ONTOLOGY REPORT - ANNOTATIONS
Term: Diabetic Nephropathies
Accession: RDO:0005355
browse the term
Definition: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Synonyms: exact_synonym: Diabetic Glomerulosclerosis; Diabetic Kidney Disease; Diabetic Kidney Diseases; Diabetic Nephropathy; Intracapillary Glomerulosclerosis; Kimmelstiel Wilson Disease; Kimmelstiel Wilson Syndrome; Nodular Glomerulosclerosis
primary_id: MESH:D003928
alt_id: OMIM:106180
Diabetic Nephropathies
G
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
IEA
10
95,361,338
95,381,455
RGD:1331525
RGD
G
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
IPM
10
95,361,338
95,381,455
RGD:2311449
RGD
G
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
ISS
10
95,361,338
95,381,455
RGD:7240710
OMIM
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
ISS
X
51,051,758
51,096,036
RGD:2313796
RGD
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
No_Association
ISS
X
51,051,758
51,096,036
RGD:2313800
RGD
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
ISS
X
51,051,758
51,096,036
RGD:2313800
RGD
G
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
ISS
X
51,051,758
51,096,036
RGD:2313797
RGD
G
Acvr1
activin A receptor, type I
IEP
3
40,191,727
40,260,488
RGD:2313802
RGD
G
Adipoq
adiponectin, C1Q and collagen domain containing
ISS
11
79,908,291
79,911,065
RGD:5686409
RGD
G
Adora1
adenosine A1 receptor
IPM
13
47,160,292
47,192,804
RGD:2313803
RGD
G
Adra2b
adrenoceptor alpha 2B
ISS
3
114,867,357
114,869,680
RGD:2313545
RGD
G
Adrb3
adrenoceptor beta 3
ISS
16
69,163,620
69,166,384
RGD:5684403
RGD
G
Ager
advanced glycosylation end product-specific receptor
IEP
20
4,250,613
4,253,540
RGD:2325651
RGD
G
Ager
advanced glycosylation end product-specific receptor
Treatment
IED
20
4,250,613
4,253,540
RGD:7243852
RGD
G
Ager
advanced glycosylation end product-specific receptor
Treatment
ISS
20
4,250,613
4,253,540
RGD:7243248
RGD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
IEA
19
54,738,556
54,750,349
RGD:1331525
RGD
G
Agtr1a
angiotensin II receptor, type 1a
IPM
17
40,629,318
40,684,982
RGD:6903861
RGD
G
Agtr2
angiotensin II receptor, type 2
IEP
RGD:6903847
RGD
G
Ahsg
alpha-2-HS-glycoprotein
ISS
11
80,330,615
80,336,658
RGD:2313813
RGD
G
Akr1b1
aldo-keto reductase family 1, member B1 (aldose reductase)
ISS
4
61,645,438
61,659,530
RGD:734542
RGD
G
Alb
albumin
IEP
14
19,126,935
19,142,214
RGD:2306882
RGD
G
Alb
albumin
IEP
14
19,126,935
19,142,214
RGD:2306885
RGD
G
Alb
albumin
ISS
14
19,126,935
19,142,214
RGD:2306886
RGD
G
Alb
albumin
IEP
14
19,126,935
19,142,214
RGD:5135032
RGD
G
Apoa1
apolipoprotein A-I
ISS
RGD:2313960
RGD
G
Apoa2
apolipoprotein A-II
ISS
13
87,114,734
87,116,372
RGD:2313958
RGD
G
Apoa2
apolipoprotein A-II
ISS
13
87,114,734
87,116,372
RGD:2313960
RGD
G
Apob
apolipoprotein B
ISS
6
31,508,060
31,548,083
RGD:2313979
RGD
G
Apoc1
apolipoprotein C-I
ISS
1
78,996,677
78,999,960
RGD:2313950
RGD
G
Apoc3
apolipoprotein C-III
ISS
RGD:2306755
RGD
G
Apoe
apolipoprotein E
ISS
1
79,003,634
79,006,387
RGD:6902935
RGD
G
Apoe
apolipoprotein E
Susceptibility
ISS
1
79,003,634
79,006,387
RGD:6903840
RGD
G
Apoh
apolipoprotein H (beta-2-glycoprotein I)
ISS
10
97,725,088
97,739,213
RGD:2313989
RGD
G
Aqp2
aquaporin 2 (collecting duct)
ISS
7
138,325,855
138,330,891
RGD:2314343
RGD
G
Arg2
arginase type II
ISS
6
101,901,653
101,928,282
RGD:6902923
RGD
G
Axl
Axl receptor tyrosine kinase
ISS
1
80,964,751
80,994,300
RGD:1579938
RGD
G
Bdkrb1
bradykinin receptor B1
ISS
6
129,760,129
129,762,545
RGD:7241550
RGD
G
Bdkrb2
bradykinin receptor B2
Susceptibility
ISS
6
129,744,781
129,748,851
RGD:2313335
RGD
G
Bdnf
brain-derived neurotrophic factor
IPM
RGD:4891134
RGD
G
Becn1
beclin 1, autophagy related
IEP
10
90,317,957
90,333,329
RGD:6483069
RGD
G
Bglap
bone gamma-carboxyglutamate (gla) protein
ISS
2
180,482,313
180,483,290
RGD:7207424
RGD
G
Bmp7
bone morphogenetic protein 7
IEP
3
163,723,429
163,799,567
RGD:2289036
RGD
G
C3
complement component 3
ISS
RGD:7183082
RGD
G
Casp12
caspase 12
IEP
8
2,082,933
2,110,511
RGD:2311449
RGD
G
Casp3
caspase 3
IEP
16
48,944,226
48,962,420
RGD:2311440
RGD
G
Cat
catalase
IEP
3
88,654,077
88,686,212
RGD:7205662
RGD
G
Cat
catalase
IPM
3
88,654,077
88,686,212
RGD:7205676
RGD
G
Cat
catalase
IED
3
88,654,077
88,686,212
RGD:7205665
RGD
G
Cat
catalase
ISS
3
88,654,077
88,686,212
RGD:7205651
RGD
G
Ccl2
chemokine (C-C motif) ligand 2
Disease_progression
ISS
10
70,256,263
70,258,061
RGD:2306982
RGD
G
Ccl2
chemokine (C-C motif) ligand 2
IEP
10
70,256,263
70,258,061
RGD:2306980
RGD
G
Ccl2
chemokine (C-C motif) ligand 2
Susceptibility
ISS
10
70,256,263
70,258,061
RGD:2306991
RGD
G
Ccl2
chemokine (C-C motif) ligand 2
IEP
10
70,256,263
70,258,061
RGD:2306989
RGD
G
Ccl2
chemokine (C-C motif) ligand 2
Disease_progression
ISS
10
70,256,263
70,258,061
RGD:2306979
RGD
G
Ccl5
chemokine (C-C motif) ligand 5
Susceptibility
ISS
10
71,605,791
71,610,330
RGD:2307107
RGD
G
Ccl5
chemokine (C-C motif) ligand 5
ISS
10
71,605,791
71,610,330
RGD:2307063
RGD
G
Ccne1
cyclin E1
IEP
1
90,568,189
90,577,426
RGD:2289273
RGD
G
Ccr2
chemokine (C-C motif) receptor 2
ISS
8
128,892,784
128,893,905
RGD:2313558
RGD
G
Ccr2
chemokine (C-C motif) receptor 2
No_Association
ISS
8
128,892,784
128,893,905
RGD:2313563
RGD
G
Ccr5
chemokine (C-C motif) receptor 5
Susceptibility
ISS
8
128,907,157
128,912,272
RGD:2307107
RGD
G
Cd36
CD36 molecule (thrombospondin receptor)
IEP
4
13,471,878
13,525,620
RGD:2307215
RGD
G
Cd38
CD38 molecule
IPM
14
72,320,479
72,360,329
RGD:2307227
RGD
G
Cd38
CD38 molecule
ISS
14
72,320,479
72,360,329
RGD:2307228
RGD
G
Cd40lg
CD40 ligand
ISS
X
141,925,019
141,937,183
RGD:2314208
RGD
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
IEP
4
171,841,705
171,846,506
RGD:2293628
RGD
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
IEP
4
171,841,705
171,846,506
RGD:2293619
RGD
G
Cndp1
carnosine dipeptidase 1 (metallopeptidase M20 family)
ISS
18
81,160,681
81,183,558
RGD:7207213
RGD
G
Col4a1
collagen, type IV, alpha 1
ISS
16
83,045,183
83,157,835
RGD:2311340
RGD
G
Col4a1
collagen, type IV, alpha 1
ISS
16
83,045,183
83,157,835
RGD:2311342
RGD
G
Cpb2
carboxypeptidase B2 (plasma)
Susceptibility
ISS
15
56,104,920
56,154,321
RGD:7243116
RGD
G
Cpb2
carboxypeptidase B2 (plasma)
ISS
15
56,104,920
56,154,321
RGD:7243123
RGD
G
Crp
C-reactive protein, pentraxin-related
Disease_progression
ISS
13
88,702,243
88,703,153
RGD:6906965
RGD
G
Crp
C-reactive protein, pentraxin-related
ISS
13
88,702,243
88,703,153
RGD:6906967
RGD
G
Cst3
cystatin C
IEP
3
137,650,903
137,654,776
RGD:2314297
RGD
G
Cst3
cystatin C
ISS
3
137,650,903
137,654,776
RGD:2314328
RGD
G
Ctgf
connective tissue growth factor
IEP
1
21,327,099
21,330,215
RGD:2314366
RGD
G
Ctgf
connective tissue growth factor
IEP
1
21,327,099
21,330,215
RGD:2314604
RGD
G
Ctla4
cytotoxic T-lymphocyte-associated protein 4
ISS
9
59,495,773
59,501,300
RGD:2312302
RGD
G
Cubn
cubilin (intrinsic factor-cobalamin receptor)
IEP
17
87,545,893
87,772,079
RGD:1599655
RGD
G
Cxcl10
chemokine (C-X-C motif) ligand 10
ISS
14
17,265,986
17,268,183
RGD:2311359
RGD
G
Cxcl10
chemokine (C-X-C motif) ligand 10
ISS
14
17,265,986
17,268,183
RGD:2311357
RGD
G
Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
Susceptibility
ISS
7
113,043,365
113,049,779
RGD:2307295
RGD
G
Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
ISS
5
116,702,370
116,729,722
RGD:7243153
RGD
G
Dcn
decorin
ISS
7
35,004,234
35,045,191
RGD:2311415
RGD
G
Dcn
decorin
ISS
7
35,004,234
35,045,191
RGD:2311412
RGD
G
Dcn
decorin
ISS
7
35,004,234
35,045,191
RGD:2311411
RGD
G
Dcn
decorin
ISS
7
35,004,234
35,045,191
RGD:2311416
RGD
G
Dkk1
dickkopf 1 homolog (Xenopus laevis)
IPM
1
234,392,743
234,396,426
RGD:6907383
RGD
G
Edn1
endothelin 1
ISS
17
28,303,886
28,309,775
RGD:2313284
RGD
G
Ednra
endothelin receptor type A
IPM
19
32,042,366
32,108,153
RGD:4892326
RGD
G
Egf
epidermal growth factor
ISS
2
227,103,900
227,195,062
RGD:6906912
RGD
G
Eng
endoglin
ISS
RGD:2313795
RGD
G
Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
ISS
1
21,223,678
21,287,411
RGD:6906926
RGD
G
Ephx2
epoxide hydrolase 2, cytoplasmic
ISS
15
45,497,660
45,556,101
RGD:5688728
RGD
G
Epo
erythropoietin
ISS
12
19,551,768
19,555,208
RGD:2313832
RGD
G
Epo
erythropoietin
ISS
12
19,551,768
19,555,208
RGD:2313838
RGD
G
Epo
erythropoietin
ISS
12
19,551,768
19,555,208
RGD:2313833
RGD
G
Esr1
estrogen receptor 1
IEP
1
35,523,680
35,759,891
RGD:2314020
RGD
G
Esr1
estrogen receptor 1
ISS
1
35,523,680
35,759,891
RGD:2314005
RGD
G
F2
coagulation factor II
Disease_progression
ISS
3
76,005,318
76,018,603
RGD:6893574
RGD
G
F2
coagulation factor II
ISS
3
76,005,318
76,018,603
RGD:6893575
RGD
G
F3
coagulation factor III (thromboplastin, tissue factor)
ISS
2
218,371,050
218,382,645
RGD:2313863
RGD
G
Fabp2
fatty acid binding protein 2, intestinal
ISS
2
219,591,502
219,605,097
RGD:1578457
RGD
G
Fas
Fas (TNF receptor superfamily, member 6)
ISS
1
238,259,443
238,274,745
RGD:2312739
RGD
G
Fas
Fas (TNF receptor superfamily, member 6)
ISS
1
238,259,443
238,274,745
RGD:2315705
RGD
G
Faslg
Fas ligand (TNF superfamily, member 6)
ISS
13
77,472,950
77,480,210
RGD:2315705
RGD
G
Fgf2
fibroblast growth factor 2
ISS
2
123,893,314
123,947,136
RGD:2315842
RGD
G
Flt1
FMS-related tyrosine kinase 1
ISS
12
7,858,092
8,035,966
RGD:2313731
RGD
G
Fmod
fibromodulin
ISS
13
46,987,714
46,998,331
RGD:2311416
RGD
G
Fmod
fibromodulin
ISS
13
46,987,714
46,998,331
RGD:2311412
RGD
G
Fn1
fibronectin 1
ISS
9
70,702,181
70,771,155
RGD:7206843
RGD
G
Fuca1
fucosidase, alpha-L- 1, tissue
ISS
5
154,703,722
154,720,971
RGD:2315943
RGD
G
Gas6
growth arrest specific 6
ISS
16
80,900,159
80,930,929
RGD:1579938
RGD
G
Gfpt1
glutamine fructose-6-phosphate transaminase 1
ISS
4
121,204,274
121,250,160
RGD:2313353
RGD
G
Gfpt2
glutamine-fructose-6-phosphate transaminase 2
Susceptibility
ISS
10
35,290,139
35,336,286
RGD:2307362
RGD
G
Ghr
growth hormone receptor
ISS
2
52,496,517
52,658,066
RGD:2307370
RGD
G
Ghr
growth hormone receptor
Susceptibility
ISS
2
52,496,517
52,658,066
RGD:2307369
RGD
G
Ghr
growth hormone receptor
IEP
2
52,496,517
52,658,066
RGD:2307368
RGD
G
Ghr
growth hormone receptor
IPM
2
52,496,517
52,658,066
RGD:2307364
RGD
G
Gipr
gastric inhibitory polypeptide receptor
ISS
1
78,515,051
78,526,160
RGD:2306734
RGD
G
Glo1
glyoxalase 1
No_Association
ISS
20
8,900,984
8,919,001
RGD:7242569
RGD
G
Gpx1
glutathione peroxidase 1
ISS
RGD:2306609
RGD
G
Gpx3
glutathione peroxidase 3
ISS
10
40,311,094
40,319,382
RGD:2312635
RGD
G
Hgf
hepatocyte growth factor
ISS
4
14,864,357
14,932,513
RGD:2313567
RGD
G
Hnf4a
hepatocyte nuclear factor 4, alpha
IEP
3
154,459,863
154,482,825
RGD:2301838
RGD
G
Hspa1b
heat shock protein 1B
ISS
20
3,955,274
3,957,748
RGD:7242747
RGD
G
Hspa8
heat shock 70kDa protein 8
ISS
8
43,784,035
43,787,760
RGD:7242762
RGD
G
Icam1
intercellular adhesion molecule 1
ISS
8
20,040,177
20,051,939
RGD:4145414
RGD
G
Icam1
intercellular adhesion molecule 1
IED
8
20,040,177
20,051,939
RGD:2313470
RGD
G
Icam1
intercellular adhesion molecule 1
ISS
8
20,040,177
20,051,939
RGD:2312766
RGD
G
Icam1
intercellular adhesion molecule 1
ISS
8
20,040,177
20,051,939
RGD:2313475
RGD
G
Ifng
interferon gamma
ISS
7
57,621,756
57,625,792
RGD:6893364
RGD
G
Igf1
insulin-like growth factor 1
ISS
7
24,531,669
24,605,742
RGD:2313764
RGD
G
Igf2
insulin-like growth factor 2
IEP
1
202,906,624
202,915,231
RGD:5510022
RGD
G
Igf2
insulin-like growth factor 2
ISS
1
202,906,624
202,915,231
RGD:5510019
RGD
G
Igf2
insulin-like growth factor 2
IEP
1
202,906,624
202,915,231
RGD:5510019
RGD
G
Igfbp1
insulin-like growth factor binding protein 1
ISS
14
87,950,222
87,955,289
RGD:1625238
RGD
G
Il10
interleukin 10
Susceptibility
ISS
13
43,953,900
43,957,766
RGD:2308943
RGD
G
Il1b
interleukin 1 beta
ISS
3
116,964,422
116,970,867
RGD:7175266
RGD
G
Il1b
interleukin 1 beta
IED
3
116,964,422
116,970,867
RGD:7175519
RGD
G
Il1rn
interleukin 1 receptor antagonist
No_Association
ISS
3
2,607,800
2,613,216
RGD:6909120
RGD
G
Il1rn
interleukin 1 receptor antagonist
ISS
3
2,607,800
2,613,216
RGD:6907371
RGD
G
Il6
interleukin 6
IED
4
456,799
461,376
RGD:2307281
RGD
G
Il6
interleukin 6
ISS
4
456,799
461,376
RGD:2307282
RGD
G
Ins2
insulin 2
Resistance
IED
1
202,935,548
202,936,379
RGD:6902908
RGD
G
Itga2
integrin, alpha 2
Severity
ISS
2
46,967,681
47,080,909
RGD:2307420
RGD
G
Keap1
Kelch-like ECH-associated protein 1
IED
8
20,259,178
20,266,351
RGD:6893386
RGD
G
Klk1c12
kallikrein 1-related peptidase C12
ISS
1
94,355,758
94,359,795
RGD:1641794
RGD
G
Kng1
kininogen 1
ISS
11
80,109,499
80,131,887
RGD:2311541
RGD
G
Lamb2
laminin, beta 2
IEP
RGD:7207449
RGD
G
Lep
leptin
ISS
4
55,943,837
55,945,938
RGD:6907074
RGD
G
Lmna
lamin A/C
ISS
2
180,595,724
180,616,354
RGD:2306095
RGD
G
Lnpep
leucyl/cystinyl aminopeptidase
ISS
1
56,063,361
56,151,257
RGD:2311543
RGD
G
Lpl
lipoprotein lipase
Resistance
ISS
16
22,533,105
22,556,905
RGD:2306755
RGD
G
Lta
lymphotoxin alpha (TNF superfamily, member 1)
ISS
20
3,657,842
3,659,848
RGD:2313255
RGD
G
Mapk14
mitogen activated protein kinase 14
ISS
20
6,939,249
7,000,378
RGD:2311566
RGD
G
Mmp12
matrix metallopeptidase 12
ISS
8
4,249,938
4,259,675
RGD:7241216
RGD
G
Mmp3
matrix metallopeptidase 3
ISS
8
4,315,601
4,329,146
RGD:7241249
RGD
G
Mthfr
methylenetetrahydrofolate reductase (NAD(P)H)
No_Association
ISS
5
165,112,850
165,126,885
RGD:6893576
RGD
G
Mthfr
methylenetetrahydrofolate reductase (NAD(P)H)
Susceptibility
ISS
5
165,112,850
165,126,885
RGD:6893524
RGD
G
Nat2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
ISS
16
23,855,555
23,876,531
RGD:2311598
RGD
G
Nfe2l2
nuclear factor, erythroid derived 2, like 2
IED
3
58,366,693
58,394,116
RGD:6893386
RGD
G
Nox4
NADPH oxidase 4
IEP
1
143,415,816
143,603,554
RGD:2324670
RGD
G
Nox4
NADPH oxidase 4
IPM
1
143,415,816
143,603,554
RGD:2324673
RGD
G
Nppa
natriuretic peptide A
No_Association
ISS
5
165,074,518
165,075,827
RGD:2313593
RGD
G
Nppa
natriuretic peptide A
IEP
5
165,074,518
165,075,827
RGD:2313592
RGD
G
Nppa
natriuretic peptide A
Disease_progression
ISS
5
165,074,518
165,075,827
RGD:2313590
RGD
G
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
IPM
17
11,494,463
11,811,654
RGD:4891134
RGD
G
Pax2
paired box 2
IEP
1
249,804,055
249,895,306
RGD:2316747
RGD
G
Pdgfa
platelet-derived growth factor alpha polypeptide
ISS
12
16,151,045
16,172,412
RGD:2311649
RGD
G
Pdgfb
platelet-derived growth factor beta polypeptide
ISS
7
118,244,385
118,262,021
RGD:2311646
RGD
G
Pdgfrb
platelet derived growth factor receptor, beta polypeptide
ISS
18
57,014,475
57,053,581
RGD:2311646
RGD
G
Pecam1
platelet/endothelial cell adhesion molecule 1
ISS
10
96,056,220
96,057,232
RGD:2311655
RGD
G
Pgf
placental growth factor
Disease_progression
ISS
6
109,215,540
109,226,122
RGD:6483606
RGD
G
Plat
plasminogen activator, tissue
ISS
16
73,711,323
73,736,328
RGD:2311671
RGD
G
Plau
plasminogen activator, urokinase
IEP
15
3,680,072
3,686,232
RGD:1580123
RGD
G
Pon1
paraoxonase 1
ISS
4
29,936,314
29,964,821
RGD:2313272
RGD
G
Pon1
paraoxonase 1
ISS
4
29,936,314
29,964,821
RGD:2313266
RGD
G
Pon2
paraoxonase 2
ISS
4
30,033,229
30,068,643
RGD:2313492
RGD
G
Pparg
peroxisome proliferator-activated receptor gamma
IPM
4
151,492,220
151,617,331
RGD:2301862
RGD
G
Pparg
peroxisome proliferator-activated receptor gamma
ISS
4
151,492,220
151,617,331
RGD:2301845
RGD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
ISS
14
64,278,115
64,370,912
RGD:7242045
RGD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
ISS
14
64,278,115
64,370,912
RGD:7242027
RGD
G
Prkcb
protein kinase C, beta
IED
1
181,117,512
181,459,856
RGD:729635
RGD
G
Prss1
protease, serine, 1 (trypsin 1)
ISS
4
69,185,877
69,189,080
RGD:2324899
RGD
G
Prss2
protease, serine, 2
ISS
4
69,088,288
69,093,312
RGD:2324899
RGD
G
Pten
phosphatase and tensin homolog
IEP
1
236,771,027
236,837,261
RGD:2292546
RGD
G
Ptgds
prostaglandin D2 synthase (brain)
Susceptibility
ISS
3
3,632,683
3,635,617
RGD:1642581
RGD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IPM
13
64,427,288
64,432,978
RGD:5688268
RGD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IPM
13
64,427,288
64,432,978
RGD:5135032
RGD
G
Pth
parathyroid hormone
ISS
1
171,240,596
171,243,528
RGD:7242744
RGD
G
Ren
renin
IED
13
46,262,936
46,275,213
RGD:1579795
RGD
G
Retn
resistin
ISS
12
2,499,630
2,501,370
RGD:7207159
RGD
G
Selp
selectin P
Severity
ISS
13
79,886,614
79,922,180
RGD:2312302
RGD
G
Selp
selectin P
IEP
13
79,886,614
79,922,180
RGD:2312294
RGD
G
Serpinb7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
ISS
13
13,464,818
13,506,372
RGD:7207378
RGD
G
Serpinb7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
ISS
13
13,464,818
13,506,372
RGD:7207374
RGD
G
Serpine1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
IEP
12
20,931,996
20,942,374
RGD:1580123
RGD
G
Serpinf1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
IED
10
62,713,441
62,739,444
RGD:1359799
RGD
G
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
ISS
5
139,690,801
139,719,021
RGD:2312305
RGD
G
Smad6
SMAD family member 6
IEP
8
68,144,395
68,214,652
RGD:2289036
RGD
G
Sod1
superoxide dismutase 1, soluble
ISS
11
29,810,766
29,816,342
RGD:2312365
RGD
G
Sod1
superoxide dismutase 1, soluble
ISS
11
29,810,766
29,816,342
RGD:2312361
RGD
G
Sod2
superoxide dismutase 2, mitochondrial
ISS
1
41,862,997
41,870,327
RGD:7175540
RGD
G
Sod3
superoxide dismutase 3, extracellular
ISS
14
63,381,447
63,387,180
RGD:2312361
RGD
G
Sparc
secreted protein, acidic, cysteine-rich (osteonectin)
IEP
10
40,809,730
40,831,481
RGD:2300072
RGD
G
Spp1
secreted phosphoprotein 1
IED
RGD:1581328
RGD
G
Srebf1
sterol regulatory element binding transcription factor 1
ISS
10
46,461,684
46,483,646
RGD:2308815
RGD
G
Srebf1
sterol regulatory element binding transcription factor 1
IEP
10
46,461,684
46,483,646
RGD:2308806
RGD
G
Srebf1
sterol regulatory element binding transcription factor 1
ISS
10
46,461,684
46,483,646
RGD:2308811
RGD
G
Srebf1
sterol regulatory element binding transcription factor 1
ISS
10
46,461,684
46,483,646
RGD:1581418
RGD
G
Srebf1
sterol regulatory element binding transcription factor 1
ISS
10
46,461,684
46,483,646
RGD:2308811
RGD
G
Srebf2
sterol regulatory element binding transcription factor 2
ISS
7
120,522,511
120,580,212
RGD:1581418
RGD
G
Srebf2
sterol regulatory element binding transcription factor 2
ISS
7
120,522,511
120,580,212
RGD:2308815
RGD
G
Tcf7l2
transcription factor 7-like 2 (T-cell specific, HMG-box)
ISS
1
262,031,823
262,226,710
RGD:6906926
RGD
G
Tgfb1
transforming growth factor, beta 1
ISS
1
80,894,705
80,911,020
RGD:2306734
RGD
G
Tgfbi
transforming growth factor, beta induced
IEP
17
13,904,882
13,935,110
RGD:1304421
RGD
G
Tgif1
TGFB-induced factor homeobox 1
IEP
9
110,043,164
110,052,783
RGD:1599409
RGD
G
Thbs1
thrombospondin 1
ISS
RGD:2317941
RGD
G
Timp2
TIMP metallopeptidase inhibitor 2
IEP
10
108,310,473
108,358,821
RGD:2290407
RGD
G
Tlr2
toll-like receptor 2
ISS
2
175,607,990
175,613,992
RGD:7241083
RGD
G
Tlr4
toll-like receptor 4
ISS
5
83,564,100
83,577,735
RGD:7207902
RGD
G
Tnf
tumor necrosis factor
IED
20
3,661,000
3,663,618
RGD:1580208
RGD
G
Tnf
tumor necrosis factor
ISS
20
3,661,000
3,663,618
RGD:1580311
RGD
G
Tnf
tumor necrosis factor
IEP
20
3,661,000
3,663,618
RGD:5135032
RGD
G
Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b
Disease_progression
ISS
7
90,606,424
90,634,431
RGD:7205493
RGD
G
Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b
Treatment
ISS
7
90,606,424
90,634,431
RGD:7205514
RGD
G
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
ISS
2
113,204,303
113,221,550
RGD:2312739
RGD
G
Tp53
tumor protein p53
IEP
10
56,399,721
56,411,150
RGD:2290561
RGD
G
Trpc1
transient receptor potential cation channel, subfamily C, member 1
IEP
8
100,770,833
100,821,420
RGD:2301838
RGD
G
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
Treatment
ISS
1
157,925,514
157,928,222
RGD:7175295
RGD
G
Uts2
urotensin 2
IEP
5
168,143,315
168,148,700
RGD:2306786
RGD
G
Uts2
urotensin 2
ISS
5
168,143,315
168,148,700
RGD:2306805
RGD
G
Uts2
urotensin 2
Disease_progression
ISS
5
168,143,315
168,148,700
RGD:2306806
RGD
G
Uts2r
urotensin 2 receptor
ISS
10
110,394,782
110,395,942
RGD:2306805
RGD
G
Uts2r
urotensin 2 receptor
IEP
10
110,394,782
110,395,942
RGD:2306786
RGD
G
Vcam1
vascular cell adhesion molecule 1
ISS
2
212,277,654
212,297,376
RGD:7241237
RGD
G
Vcam1
vascular cell adhesion molecule 1
IEP
2
212,277,654
212,297,376
RGD:7240523
RGD
G
Vegfa
vascular endothelial growth factor A
ISS
9
10,520,730
10,536,071
RGD:2313731
RGD
G
Xylt1
xylosyltransferase 1
ISS
1
175,673,299
175,802,134
RGD:2313138
RGD
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 4
G
Il1rn
interleukin 1 receptor antagonist
ISS
3
2,607,800
2,613,216
RGD:7240710
OMIM
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5
G
Pon1
paraoxonase 1
ISS
4
29,936,314
29,964,821
RGD:7240710
OMIM
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6
G
Sod2
superoxide dismutase 2, mitochondrial
ISS
1
41,862,997
41,870,327
RGD:7240710
OMIM
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest
Path 1
Diseases
30477
Male Urogenital Diseases
3832
Urologic Diseases
2439
Kidney Diseases
1871
Diabetic Nephropathies
241
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 1
0
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 4
1
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5
1
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6
1
Path 2
Diseases
30477
Nutritional and Metabolic Diseases
5272
Metabolic Diseases
4653
Glucose Metabolism Disorders
2805
Diabetes Mellitus
2080
Diabetes Complications
427
Diabetic Nephropathies
241
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 1
0
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 4
1
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5
1
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6
1