inducible factor 3
ISO
PID RGD
PMID:20396958
PID:200036 PID:200202, RGD:6483503
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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Eif3e
eukaryotic translation initiation factor 3 subunit E
ISO
PID
PID:200036
NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
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Elk1
ETS transcription factor ELK1
ISO
PID
PID:200036
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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Elob
elongin B
ISO
PID RGD
PMID:19364912
PID:200036, RGD:6483358
NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635
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Eloc
elongin C
ISO
PID RGD
PMID:19364912
PID:200036, RGD:6483358
NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890
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Eng
endoglin
ISO
PID
PID:200202
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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Eno1
enolase 1
ISO
PID
PID:200202
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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Ep300
E1A binding protein p300
ISO
PID RGD
PMID:19364912 PMID:20396958
PID:200036 PID:200202, RGD:6483358 , RGD:6483503
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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Epas1
endothelial PAS domain protein 1
ISO
PID RGD
PMID:22169972 PMID:20396958
PID:200036, RGD:6483352 , RGD:6483503
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Epo
erythropoietin
ISO
PID
PID:200036 PID:200202
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Ets1
ETS proto-oncogene 1, transcription factor
ISO
PID
PID:200036 PID:200202
NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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Fech
ferrochelatase
ISO
PID
PID:200202
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Flt1
Fms related receptor tyrosine kinase 1
ISO
PID
PID:200036
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200202
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Furin
furin (paired basic amino acid cleaving enzyme)
ISO
PID
PID:200202
NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
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Fxn
frataxin
ISO
PID
PID:200036
NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
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Gata2
GATA binding protein 2
ISO
PID
PID:200202
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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Gck
glucokinase
ISO
PID
PID:200202
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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Hdac7
histone deacetylase 7
ISO
PID
PID:200202
NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
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Hif1a
hypoxia inducible factor 1 subunit alpha
IDA ISO
PID RGD
PMID:12388599 PMID:20396958 PMID:22169972 PMID:18614764 PMID:15063765
PID:200202, RGD:628389 , RGD:6483503 , RGD:6483352 , RGD:2301848 , RGD:1580561
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hif1an
hypoxia inducible factor 1 subunit alpha inhibitor
ISO
PID RGD
PMID:14597660 PMID:19364912 PMID:22169972
PID:200036, RGD:1334466 , RGD:6483358 , RGD:6483352
NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
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Hif3a
hypoxia inducible factor 3 subunit alpha
TAS ISO
RGD
PMID:11237857 PMID:22169972
RGD:68201 , RGD:6483352
NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
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Hk1
hexokinase 1
ISO
PID
PID:200202
NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
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Hk2
hexokinase 2
ISO
PID
PID:200202
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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Hmox1
heme oxygenase 1
ISO
PID
PID:200202
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hnf4a
hepatocyte nuclear factor 4, alpha
ISO
PID
PID:200202
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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Id2
inhibitor of DNA binding 2
ISO
PID
PID:200202
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Igfbp1
insulin-like growth factor binding protein 1
ISO
PID
PID:200202
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Itgb2
integrin subunit beta 2
ISO
PID
PID:200202
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200202
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kdr
kinase insert domain receptor
ISO
PID
PID:200036
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Ldha
lactate dehydrogenase A
ISO
PID
PID:200202
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Lep
leptin
ISO
PID
PID:200202
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
ISO
PID
PID:200202
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mmp14
matrix metallopeptidase 14
ISO
PID
PID:200036
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Ncoa1
nuclear receptor coactivator 1
ISO
PID
PID:200202
NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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Ncoa2
nuclear receptor coactivator 2
ISO
PID
PID:200202
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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Ndrg1
N-myc downstream regulated 1
ISO
PID
PID:200202
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Nos2
nitric oxide synthase 2
ISO
PID
PID:200202
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Npm1
nucleophosmin 1
ISO
PID
PID:200202
NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
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Nt5e
5' nucleotidase, ecto
ISO
PID
PID:200202
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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Os9
OS9, endoplasmic reticulum lectin
ISO
RGD
PMID:19364912
RGD:6483358
NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745
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Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
ISO
PID
PID:200202
NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
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Pfkl
phosphofructokinase, liver type
ISO
PID
PID:200202
NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315
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Pgk1
phosphoglycerate kinase 1
ISO
PID
PID:200036 PID:200202
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Pgm1
phosphoglucomutase 1
ISO
PID
PID:200202
NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
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Pkm
pyruvate kinase M1/2
ISO
PID
PID:200202
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Plin2
perilipin 2
ISO
PID
PID:200202
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Pou5f1
POU class 5 homeobox 1
ISO
PID
PID:200036
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Rack1
receptor for activated C kinase 1
ISO
RGD
PMID:19364912
RGD:6483358
NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
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Rbx1
ring-box 1
ISO
RGD
PMID:19364912
RGD:6483358
NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
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Sat1
spermidine/spermine N1-acetyl transferase 1
ISO
RGD
PMID:19364912
RGD:6483358
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Sat2
spermidine/spermine N1-acetyltransferase family member 2
ISO
RGD
PMID:19364912
RGD:6483358
NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224
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Serpine1
serpin family E member 1
ISO
PID
PID:200036 PID:200202
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Sirt1
sirtuin 1
ISO
PID
PID:200036
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc11a2
solute carrier family 11 member 2
ISO
PID
PID:200036
NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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Slc2a1
solute carrier family 2 member 1
ISO
PID
PID:200036 PID:200202
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Smad3
SMAD family member 3
ISO
PID
PID:200202
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smad4
SMAD family member 4
ISO
PID
PID:200202
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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Sp1
Sp1 transcription factor
ISO
PID
PID:200036 PID:200202
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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Tert
telomerase reverse transcriptase
ISO
PID
PID:200202
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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Tf
transferrin
ISO
PID
PID:200202
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
G
Tff3
trefoil factor 3
ISO
PID
PID:200202
NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
G
Tfrc
transferrin receptor
ISO
PID
PID:200202
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Twist1
twist family bHLH transcription factor 1
ISO
PID
PID:200036
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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Vegfa
vascular endothelial growth factor A
ISO
PID
PID:200036 PID:200202
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vhl
von Hippel-Lindau tumor suppressor
ISO IDA
PID RGD
PMID:15611513 PMID:15063765 PMID:19364912
PID:200036, RGD:1358257 , RGD:1580561 , RGD:6483358
NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
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Vhl
von Hippel-Lindau tumor suppressor
ISO
RGD
PMID:22035299
RGD:6907133
NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all