ONTOLOGY REPORT - ANNOTATIONS

Term:Cervical Intraepithelial Neoplasia
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Accession:RDO:0007165 term browser browse the term
Definition:A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Synonyms:exact_synonym: Cervical Intraepithelial Neoplasia, Grade III;   Cervical Intraepithelial Neoplasm;   Cervical Intraepithelial Neoplasms
 primary_id: MESH:D018290

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Cervical Intraepithelial Neoplasia term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adam9 ADAM metallopeptidase domain 9 GBrowse link ISS 16 71,446,498 71,526,108 RGD:2325246 RGD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link Disease_progression ISS 13 12,730,736 12,905,108 RGD:2298889 RGD
G Brca1 breast cancer 1, early onset GBrowse link ISS 10 90,513,630 90,572,676 RGD:2298942 RGD
G Cadm1 cell adhesion molecule 1 GBrowse link Severity ISS 8 50,765,645 51,108,962 RGD:2289089 RGD
G Ccnd1 cyclin D1 GBrowse link ISS 1 205,357,235 205,366,757 RGD:2293574 RGD
G Ccne1 cyclin E1 GBrowse link ISS 1 90,568,189 90,577,426 RGD:2293574 RGD
G Ccng1 cyclin G1 GBrowse link ISS 10 25,776,380 25,782,754 RGD:2316022 RGD
G Cd46 CD46 molecule, complement regulatory protein GBrowse link ISS 13 110,972,812 111,003,407 RGD:2293549 RGD
G Cdh1 cadherin 1 GBrowse link ISS 19 36,442,693 36,512,091 RGD:2289490 RGD
G Cdk4 cyclin-dependent kinase 4 Disease_progression ISS RGD:2293574 RGD
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link Disease_progression ISS 4 171,841,705 171,846,506 RGD:2293574 RGD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link ISS 5 108,908,749 108,916,380 RGD:2296054 RGD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link ISS 5 108,908,749 108,916,380 RGD:2289675 RGD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link ISS 5 108,908,749 108,916,380 RGD:2289676 RGD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link Disease_progression ISS 5 108,908,749 108,916,380 RGD:2296058 RGD
G Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 ISS RGD:2289675 RGD
G Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 ISS RGD:2289676 RGD
G Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) GBrowse link ISS 5 108,939,669 108,945,293 RGD:2289695 RGD
G Csf1r colony stimulating factor 1 receptor GBrowse link Disease_progression ISS 18 57,080,324 57,107,295 RGD:2299119 RGD
G Ctnna1 catenin (cadherin-associated protein), alpha 1, 102kDa GBrowse link Disease_progression ISS 18 27,629,915 27,769,360 RGD:2289797 RGD
G Faslg Fas ligand (TNF superfamily, member 6) GBrowse link ISS 13 77,472,950 77,480,210 RGD:2290052 RGD
G Hdac1 histone deacetylase 1 GBrowse link ISS 5 148,672,515 148,699,810 RGD:2306200 RGD
G Hdac2 histone deacetylase 2 GBrowse link ISS 20 41,162,093 41,186,492 RGD:2306200 RGD
G Hdac6 histone deacetylase 6 GBrowse link ISS X 26,585,852 26,606,999 RGD:2306200 RGD
G Igfbp3 insulin-like growth factor binding protein 3 GBrowse link ISS 14 87,959,153 87,967,085 RGD:2290021 RGD
G Igfbp3 insulin-like growth factor binding protein 3 GBrowse link ISS 14 87,959,153 87,967,085 RGD:2290004 RGD
G Mgp matrix Gla protein GBrowse link ISS 4 173,910,595 173,913,917 RGD:2293584 RGD
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link ISS 8 115,616,396 115,653,471 RGD:2293515 RGD
G Mmp2 matrix metallopeptidase 2 GBrowse link Disease_progression ISS 19 15,246,036 15,275,061 RGD:2290402 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISS 6 11,199,906 11,258,350 RGD:2293515 RGD
G Phb prohibitin ISS RGD:2292398 RGD
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:2298701 RGD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link Disease_progression ISS 13 64,427,288 64,432,978 RGD:2299119 RGD
G Rb1 retinoblastoma 1 GBrowse link ISS 15 53,828,881 53,962,099 RGD:2299896 RGD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link Disease_progression ISS 1 208,262,669 208,273,148 RGD:2298759 RGD
G RT1-Db1 RT1 class II, locus Db1 GBrowse link ISS 20 4,671,489 4,681,058 RGD:2306230 RGD
G RT1-Db1 RT1 class II, locus Db1 GBrowse link ISS 20 4,671,489 4,681,058 RGD:2306232 RGD
G RT1-Db1 RT1 class II, locus Db1 GBrowse link ISS 20 4,671,489 4,681,058 RGD:2314703 RGD
G Skp2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase GBrowse link Severity ISS 2 58,769,164 58,797,229 RGD:2315036 RGD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link Disease_progression ISS 10 89,821,078 89,872,970 RGD:2298536 RGD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link ISS 10 89,821,078 89,872,970 RGD:2291916 RGD
G Terc telomerase RNA component GBrowse link Disease_progression ISS 2 117,234,446 117,234,833 RGD:2291968 RGD
G Tert telomerase reverse transcriptase GBrowse link Disease_progression ISS 1 30,445,180 30,465,942 RGD:2291985 RGD
G Thrb thyroid hormone receptor beta GBrowse link ISS 15 9,282,845 9,345,506 RGD:2315099 RGD
G Tlr9 toll-like receptor 9 Disease_progression ISS RGD:2301099 RGD
G Top2a topoisomerase (DNA) II alpha GBrowse link ISS 10 87,771,337 87,800,960 RGD:2315126 RGD
G Tp63 tumor protein p63 GBrowse link Disease_progression ISS 11 76,900,622 77,200,251 RGD:2315435 RGD
G Tp73 tumor protein p73 GBrowse link Disease_progression ISS 5 170,848,979 171,078,739 RGD:2290589 RGD
G Vegfa vascular endothelial growth factor A GBrowse link ISS 9 10,520,730 10,536,071 RGD:2315456 RGD
G Xiap X-linked inhibitor of apoptosis GBrowse link ISS X 3,011,520 3,047,798 RGD:2315850 RGD
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  Diseases 30466
    Neoplasms 5206
      Neoplasms by Histologic Type 1785
        Neoplasms, Glandular and Epithelial 1130
          Carcinoma 931
            Carcinoma in Situ 119
              Cervical Intraepithelial Neoplasia 50
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