Glioblastoma - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	Glioblastoma	go back to main search page
Accession:	RDO:0005677	browse the term
Definition:	A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Synonyms:	exact_synonym:	Giant Cell Glioblastoma; Giant Cell Glioblastomas; Glioblastoma Multiforme; Glioblastomas; Grade IV Astrocytoma; Grade IV Astrocytomas
	primary_id:	MESH:D005909
	alt_id:	OMIM:600259

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Glioblastoma
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	AKT1	v-akt murine thymoma viral oncogene homolog 1			ISS	14	105,235,686	105,262,080	RGD:734543	RGD
G	BECN1	beclin 1, autophagy related		Disease_progression	IEP	17	40,962,150	40,976,310	RGD:6483102	RGD
G	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)			IEP	1	203,148,059	203,155,922	RGD:4892621	RGD
G	CTSB	cathepsin B			IEP	8	11,700,033	11,725,646	RGD:2315515	RGD
G	CTSH	cathepsin H			IEP	15	79,214,092	79,237,420	RGD:1549417	RGD
G	DMBT1	deleted in malignant brain tumors 1			IAGP	10	124,320,181	124,403,252	RGD:1599778	RGD
G	F2	coagulation factor II (thrombin)			IED	11	46,740,743	46,761,056	RGD:1578509	RGD
G	IL16	interleukin 16			ISS	15	81,489,219	81,605,104	RGD:5024941	RGD
G	L1CAM	L1 cell adhesion molecule			IEP	X	153,126,971	153,141,399	RGD:6483067	RGD
G	MAP2K3	mitogen-activated protein kinase kinase 3		Disease_progression	IEP	17	21,187,968	21,218,552	RGD:1641940	RGD
G	MGMT	O-6-methylguanine-DNA methyltransferase			IAGP	10	131,265,454	131,565,783	RGD:2317667	RGD
G	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)		Severity	IEP	16	55,513,081	55,540,586	RGD:7207145	RGD
G	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)		Severity	IEP	11	102,391,239	102,401,478	RGD:7207145	RGD
G	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)		Severity	IEP	20	44,637,547	44,645,200	RGD:7207145	RGD
G	PDPN	podoplanin			IEP	1	13,910,252	13,944,452	RGD:2292241	RGD
G	PECAM1	platelet/endothelial cell adhesion molecule 1			ISS	17	62,396,775	62,404,856	RGD:6771207	RGD
G	PGF	placental growth factor		Disease_progression	IED	14	75,408,533	75,422,467	RGD:6483585	RGD
G	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)			IEA	7	6,012,870	6,048,737	RGD:7240710	OMIM
G	PTEN	phosphatase and tensin homolog			TAS	10	89,623,195	89,728,532	RGD:2290476	RGD
G	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)		Disease_progression	IEP	9	125,132,809	125,157,982	RGD:5688245	RGD
G	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)			ISS	9	125,132,809	125,157,982	RGD:5688250	RGD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)			ISS	1	186,640,944	186,649,559	RGD:5688250	RGD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		Disease_progression	IEP	1	186,640,944	186,649,559	RGD:5688245	RGD
G	TNC	tenascin C			IEP	9	117,781,854	117,880,536	RGD:4889612	RGD

Term paths to the root

Path 1
Term	Annotations
Diseases	29601
Neoplasms	5346
Neoplasms by Histologic Type	1684
Neoplasms, Glandular and Epithelial	1079
Neoplasms, Neuroepithelial	119
Glioma	98
Astrocytoma	34
Glioblastoma	24
Path 2
Term	Annotations
Diseases	29601
Neoplasms	5346
Neoplasms by Histologic Type	1684
Neoplasms, Germ Cell and Embryonal	291
Neuroectodermal Tumors	183
Neoplasms, Neuroepithelial	119
Glioma	98
Astrocytoma	34
Glioblastoma	24