ONTOLOGY REPORT - ANNOTATIONS

Term:Heart Failure
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Accession:RDO:0005421 term browser browse the term
Definition:A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Synonyms:exact_synonym: Cardiac Failure;   Congestive Heart Failure;   Heart Decompensation;   Left Sided Heart Failure;   Myocardial Failure;   Right Sided Heart Failure
 primary_id: MESH:D006333
 alt_id: OMIM:104250;   OMIM:109630

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Heart Failure term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 GBrowse link IPM 10 95,361,338 95,381,455 RGD:2325224 RGD
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 GBrowse link IPM 10 95,361,338 95,381,455 RGD:6893472 RGD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link ISS 11 79,908,291 79,911,065 RGD:5686388 RGD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link ISS 11 79,908,291 79,911,065 RGD:5686806 RGD
G Adm adrenomedullin GBrowse link IED 1 168,380,255 168,382,426 RGD:704370 RGD
G Adra2c adrenoceptor alpha 2C GBrowse link ISS 14 81,107,907 81,109,610 RGD:1300355 RGD
G Adra2c adrenoceptor alpha 2C GBrowse link ISS 14 81,107,907 81,109,610 RGD:7240710 OMIM
G Adrb1 adrenoceptor beta 1 GBrowse link IPM 1 263,025,655 263,027,055 RGD:5129119 RGD
G Adrb1 adrenoceptor beta 1 GBrowse link ISS 1 263,025,655 263,027,055 RGD:737774 RGD
G Adrb1 adrenoceptor beta 1 GBrowse link ISS 1 263,025,655 263,027,055 RGD:7240710 OMIM
G Adrb2 adrenoceptor beta 2, surface GBrowse link IED 18 58,174,958 58,177,000 RGD:5129119 RGD
G Adrb2 adrenoceptor beta 2, surface GBrowse link IEP 18 58,174,958 58,177,000 RGD:4144900 RGD
G Adrb3 adrenoceptor beta 3 GBrowse link ISS 16 69,163,620 69,166,384 RGD:5684398 RGD
G Adrb3 adrenoceptor beta 3 GBrowse link IEP 16 69,163,620 69,166,384 RGD:5684917 RGD
G Adrbk1 adrenergic, beta, receptor kinase 1 GBrowse link ISS 1 206,873,002 206,892,868 RGD:737776 RGD
G Adrbk1 adrenergic, beta, receptor kinase 1 GBrowse link IEP 1 206,873,002 206,892,868 RGD:1625790 RGD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link ISS 19 54,738,556 54,750,349 RGD:1601140 RGD
G Agtr2 angiotensin II receptor, type 2 IEP RGD:6903846 RGD
G Alox12 arachidonate 12-lipoxygenase GBrowse link IEP 10 57,080,603 57,092,874 RGD:5509787 RGD
G Alox15 arachidonate 15-lipoxygenase GBrowse link ISS 10 57,185,939 57,194,388 RGD:5509627 RGD
G Alox15 arachidonate 15-lipoxygenase GBrowse link IEP 10 57,185,939 57,194,388 RGD:1642301 RGD
G Ankrd23 ankyrin repeat domain 23 GBrowse link ISS 9 35,472,715 35,479,314 RGD:2314858 RGD
G Aoc3 amine oxidase, copper containing 3 GBrowse link Severity ISS 10 90,357,094 90,365,040 RGD:2313827 RGD
G Apln apelin GBrowse link ISS X 134,387,285 134,396,762 RGD:1626175 RGD
G Apln apelin GBrowse link IED X 134,387,285 134,396,762 RGD:1626171 RGD
G Apln apelin GBrowse link IEP X 134,387,285 134,396,762 RGD:1626186 RGD
G Apoa1 apolipoprotein A-I ISS RGD:5508219 RGD
G Arrb1 arrestin, beta 1 GBrowse link Disease_progression IPM 1 156,871,564 156,937,540 RGD:5509888 RGD
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 GBrowse link IED 12 35,266,600 35,316,237 RGD:6903963 RGD
G Birc5 baculoviral IAP repeat-containing 5 IEP RGD:2293134 RGD
G Casp1 caspase 1 GBrowse link ISS 8 2,027,976 2,036,872 RGD:2315913 RGD
G Casp12 caspase 12 GBrowse link IEP 8 2,082,933 2,110,511 RGD:2311453 RGD
G Casq2 calsequestrin 2 (cardiac muscle) GBrowse link IEP 2 197,182,938 197,239,201 RGD:6771208 RGD
G Cat catalase GBrowse link ISS 3 88,654,077 88,686,212 RGD:1581151 RGD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link IEP 10 70,256,263 70,258,061 RGD:1581156 RGD
G Ccna2 cyclin A2 GBrowse link ISS 2 123,062,752 123,069,085 RGD:2293348 RGD
G Ccr2 chemokine (C-C motif) receptor 2 GBrowse link ISS 8 128,892,784 128,893,905 RGD:1581177 RGD
G Cd40lg CD40 ligand GBrowse link ISS X 141,925,019 141,937,183 RGD:2314219 RGD
G Chek2 checkpoint kinase 2 GBrowse link ISS 12 45,933,900 45,965,427 RGD:2289708 RGD
G Chi3l1 chitinase 3-like 1 (cartilage glycoprotein-39) GBrowse link ISS 13 47,139,658 47,147,591 RGD:4892629 RGD
G Chrm4 cholinergic receptor, muscarinic 4 GBrowse link IEP 3 76,301,988 76,309,729 RGD:1642301 RGD
G Chrna4 cholinergic receptor, nicotinic, alpha 4 (neuronal) GBrowse link IEP 3 170,171,214 170,185,998 RGD:1642301 RGD
G Corin corin, serine peptidase GBrowse link IEP 14 38,109,932 38,339,631 RGD:1581218 RGD
G Corin corin, serine peptidase GBrowse link IEP 14 38,109,932 38,339,631 RGD:1581217 RGD
G Cst3 cystatin C GBrowse link Susceptibility ISS 3 137,650,903 137,654,776 RGD:2314311 RGD
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 GBrowse link IEP 7 113,043,365 113,049,779 RGD:4891162 RGD
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 GBrowse link IEP 7 13,119,551 13,134,015 RGD:1642301 RGD
G Ddr1 discoidin domain receptor tyrosine kinase 1 GBrowse link IEP 20 3,194,265 3,214,611 RGD:1642301 RGD
G Dio3 deiodinase, iodothyronine, type III IEP RGD:2303417 RGD
G Ece1 endothelin converting enzyme 1 GBrowse link ISS 5 156,635,656 156,735,783 RGD:1580911 RGD
G Edn1 endothelin 1 GBrowse link Severity ISS 17 28,303,886 28,309,775 RGD:4144845 RGD
G Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GBrowse link IEP 10 87,219,157 87,242,919 RGD:1580989 RGD
G Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) GBrowse link IEP 9 66,843,898 67,967,970 RGD:1580989 RGD
G Eya4 eyes absent homolog 4 (Drosophila) GBrowse link ISS 1 22,814,568 22,914,973 RGD:1598455 RGD
G Fkbp1b FK506 binding protein 1b IEP RGD:2302075 RGD
G Fos FBJ osteosarcoma oncogene GBrowse link IEP 6 109,559,135 109,562,001 RGD:2293777 RGD
G Fosl1 fos-like antigen 1 GBrowse link IEP 1 208,090,612 208,099,118 RGD:2293777 RGD
G Foxc2 forkhead box C2 ISS RGD:1582564 RGD
G Foxo1 forkhead box O1 GBrowse link ISS 2 141,127,345 141,203,446 RGD:704404 RGD
G Foxo1 forkhead box O1 GBrowse link ISS 2 141,127,345 141,203,446 RGD:1582564 RGD
G Foxp1 forkhead box P1 GBrowse link ISS 4 133,773,373 134,007,018 RGD:1582564 RGD
G Foxp4 forkhead box P4 GBrowse link ISS 9 8,509,028 8,579,597 RGD:1582564 RGD
G Fth1 ferritin, heavy polypeptide 1 GBrowse link IEP 1 212,430,453 212,432,741 RGD:2315110 RGD
G Grk1 G protein-coupled receptor kinase 1 GBrowse link IED 16 80,979,323 80,991,796 RGD:1600002 RGD
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled GBrowse link IED 15 55,463,743 55,532,293 RGD:1600503 RGD
G Igf1 insulin-like growth factor 1 GBrowse link IEP 7 24,531,669 24,605,742 RGD:1598415 RGD
G Il10 interleukin 10 GBrowse link Disease_progression IEP 13 43,953,900 43,957,766 RGD:1598465 RGD
G Il17a interleukin 17A GBrowse link IPM 9 19,454,979 19,458,467 RGD:4831836 RGD
G Il17a interleukin 17A GBrowse link IEP 9 19,454,979 19,458,467 RGD:2325816 RGD
G Il6 interleukin 6 GBrowse link IEP 4 456,799 461,376 RGD:5128682 RGD
G Il6 interleukin 6 GBrowse link IED 4 456,799 461,376 RGD:2307285 RGD
G Il6r interleukin 6 receptor GBrowse link IEP 2 182,078,049 182,128,135 RGD:1625433 RGD
G Kcne1 potassium voltage-gated channel, Isk-related family, member 1 GBrowse link IEP 11 32,344,529 32,355,189 RGD:1642301 RGD
G Lep leptin GBrowse link ISS 4 55,943,837 55,945,938 RGD:5128823 RGD
G Lepr leptin receptor GBrowse link ISS 5 122,320,075 122,503,449 RGD:5128823 RGD
G Lif leukemia inhibitory factor GBrowse link IEP 14 84,887,856 84,890,630 RGD:2326058 RGD
G Mapk14 mitogen activated protein kinase 14 GBrowse link ISS 20 6,939,249 7,000,378 RGD:1302548 RGD
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) GBrowse link Induced IED 12 22,021,302 22,034,257 RGD:1582470 RGD
G Mmp1 matrix metallopeptidase 1 (interstitial collagenase) GBrowse link ISS 8 4,333,773 4,354,284 RGD:1582539 RGD
G Mmp1 matrix metallopeptidase 1 (interstitial collagenase) GBrowse link IED 8 4,333,773 4,354,284 RGD:7207282 RGD
G Mmp13 matrix metallopeptidase 13 GBrowse link Disease_progression IEP 8 4,158,887 4,169,166 RGD:1582587 RGD
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) GBrowse link Disease_progression IEP 15 32,493,852 32,503,077 RGD:1582587 RGD
G Mmp2 matrix metallopeptidase 2 GBrowse link IEP 19 15,246,036 15,275,061 RGD:2290467 RGD
G Mmp8 matrix metallopeptidase 8 GBrowse link Disease_progression IEP 8 4,402,124 4,410,976 RGD:1582587 RGD
G Mmp9 matrix metallopeptidase 9 GBrowse link ISS 3 155,985,473 155,993,433 RGD:1582647 RGD
G Mmp9 matrix metallopeptidase 9 GBrowse link IEP 3 155,985,473 155,993,433 RGD:5130174 RGD
G Mmp9 matrix metallopeptidase 9 GBrowse link IED 3 155,985,473 155,993,433 RGD:7207137 RGD
G Mstn myostatin GBrowse link IEP 9 45,426,831 45,431,658 RGD:2303554 RGD
G Myh6 myosin, heavy chain 6, cardiac muscle, alpha GBrowse link ISS 15 33,044,506 33,068,098 RGD:1580923 RGD
G Ncam1 neural cell adhesion molecule 1 GBrowse link IEP 8 52,822,350 53,120,572 RGD:2325979 RGD
G Ngfr nerve growth factor receptor GBrowse link IEP 10 84,262,804 84,281,006 RGD:1642301 RGD
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 GBrowse link ISS 10 82,582,766 82,588,269 RGD:5132888 RGD
G Nos1 nitric oxide synthase 1, neuronal GBrowse link IEP 12 39,812,500 39,869,484 RGD:1581144 RGD
G Nppb natriuretic peptide B GBrowse link IAGP 5 165,062,348 165,063,650 RGD:1580139 RGD
G Nppb natriuretic peptide B GBrowse link IAGP 5 165,062,348 165,063,650 RGD:1580140 RGD
G Nppb natriuretic peptide B GBrowse link ISS 5 165,062,348 165,063,650 RGD:1642196 RGD
G Npr1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) GBrowse link ISS 2 182,724,916 182,740,242 RGD:737701 RGD
G Nptxr neuronal pentraxin receptor GBrowse link IEP 7 118,023,653 118,041,729 RGD:1642301 RGD
G Npy neuropeptide Y GBrowse link IEP 4 78,038,013 78,045,187 RGD:7175103 RGD
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 GBrowse link Treatment IPM 18 32,371,496 32,459,145 RGD:7174712 RGD
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 GBrowse link IEP 12 34,943,900 34,961,551 RGD:1642301 RGD
G Pgf placental growth factor GBrowse link IED 6 109,215,540 109,226,122 RGD:6483590 RGD
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma GBrowse link ISS 6 50,441,892 50,476,931 RGD:6482699 RGD
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) GBrowse link ISS 9 13,057,988 13,100,289 RGD:6482778 RGD
G Plcd1 phospholipase C, delta 1 GBrowse link IED 8 124,023,090 124,052,193 RGD:2300431 RGD
G Pld2 phospholipase D2 GBrowse link IEP 10 57,388,474 57,439,063 RGD:2299908 RGD
G Ppargc1a peroxisome proliferator-activated receptor gamma, coactivator 1 alpha GBrowse link Onset ISS 14 64,278,115 64,370,912 RGD:7241838 RGD
G Ppargc1a peroxisome proliferator-activated receptor gamma, coactivator 1 alpha GBrowse link ISS 14 64,278,115 64,370,912 RGD:7241843 RGD
G Ppp1ca protein phosphatase 1, catalytic subunit, alpha isozyme GBrowse link ISS 1 206,774,719 206,778,336 RGD:737728 RGD
G Prkaca protein kinase, cAMP-dependent, catalytic, alpha GBrowse link ISS 19 25,840,795 25,864,786 RGD:1580714 RGD
G Prkar2a protein kinase, cAMP dependent regulatory, type II alpha GBrowse link ISS 8 113,746,384 113,805,476 RGD:1580714 RGD
G Prkca protein kinase C, alpha GBrowse link IEP 10 97,367,196 97,638,910 RGD:2292480 RGD
G Prkcb protein kinase C, beta GBrowse link IEP 1 181,117,512 181,459,856 RGD:1625516 RGD
G Pth parathyroid hormone GBrowse link ISS 1 171,240,596 171,243,528 RGD:7242422 RGD
G Rac1 ras-related C3 botulinum toxin substrate 1 GBrowse link IAGP 12 11,380,314 11,400,531 RGD:1581295 RGD
G Ramp2 receptor (G protein-coupled) activity modifying protein 2 GBrowse link IEP 10 90,275,463 90,277,242 RGD:704370 RGD
G Retn resistin GBrowse link ISS 12 2,499,630 2,501,370 RGD:7207075 RGD
G Rrad Ras-related associated with diabetes GBrowse link ISS 19 272,791 275,957 RGD:2311701 RGD
G Ryr2 ryanodine receptor 2, cardiac GBrowse link Model IED 17 68,959,042 69,544,816 RGD:1599251 RGD
G Scn5a sodium channel, voltage-gated, type V, alpha subunit GBrowse link IEP 8 124,446,479 124,545,301 RGD:6484224 RGD
G Scn8a sodium channel, voltage gated, type VIII, alpha subunit GBrowse link IEP 7 139,686,180 139,794,282 RGD:6484224 RGD
G Selp selectin P GBrowse link IEP 13 79,886,614 79,922,180 RGD:2312309 RGD
G Sirt1 sirtuin 1 GBrowse link ISS 20 25,675,302 25,686,494 RGD:1580423 RGD
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 GBrowse link Severity ISS 10 56,786,705 56,792,209 RGD:2313624 RGD
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GBrowse link ISS 10 67,134,790 67,155,891 RGD:4889438 RGD
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 GBrowse link IEP 6 4,421,046 4,691,716 RGD:1642720 RGD
G Slc9a1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 GBrowse link ISS 5 151,680,696 151,748,460 RGD:6771337 RGD
G Srf serum response factor (c-fos serum response element-binding transcription factor) GBrowse link ISS 9 9,788,378 9,797,639 RGD:1581426 RGD
G Th tyrosine hydroxylase GBrowse link IEP 1 203,164,253 203,171,506 RGD:5128674 RGD
G Th tyrosine hydroxylase GBrowse link ISS 1 203,164,253 203,171,506 RGD:737737 RGD
G Timp1 TIMP metallopeptidase inhibitor 1 GBrowse link IEP X 12,542,496 12,547,094 RGD:2290467 RGD
G Timp2 TIMP metallopeptidase inhibitor 2 GBrowse link IEP 10 108,310,473 108,358,821 RGD:2290467 RGD
G Timp4 tissue inhibitor of metalloproteinase 4 GBrowse link IEP 4 151,375,072 151,381,591 RGD:2290467 RGD
G Tnf tumor necrosis factor GBrowse link IED 20 3,661,000 3,663,618 RGD:1580213 RGD
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b GBrowse link IEP 7 90,606,424 90,634,431 RGD:1624176 RGD
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b GBrowse link ISS 5 163,666,541 163,697,484 RGD:5131262 RGD
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b GBrowse link ISS 5 163,666,541 163,697,484 RGD:5131425 RGD
G Ucn urocortin GBrowse link ISS 6 25,216,788 25,217,618 RGD:5490589 RGD
G Ucn2 urocortin 2 GBrowse link ISS 8 114,003,817 114,005,366 RGD:5508210 RGD
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) GBrowse link IEP 1 157,925,514 157,928,222 RGD:7204424 RGD
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) GBrowse link IEP 1 157,925,514 157,928,222 RGD:7204426 RGD
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) GBrowse link IEP 1 157,896,001 157,909,608 RGD:7204424 RGD
G Uts2 urotensin 2 GBrowse link ISS 5 168,143,315 168,148,700 RGD:1580809 RGD
G Uts2 urotensin 2 GBrowse link Severity ISS 5 168,143,315 168,148,700 RGD:2306804 RGD
S F344-Tg(Cyp1a1-Ren2)10Jmul IAGP RGD:2313695 RGD
S LEW.F344-(D10Rat99-D10Rat11)/Jmul GBrowse link IAGP 10 89,278,229 100,633,982 RGD:2313695 RGD
S SHHF/Bbb Model IED RGD:2293766 RGD
Dyspnea, Paroxysmal term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adora1 adenosine A1 receptor GBrowse link ISS 13 47,160,292 47,192,804 RGD:5129099 RGD
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  Diseases 30477
    Cardiovascular Diseases 5260
      Heart Diseases 1977
        Heart Failure 148
          Cardio-Renal Syndrome 0
          Dyspnea, Paroxysmal 1
          Edema, Cardiac 0
          Heart Failure, Diastolic 0
          Heart Failure, Systolic 0
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