ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic pathway
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Accession:PW:0000104 term browser browse the term
Definition:The apoptotic pathway involving organelles, primarily the mitochondrion and endoplasmic reticulum (ER), and involving the pro and anti-apoptotic members of the Bcl family of proteins, cytochrome c, formation of the apoptosome and activation of caspases.
Comment:The reference was compiled based on the information available in the cited article.
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intrinsic apoptotic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Apaf1 apoptotic peptidase activating factor 1 GBrowse link IEP 7 27,932,908 28,020,533 RGD:2313998 RGD
G Bad BCL2-associated agonist of cell death GBrowse link ISS 1 209,617,373 209,626,292 RGD:2314029 RGD
G Bad BCL2-associated agonist of cell death GBrowse link ISS 1 209,617,373 209,626,292 RGD:1579966 RGD
G Bad_v1 BCL2-associated agonist of cell death, variant 1 ISS RGD:1579966 RGD
G Bad_v2 BCL2-associated agonist of cell death, variant 2 ISS RGD:1579966 RGD
G Bak1 BCL2-antagonist/killer 1 GBrowse link ISS 20 5,255,954 5,264,593 RGD:2313975 RGD
G Bak1 BCL2-antagonist/killer 1 GBrowse link IMP 20 5,255,954 5,264,593 RGD:2313963 RGD
G Bax Bcl2-associated X protein GBrowse link IEP 1 95,933,023 95,938,176 RGD:2313998 RGD
G Bax Bcl2-associated X protein GBrowse link IEP 1 95,933,023 95,938,176 RGD:2314140 RGD
G Bax Bcl2-associated X protein GBrowse link ISS 1 95,933,023 95,938,176 RGD:1579966 RGD
G Bax Bcl2-associated X protein GBrowse link ISS 1 95,933,023 95,938,176 RGD:2313975 RGD
G Bax Bcl2-associated X protein GBrowse link IMP 1 95,933,023 95,938,176 RGD:2313963 RGD
G Bax_v1 bcl2-associated X protein, variant 1 ISS RGD:1579966 RGD
G Bax_v2 bcl2-associated X protein, variant 2 ISS RGD:1579966 RGD
G Bbc3 Bcl-2 binding component 3 IDA RGD:2313994 RGD
G Bbc3 Bcl-2 binding component 3 ISS RGD:2314029 RGD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link IEP 13 12,730,736 12,905,108 RGD:2313998 RGD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link IEP 13 12,730,736 12,905,108 RGD:2314140 RGD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link ISS 13 12,730,736 12,905,108 RGD:1579966 RGD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link ISS 13 12,730,736 12,905,108 RGD:2313975 RGD
G Bcl2a1 BCL2-related protein A1 GBrowse link ISS 8 94,045,109 94,053,777 RGD:2313975 RGD
G Bcl2l1 Bcl2-like 1 GBrowse link IEP 3 143,129,087 143,180,199 RGD:2314140 RGD
G Bcl2l1 Bcl2-like 1 GBrowse link ISS 3 143,129,087 143,180,199 RGD:1579966 RGD
G Bcl2l1 Bcl2-like 1 GBrowse link ISS 3 143,129,087 143,180,199 RGD:2313975 RGD
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) GBrowse link ISS 3 115,692,323 115,722,701 RGD:2314029 RGD
G Bcl2l2 Bcl2-like 2 GBrowse link ISS 15 32,983,165 32,988,018 RGD:2313975 RGD
G Bcl2l2 Bcl2-like 2 GBrowse link IMP 15 32,983,165 32,988,018 RGD:2313963 RGD
G Bid BH3 interacting domain death agonist GBrowse link IEP 4 157,296,383 157,318,481 RGD:2313998 RGD
G Bid BH3 interacting domain death agonist GBrowse link ISS 4 157,296,383 157,318,481 RGD:2314029 RGD
G Bid BH3 interacting domain death agonist GBrowse link IEP 4 157,296,383 157,318,481 RGD:2314002 RGD
G Bik BCL2-interacting killer (apoptosis-inducing) GBrowse link ISS 7 121,377,004 121,396,609 RGD:2314029 RGD
G Bmf Bcl2 modifying factor GBrowse link ISS 3 104,966,652 104,984,752 RGD:2314029 RGD
G Bnip1 BCL2/adenovirus E1B interacting protein 1 GBrowse link IEP 10 16,648,619 16,660,896 RGD:634759 RGD
G Bnip1 BCL2/adenovirus E1B interacting protein 1 GBrowse link ISS 10 16,648,619 16,660,896 RGD:2314029 RGD
G Bnip3 BCL2/adenovirus E1B interacting protein 3 GBrowse link IDA 1 198,683,009 198,700,075 RGD:2314028 RGD
G Bnip3 BCL2/adenovirus E1B interacting protein 3 GBrowse link ISS 1 198,683,009 198,700,075 RGD:2314029 RGD
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like GBrowse link ISS 15 46,516,626 46,539,756 RGD:2314029 RGD
G Bok BCL2-related ovarian killer GBrowse link IDA 9 92,970,069 92,980,974 RGD:70678 RGD
G Bok BCL2-related ovarian killer GBrowse link ISS 9 92,970,069 92,980,974 RGD:2313975 RGD
G Casp3 caspase 3 GBrowse link IEP 16 48,944,226 48,962,420 RGD:2313998 RGD
G Casp3 caspase 3 GBrowse link IMP 16 48,944,226 48,962,420 RGD:2314002 RGD
G Casp3 caspase 3 GBrowse link TAS 16 48,944,226 48,962,420 RGD:71121 RGD
G Casp3 caspase 3 GBrowse link ISS 16 48,944,226 48,962,420 RGD:2314187 RGD
G Casp3 caspase 3 GBrowse link IMP 16 48,944,226 48,962,420 RGD:2313963 RGD
G Casp3 caspase 3 GBrowse link IMP 16 48,944,226 48,962,420 RGD:2314390 RGD
G Casp7 caspase 7 GBrowse link ISS 1 262,689,300 262,721,591 RGD:2314187 RGD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link IEP 5 160,704,234 160,721,796 RGD:2313998 RGD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link IMP 5 160,704,234 160,721,796 RGD:2314002 RGD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link ISS 5 160,704,234 160,721,796 RGD:2314187 RGD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link IMP 5 160,704,234 160,721,796 RGD:2313963 RGD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link IMP 5 160,704,234 160,721,796 RGD:2314390 RGD
G Cycs cytochrome c, somatic GBrowse link IEP 4 78,825,878 78,827,978 RGD:2313998 RGD
G Cycs cytochrome c, somatic GBrowse link IMP 4 78,825,878 78,827,978 RGD:2313963 RGD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link IEP 1 238,259,443 238,274,745 RGD:1626509 RGD
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) GBrowse link IMP 12 39,520,265 39,543,901 RGD:2290488 RGD
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) GBrowse link IMP 12 39,520,265 39,543,901 RGD:70327 RGD
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) GBrowse link ISS 12 39,520,265 39,543,901 RGD:2314029 RGD
G Htra2 HtrA serine peptidase 2 GBrowse link IMP 4 117,262,206 117,265,368 RGD:2314385 RGD
G Mcl1 myeloid cell leukemia sequence 1 IDA RGD:70678 RGD
G Mcl1 myeloid cell leukemia sequence 1 ISS RGD:2313975 RGD
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link ISS 18 62,914,845 62,918,832 RGD:2314029 RGD
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link IEP 18 62,914,845 62,918,832 RGD:2314140 RGD
G Xiap X-linked inhibitor of apoptosis GBrowse link IMP X 3,011,520 3,047,798 RGD:2314390 RGD
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  Pathway Ontology 17140
    regulatory pathway 5692
      cell death pathway 396
        apoptotic cell death pathway 301
          intrinsic apoptotic pathway 63
            altered intrinsic apoptotic pathway 0
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