ONTOLOGY REPORT - ANNOTATIONS

Term:Osteoarthritis
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Accession:RDO:0001314 term browser browse the term
Definition:A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Synonyms:exact_synonym: DIPOA;   Degenerative Arthritides;   Degenerative Arthritis;   GOA1;   HAND OSTEOARTHRITIS;   HOA HEBERDEN NODES;   OA;   OADIP;   OS1;   OS2;   OS3;   OS4;   OS5;   OS6;   OSTEOARTHRITIS OF DISTAL INTERPHALANGEAL JOINTS;   OSTEOARTHRITIS OF HIP;   OSTEOARTHRITIS OF HIP, FEMALE-SPECIFIC, SUSCEPTIBILITY TO;   OSTEOARTHRITIS OF KNEE;   OSTEOARTHRITIS OF KNEE/HIP;   OSTEOARTHRITIS SUSCEPTIBILITY 1;   OSTEOARTHRITIS SUSCEPTIBILITY 2;   OSTEOARTHRITIS SUSCEPTIBILITY 3;   OSTEOARTHRITIS SUSCEPTIBILITY 4;   OSTEOARTHRITIS SUSCEPTIBILITY 5;   OSTEOARTHRITIS SUSCEPTIBILITY 6;   OSTEOARTHRITIS, GENERALIZED, WITHOUT DYSPLASIA;   Osteoarthritides;   Osteoarthroses;   Osteoarthrosis;   Osteoarthrosis Deformans
 primary_id: MESH:D010003
 alt_id: OMIM:120140;   OMIM:140600;   OMIM:165720;   OMIM:607850;   OMIM:610839;   OMIM:612400;   OMIM:612401

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Osteoarthritis term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adam12 ADAM metallopeptidase domain 12 GBrowse link Susceptibility ISS 1 193,384,457 193,650,892 RGD:1625347 RGD
G Adam15 ADAM metallopeptidase domain 15 GBrowse link ISS 2 181,527,175 181,537,640 RGD:1559176 RGD
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 GBrowse link ISS 20 28,555,684 28,631,824 RGD:6771189 RGD
G Aspn asporin GBrowse link ISS 17 21,035,597 21,058,999 RGD:7240710 OMIM
G Becn1 beclin 1, autophagy related GBrowse link ISS 10 90,317,957 90,333,329 RGD:6483317 RGD
G Becn1 beclin 1, autophagy related GBrowse link ISS 10 90,317,957 90,333,329 RGD:6483317 RGD
G Bglap bone gamma-carboxyglutamate (gla) protein GBrowse link Disease_progression ISS 2 180,482,313 180,483,290 RGD:6483599 RGD
G Bmp2 bone morphogenetic protein 2 GBrowse link Susceptibility ISS 3 121,372,692 121,381,236 RGD:1625347 RGD
G Cd36 CD36 molecule (thrombospondin receptor) GBrowse link Susceptibility ISS 4 13,471,878 13,525,620 RGD:1625347 RGD
G Cilp cartilage intermediate layer protein, nucleotide pyrophosphohydrolase GBrowse link Disease_progression ISS 8 69,501,820 69,517,136 RGD:1625347 RGD
G Clec3b C-type lectin domain family 3, member B Disease_progression ISS RGD:1625347 RGD
G Col1a1 collagen, type I, alpha 1 GBrowse link No_Association ISS 10 83,622,438 83,639,368 RGD:5688331 RGD
G Col2a1 collagen, type II, alpha 1 GBrowse link ISS 7 136,679,219 136,707,976 RGD:7240710 OMIM
G Ctsk cathepsin K GBrowse link ISS 2 190,394,854 190,405,668 RGD:734856 RGD
G Egr1 early growth response 1 GBrowse link ISS 18 27,343,919 27,346,117 RGD:1626498 RGD
G Fcgr2a Fc fragment of IgG, low affinity IIa, receptor GBrowse link ISS 13 86,898,651 86,911,743 RGD:5147984 RGD
G Frzb frizzled-related protein GBrowse link ISS 3 63,350,504 63,383,436 RGD:7240710 OMIM
G Gdf5 growth differentiation factor 5 ISS RGD:7240710 OMIM
G Il5 interleukin 5 GBrowse link ISS 10 39,177,786 39,180,657 RGD:5687147 RGD
G Jag1 jagged 1 GBrowse link ISS 3 125,181,063 125,216,481 RGD:6482239 RGD
G Matn3 matrilin 3 GBrowse link ISS 6 32,439,372 32,459,031 RGD:7240710 OMIM
G Mmp1 matrix metallopeptidase 1 (interstitial collagenase) GBrowse link ISS 8 4,333,773 4,354,284 RGD:7207129 RGD
G Mmp13 matrix metallopeptidase 13 GBrowse link ISS 8 4,158,887 4,169,166 RGD:7207089 RGD
G Mmp2 matrix metallopeptidase 2 GBrowse link ISS 19 15,246,036 15,275,061 RGD:7207131 RGD
G Mmp3 matrix metallopeptidase 3 GBrowse link ISS 8 4,315,601 4,329,146 RGD:7207089 RGD
G Mmp3 matrix metallopeptidase 3 GBrowse link ISS 8 4,315,601 4,329,146 RGD:7207131 RGD
G Mmp8 matrix metallopeptidase 8 GBrowse link ISS 8 4,402,124 4,410,976 RGD:7207131 RGD
G Mmp9 matrix metallopeptidase 9 GBrowse link ISS 3 155,985,473 155,993,433 RGD:7207131 RGD
G Ncor2 nuclear receptor co-repressor 2 GBrowse link Susceptibility ISS 12 32,617,643 32,725,753 RGD:1625347 RGD
G Pecam1 platelet/endothelial cell adhesion molecule 1 GBrowse link IEP 10 96,056,220 96,057,232 RGD:6771362 RGD
G Pomc proopiomelanocortin GBrowse link ISS 6 26,931,969 26,937,789 RGD:5508809 RGD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link Susceptibility ISS 13 64,427,288 64,432,978 RGD:1625347 RGD
G Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C GBrowse link ISS 4 13,739,659 13,914,636 RGD:1580085 RGD
G Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C GBrowse link ISS 4 13,739,659 13,914,636 RGD:1580084 RGD
G Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 GBrowse link IEP 6 127,998,617 128,021,719 RGD:2324964 RGD
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b GBrowse link IEP 15 50,138,439 50,163,254 RGD:2290500 RGD
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 GBrowse link IEP 2 113,204,303 113,221,550 RGD:2290500 RGD
Osteoarthritis with Mild Chondrodysplasia term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Col2a1 collagen, type II, alpha 1 GBrowse link ISS 7 136,679,219 136,707,976 RGD:7240710 OMIM
Osteoarthritis, Hip term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Col1a1 collagen, type I, alpha 1 GBrowse link ISS 10 83,622,438 83,639,368 RGD:5688305 RGD
G Col1a1 collagen, type I, alpha 1 GBrowse link Susceptibility ISS 10 83,622,438 83,639,368 RGD:5688306 RGD
G Col1a1 collagen, type I, alpha 1 GBrowse link No_Association ISS 10 83,622,438 83,639,368 RGD:5688330 RGD
Osteoarthritis, Knee term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G B2m beta-2 microglobulin GBrowse link ISS 3 108,927,919 108,932,718 RGD:6482710 RGD
G Bglap bone gamma-carboxyglutamate (gla) protein GBrowse link ISS 2 180,482,313 180,483,290 RGD:6483563 RGD
G Bglap bone gamma-carboxyglutamate (gla) protein GBrowse link IED 2 180,482,313 180,483,290 RGD:6483595 RGD
G Cd36 CD36 molecule (thrombospondin receptor) GBrowse link IEP 4 13,471,878 13,525,620 RGD:6893565 RGD
G Cd36 CD36 molecule (thrombospondin receptor) GBrowse link Disease_progression ISS 4 13,471,878 13,525,620 RGD:6893494 RGD
G Dkk1 dickkopf 1 homolog (Xenopus laevis) GBrowse link IPM 1 234,392,743 234,396,426 RGD:6907382 RGD
G F2 coagulation factor II GBrowse link ISS 3 76,005,318 76,018,603 RGD:5147774 RGD
G Il4 interleukin 4 GBrowse link IED 10 39,074,582 39,080,134 RGD:2317291 RGD
G Ptges prostaglandin E synthase GBrowse link IEP 3 9,946,194 9,957,538 RGD:2300093 RGD
G Tgfa transforming growth factor alpha GBrowse link IEP 4 120,355,649 120,437,772 RGD:2317486 RGD
G Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor GBrowse link IEA 7 136,567,614 136,617,280 RGD:1331525 RGD
OSTEOCHONDRITIS DISSECANS, SHORT STATURE, AND EARLY-ONSET OSTEOARTHRITIS term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Acan aggrecan GBrowse link ISS 1 134,787,341 134,848,992 RGD:7240710 OMIM
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Term Annotations click to browse term
  Diseases 30466
    Musculoskeletal Diseases 1864
      Rheumatic Diseases 353
        Osteoarthritis 53
          Brachydactylous dwarfism Mseleni type 0
          Chondrocalcinosis 1 0
          Digital Arthropathy-Brachydactyly, Familial 0
          OSTEOCHONDRITIS DISSECANS, SHORT STATURE, AND EARLY-ONSET OSTEOARTHRITIS 1
          Osteoarthritis with Mild Chondrodysplasia 1
          Osteoarthritis, Hip 3
          Osteoarthritis, Knee 11
          Osteoarthritis, Spine 0
Path 2
Term Annotations click to browse term
  Diseases 30466
    Musculoskeletal Diseases 1864
      Joint Diseases 672
        Arthritis 614
          Osteoarthritis 53
            Brachydactylous dwarfism Mseleni type 0
            Chondrocalcinosis 1 0
            Digital Arthropathy-Brachydactyly, Familial 0
            OSTEOCHONDRITIS DISSECANS, SHORT STATURE, AND EARLY-ONSET OSTEOARTHRITIS 1
            Osteoarthritis with Mild Chondrodysplasia 1
            Osteoarthritis, Hip 3
            Osteoarthritis, Knee 11
            Osteoarthritis, Spine 0
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