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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tumor necrosis factor mediated signaling pathway
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Accession:PW:0000233 term browser browse the term
Definition:Tumor necrosis factor (Tnf) signaling plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis by activating several pathways. NF-kB is a major pathway activated by Tnf; others include JNK and P38 MAPK. Through receptor-associated adapters, Tnf elicits apoptosis via the extrinsic pathway. Deregulation of Tnf signaling has been implicated in a great number of human diseases - cerebral malaria, cancer and multiple sclerosis are a few examples.
Synonyms:related_synonym: TNF signaling;   TNF signaling pathway;   TNFalpha signaling pathway;   tumor necrosis factor-mediated signaling pathway
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tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Bag4 BAG cochaperone 4 ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO PID
RGD		 PMID:23085193 PID:200102, RGD:7800730 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO PID
RGD		 PMID:23085193 PID:200102, RGD:7800730 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp8 caspase 8 ISO PID PID:200102 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cav1 caveolin 1 ISO PID PID:200102 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO PID
RGD		 PMID:23312890 PMID:21119682 PID:200102, RGD:7800734, RGD:7800735 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Madd MAP-kinase activating death domain ISO PID PID:200102 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO PID PID:200102 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200102 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200102 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO PID PID:200102 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 ISO PID PID:200102 NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 ISO PID PID:200102 NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ISO PID PID:200102 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698 		JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 6:88,284,087...88,377,118
Ensembl chr 6:88,284,094...88,376,799 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200102 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nrk Nik related kinase ISO PID PID:200102 NCBI chr  X:102,365,765...102,462,957
Ensembl chr  X:102,365,765...102,459,657 		JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor ISO PID PID:200102 NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627 		JBrowse link
G Prkci protein kinase C, iota ISO PID PID:200102 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200102 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO PID PID:200102 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID PID:200102 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ISO PID PID:200102 NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID
RGD		 PMID:12655295 PMID:23085193 PID:200102, RGD:2292150, RGD:7800730 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rnf11 ring finger protein 11 ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 5:124,212,433...124,243,125
Ensembl chr 5:124,212,445...124,234,750 		JBrowse link
G Rnf31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915 		JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200102 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 ISO PID PID:200102 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Sqstm1 sequestosome 1 ISO PID PID:200102 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200102 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:49,972,414...50,044,658
Ensembl chr  X:49,972,330...50,042,056 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Tnf tumor necrosis factor ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO
IMP		 PID
RGD		 PMID:12655295 PMID:20967881 PID:200102, RGD:2292150, RGD:5130945 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO PID PID:200102 NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750 		JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 ISO PID PID:200102 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO
IMP		 PID
RGD		 PMID:12655295 PMID:20967881 PMID:23085193 PID:200102, RGD:2292150, RGD:5130945, RGD:7800730 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf5 TNF receptor-associated factor 5 ISO RGD PMID:23085193 RGD:7800730 NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709 		JBrowse link
G Txn1 thioredoxin 1 ISO PID PID:200102 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      cytokine and chemokine mediated signaling pathway 570
        cytokine mediated signaling pathway 485
          tumor necrosis factor superfamily mediated signaling pathway 88
            tumor necrosis factor mediated signaling pathway 54
              altered tumor necrosis factor mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      cell death pathway 243
        programmed cell death pathway 243
          apoptotic cell death pathway 162
            extrinsic apoptotic pathway 88
              tumor necrosis factor mediated signaling pathway 54
                altered tumor necrosis factor mediated signaling pathway 0
paths to the root