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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:intrinsic apoptotic pathway
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Accession:PW:0000104 term browser browse the term
Definition:The apoptotic pathway involving organelles, primarily the mitochondrion and endoplasmic reticulum (ER), and involving the pro- and anti-apoptotic members of the Bcl family of proteins, cytochrome C, formation of the apoptosome and activation of caspases.
Comment:The reference was compiled based on the information available in the cited article.
Synonyms:related_synonym: Intrinsic Pathway for Apoptosis;   intrinsic apoptotic signaling pathway
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intrinsic apoptotic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 IEP RGD PMID:18931364 RGD:2313998 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO
ISS		 RGD PMID:15632274 PMID:19641503 PMID:15632274 RGD:1579966, RGD:2314029, RGD:1579966 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 IMP
ISO		 RGD PMID:18817839 PMID:17322918 RGD:2313963, RGD:2313975 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO
IMP
IEP		 RGD PMID:15632274 PMID:18817839 PMID:17322918 PMID:18931364 PMID:18959742 RGD:1579966, RGD:2313963, RGD:2313975, RGD:2313998, RGD:2314140 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bax_v1 BCL2 associated X, apoptosis regulator, variant 1 ISS RGD PMID:15632274 RGD:1579966
G Bax_v2 BCL2 associated X, apoptosis regulator, variant 2 ISS RGD PMID:15632274 RGD:1579966
G Bbc3 Bcl-2 binding component 3 IDA
ISO		 RGD PMID:19095966 PMID:19641503 RGD:2313994, RGD:2314029 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO
IEP		 RGD PMID:15632274 PMID:17322918 PMID:18931364 PMID:18959742 RGD:1579966, RGD:2313975, RGD:2313998, RGD:2314140 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 ISO RGD PMID:17322918 RGD:2313975 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 ISO
IEP		 RGD PMID:15632274 PMID:17322918 PMID:18959742 RGD:1579966, RGD:2313975, RGD:2314140 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 ISO RGD PMID:17322918 RGD:2313975 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl2l11 Bcl2-like 11 ISO RGD PMID:19641503 RGD:2314029 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 IMP
ISO		 RGD PMID:18817839 PMID:17322918 RGD:2313963, RGD:2313975 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bid BH3 interacting domain death agonist IEP
ISO		 RGD PMID:18931364 PMID:18090083 PMID:19641503 RGD:2313998, RGD:2314002, RGD:2314029 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bik BCL2-interacting killer ISO RGD PMID:19641503 RGD:2314029 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Bmf Bcl2 modifying factor ISO RGD PMID:19641503 RGD:2314029 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145 		JBrowse link
G Bnip1 BCL2 interacting protein 1 IEP
ISO		 RGD PMID:12714334 PMID:19641503 RGD:634759, RGD:2314029 NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157 		JBrowse link
G Bnip3 BCL2 interacting protein 3 TAS
ISO		 RGD PMID:14972662 PMID:19641503 RGD:2314028, RGD:2314029 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO RGD PMID:19641503 RGD:2314029 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK IDA
ISO		 RGD PMID:9356461 PMID:17322918 RGD:70678, RGD:2313975 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp3 caspase 3 IMP
IEP
ISO		 RGD PMID:18817839 PMID:18931364 PMID:18090083 PMID:17082813 PMID:17869439 RGD:2313963, RGD:2313998, RGD:2314002, RGD:2314187, RGD:2314390 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:17082813 RGD:2314187 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 IMP
IEP
ISO		 RGD PMID:18817839 PMID:18931364 PMID:18090083 PMID:17082813 PMID:17869439 RGD:2313963, RGD:2313998, RGD:2314002, RGD:2314187, RGD:2314390 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic IMP
IEP		 RGD PMID:18817839 PMID:18931364 RGD:2313963, RGD:2313998 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Fas Fas cell surface death receptor IEP germ cells RGD PMID:17195944 RGD:1626509 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Hrk harakiri, BCL2 interacting protein IMP
ISO		 RGD PMID:10075695 PMID:17428807 PMID:19641503 RGD:70327, RGD:2290488, RGD:2314029 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Htra2 HtrA serine peptidase 2 IMP RGD PMID:16978742 RGD:2314385 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member IDA
ISO		 RGD PMID:9356461 PMID:17322918 RGD:70678, RGD:2313975 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO
IEP		 RGD PMID:19641503 PMID:18959742 RGD:2314029, RGD:2314140 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Xiap X-linked inhibitor of apoptosis IMP RGD PMID:17869439 RGD:2314390 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      cell death pathway 243
        programmed cell death pathway 243
          apoptotic cell death pathway 162
            intrinsic apoptotic pathway 30
              altered intrinsic apoptotic pathway 0
paths to the root