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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:non-homologous end joining pathway of double-strand break repair
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Accession:PW:0000203 term browser browse the term
Definition:A specific pathway for repair of double-strand breaks. Possibly constitutive, it is the most important pathway in mammalian cells and plays an important role in mitotically replicating cells.
Synonyms:related_synonym: NHEJ pathway of double-strand break repair;   Nonhomologous End-Joining (NHEJ);   double-strand break repair via nonhomologous end joining
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non-homologous end joining pathway of double-strand break repair term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor ISO RGD PMID:20192759 RGD:8662352 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Aptx aprataxin ISO RGD PMID:20192759 RGD:8662352 NCBI chr 5:55,798,896...55,822,963
Ensembl chr 5:55,800,248...55,822,855 		JBrowse link
G Dclre1c DNA cross-link repair 1C IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Dntt DNA nucleotidylexotransferase IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr 1:239,856,391...239,888,283
Ensembl chr 1:239,856,391...239,888,282 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 IEA KEGG rno:03450 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Lig4 DNA ligase 4 IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease IEA KEGG rno:03450 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Pnkp polynucleotide kinase 3'-phosphatase ISO RGD PMID:20192759 RGD:8662352 NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920 		JBrowse link
G Poll DNA polymerase lambda IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662 		JBrowse link
G Polm DNA polymerase mu IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO RGD PMID:20192759 RGD:8662352 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rad50 RAD50 double strand break repair protein IEA KEGG rno:03450 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease ISO RGD PMID:19633668 RGD:401940172 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rif1 replication timing regulatory factor 1 ISO RGD PMID:24326623 RGD:8661237 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 ISO RGD PMID:24326623 RGD:8661237 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 IEA
ISO		 KEGG
RGD		 PMID:20192759 rno:03450, RGD:8662352 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1752
        DNA repair pathway 384
          double-strand DNA repair pathway 48
            non-homologous end joining pathway of double-strand break repair 19
              altered non-homologous end joining pathway of double-strand break repair 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1752
        DNA damage response pathway 405
          DNA repair pathway 384
            double-strand DNA repair pathway 48
              non-homologous end joining pathway of double-strand break repair 19
                altered non-homologous end joining pathway of double-strand break repair 0
paths to the root