Graves Disease - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	Graves Disease	go back to main search page
Accession:	RDO:0005703	browse the term
Definition:	A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
Synonyms:	exact_synonym:	Basedow Disease; Basedow's Disease; Basedows Disease; Exophthalmic Goiter; Exophthalmic Goiters; GRAVES DISEASE, SUSCEPTIBILITY TO, 2; GRD; GRD1; GRD2; HYPERTHYROIDISM, AUTOIMMUNE GRAVES DISEASE, SUSCEPTIBILITY TO, 1; Hyperthyroidism, Autoimmune; THYROTOXICOSIS
	primary_id:	MESH:D006111
	alt_id:	OMIM:139200; OMIM:275000; OMIM:603372; OMIM:603388

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Graves Disease
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Adipoq	adiponectin, C1Q and collagen domain containing			ISS	11	79,908,291	79,911,065	RGD:5686857	RGD
G	Adipoq	adiponectin, C1Q and collagen domain containing		Severity	ISS	11	79,908,291	79,911,065	RGD:5686818	RGD
G	C4a	complement component 4A (Rodgers blood group)			ISS	20	4,106,123	4,145,904	RGD:5688264	RGD
G	C4b	complement component 4B (Chido blood group)			ISS	20	4,300,687	4,315,882	RGD:5688264	RGD
G	Ctla4	cytotoxic T-lymphocyte-associated protein 4		No_Association	ISS	9	59,495,773	59,501,300	RGD:2302000	RGD
G	Ctla4	cytotoxic T-lymphocyte-associated protein 4			ISS	9	59,495,773	59,501,300	RGD:2302001	RGD
G	Ctla4	cytotoxic T-lymphocyte-associated protein 4			ISS	9	59,495,773	59,501,300	RGD:1300388	RGD
G	Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1			ISS	8	61,462,207	61,468,237	RGD:5147671	RGD
G	Fkbp1b	FK506 binding protein 1b			ISS				RGD:1580387	RGD
G	Gc	group specific component		Susceptibility	ISS	14	20,166,243	20,197,060	RGD:5509883	RGD
G	Gc	group specific component		Susceptibility	ISS	14	20,166,243	20,197,060	RGD:5509886	RGD
G	Gc	group specific component			ISS	14	20,166,243	20,197,060	RGD:7240710	OMIM
G	Igf1r	insulin-like growth factor 1 receptor			ISS	1	122,704,976	122,990,007	RGD:5686433	RGD
G	Il3	interleukin 3			ISS	10	39,684,691	39,687,041	RGD:5686901	RGD
G	Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)			ISS	2	199,083,186	199,144,309	RGD:6484538	RGD
G	Stat4	signal transducer and activator of transcription 4			ISS	9	46,510,251	46,650,076	RGD:7207875	RGD
G	Tshr	thyroid stimulating hormone receptor			ISS	6	115,024,999	115,162,531	RGD:7240710	OMIM
G	Vdr	vitamin D (1,25- dihydroxyvitamin D3) receptor			IEA	7	136,567,614	136,617,280	RGD:1331525	RGD
Graves Ophthalmopathy
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Il3	interleukin 3			ISS	10	39,684,691	39,687,041	RGD:5686901	RGD
THYROTOXIC PERIODIC PARALYSIS, SUSCEPTIBILITY TO, 1
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit			ISS				RGD:7240710	OMIM

Term paths to the root

Path 1
Term	Annotations
Diseases	30466
Immune System Diseases	3079
Autoimmune Diseases	1548
Graves Disease	20
GRAVES DISEASE, SUSCEPTIBILITY TO, X-LINKED 1	0
Graves Ophthalmopathy	1
THYROTOXIC PERIODIC PARALYSIS, SUSCEPTIBILITY TO, 1	1
Path 2
Term	Annotations
Diseases	30466
Eye Diseases	1054
Orbital Diseases	21
Exophthalmos	21
Graves Disease	20
GRAVES DISEASE, SUSCEPTIBILITY TO, X-LINKED 1	0
Graves Ophthalmopathy	1
THYROTOXIC PERIODIC PARALYSIS, SUSCEPTIBILITY TO, 1	1