ONTOLOGY REPORT - ANNOTATIONS
Term: Lung Neoplasms
Accession: RDO:0001202
browse the term
Definition: Tumors or cancer of the LUNG.
Synonyms: exact_synonym: ADENOCARCINOMA OF LUNG; ADENOCARCINOMA OF LUNG, SUSCEPTIBILITY TO; ALVEOLAR CELL CARCINOMA; Cancer of Lung; Cancer of the Lung; LNCR1; LNCR2; LNCR3; LNCR4; LNCR5; LUNG CANCER SUSCEPTIBILITY 1; LUNG CANCER SUSCEPTIBILITY 3; LUNG CANCER SUSCEPTIBILITY 4; LUNG CANCER SUSCEPTIBILITY 5; LUNG CANCER, PROTECTION AGAINST; Lung Cancer; Lung Cancers; Lung Neoplasm; NICOTINE DEPENDENCE, SUSCEPTIBILITY TO LUNG CANCER SUSCEPTIBILITY 2; NONSMALL CELL LUNG CANCER; Pulmonary Cancer; Pulmonary Cancers; Pulmonary Neoplasm; Pulmonary Neoplasms; SMOKING AS A QUANTITATIVE TRAIT LOCUS 3; SQTL3
primary_id: MESH:D008175
alt_id: OMIM:211980 ; OMIM:608935 ; OMIM:612052 ; OMIM:612571 ; OMIM:612593 ; OMIM:614210
Lung Neoplasms
G
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Susceptibility
ISS
10
95,361,338
95,381,455
RGD:4140486
RGD
G
Ager
advanced glycosylation end product-specific receptor
IEA
20
4,250,613
4,253,540
RGD:1331525
RGD
G
Alox12
arachidonate 12-lipoxygenase
ISS
10
57,080,603
57,092,874
RGD:2313872
RGD
G
Atf2
activating transcription factor 2
ISS
3
56,403,676
56,496,473
RGD:704409
RGD
G
Braf
v-raf murine sarcoma viral oncogene homolog B1
ISS
4
67,117,759
67,243,058
RGD:7240710
OMIM
G
Bsg
basigin (Ok blood group)
ISS
7
11,507,914
11,515,132
RGD:2289059
RGD
G
Cadm1
cell adhesion molecule 1
IEP
8
50,765,645
51,108,962
RGD:2289096
RGD
G
Casp8
caspase 8
ISS
9
57,389,353
57,437,803
RGD:7240710
OMIM
G
Ccl22
chemokine (C-C motif) ligand 22
Disease_progression
ISS
19
10,697,324
10,704,129
RGD:4891472
RGD
G
Cd44
Cd44 molecule
ISS
3
88,022,962
88,110,352
RGD:2289345
RGD
G
Cdh1
cadherin 1
IED
19
36,442,693
36,512,091
RGD:1599556
RGD
G
Cdh13
cadherin 13
IED
19
48,507,173
49,575,123
RGD:2293546
RGD
G
Cdh13
cadherin 13
ISS
19
48,507,173
49,575,123
RGD:734736
RGD
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
IAGP
5
108,908,749
108,916,380
RGD:1298567
RGD
G
Chrna3
cholinergic receptor, nicotinic, alpha 3 (neuronal)
ISS
8
58,570,223
58,583,594
RGD:7240710
OMIM
G
Chrna5
cholinergic receptor, nicotinic, alpha 5 (neuronal)
ISS
8
58,538,002
58,566,388
RGD:7240710
OMIM
G
Ctnna1
catenin (cadherin-associated protein), alpha 1, 102kDa
IEP
18
27,629,915
27,769,360
RGD:2289804
RGD
G
Ctnnb1
catenin (cadherin associated protein), beta 1
Disease_progression
IAGP
8
125,978,161
125,987,670
RGD:2289843
RGD
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
ISS
8
61,462,207
61,468,237
RGD:4892075
RGD
G
Dlc1
deleted in liver cancer 1
ISS
16
59,312,930
59,355,129
RGD:7240710
OMIM
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:5131628
RGD
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:7240710
OMIM
G
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
ISS
10
87,219,157
87,242,919
RGD:7240710
OMIM
G
Ercc2
excision repair cross-complementing rodent repair deficiency, complementation group 2
IEA
RGD:1331525
RGD
G
Ercc6
excision repair cross-complementing rodent repair deficiency, complementation group 6
ISS
16
8,024,881
8,091,587
RGD:7240710
OMIM
G
Fen1
flap structure-specific endonuclease 1
ISS
1
212,688,118
212,692,486
RGD:6484213
RGD
G
Ggt5
gamma-glutamyltransferase 5
IEP
RGD:69846
RGD
G
Gstm1
glutathione S-transferase mu 1
Resistance
ISS
2
203,575,444
203,580,821
RGD:4140941
RGD
G
Gstm1
glutathione S-transferase mu 1
IEA
2
203,575,444
203,580,821
RGD:1331525
RGD
G
Gstt1
glutathione S-transferase theta 1
Susceptibility
ISS
20
13,604,355
13,621,456
RGD:4140924
RGD
G
Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
ISS
1
180,202,791
180,324,718
RGD:2317633
RGD
G
Igf2r
insulin-like growth factor 2 receptor
IAGP
1
42,253,273
42,341,646
RGD:1298968
RGD
G
Irf1
interferon regulatory factor 1
ISS
10
39,220,600
39,227,602
RGD:7240710
OMIM
G
Kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
ISS
4
182,869,242
182,895,106
RGD:1600465
RGD
G
Kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
ISS
4
182,869,242
182,895,106
RGD:7240710
OMIM
G
Map3k8
mitogen-activated protein kinase kinase kinase 8
ISS
17
61,910,179
61,930,459
RGD:7240710
OMIM
G
Mbl2
mannose-binding lectin (protein C) 2
Susceptibility
ISS
1
233,978,931
233,983,824
RGD:4889433
RGD
G
Mmp1
matrix metallopeptidase 1 (interstitial collagenase)
No_Association
ISS
8
4,333,773
4,354,284
RGD:7207056
RGD
G
Mmp1
matrix metallopeptidase 1 (interstitial collagenase)
ISS
8
4,333,773
4,354,284
RGD:5131088
RGD
G
Mmp1
matrix metallopeptidase 1 (interstitial collagenase)
ISS
8
4,333,773
4,354,284
RGD:4890379
RGD
G
Mmp1
matrix metallopeptidase 1 (interstitial collagenase)
Susceptibility
ISS
8
4,333,773
4,354,284
RGD:7207021
RGD
G
Mmp2
matrix metallopeptidase 2
Severity
ISS
19
15,246,036
15,275,061
RGD:5130739
RGD
G
Mmp3
matrix metallopeptidase 3
ISS
8
4,315,601
4,329,146
RGD:5129491
RGD
G
Mmp7
matrix metallopeptidase 7
ISS
8
4,526,018
4,533,730
RGD:5129528
RGD
G
Mmp9
matrix metallopeptidase 9
ISS
3
155,985,473
155,993,433
RGD:5129491
RGD
G
Mmp9
matrix metallopeptidase 9
ISS
3
155,985,473
155,993,433
RGD:5130173
RGD
G
Mpo
myeloperoxidase
ISS
10
76,085,872
76,097,012
RGD:5131088
RGD
G
Muc1
mucin 1, cell surface associated
ISS
2
181,399,482
181,403,640
RGD:5131260
RGD
G
Muc4
mucin 4, cell surface associated
Disease_progression
ISS
11
69,830,276
69,858,366
RGD:5131208
RGD
G
Muc4
mucin 4, cell surface associated
ISS
11
69,830,276
69,858,366
RGD:5131258
RGD
G
Nat1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
Susceptibility
ISS
16
23,845,894
23,876,528
RGD:5131605
RGD
G
Nat1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
No_Association
ISS
16
23,845,894
23,876,528
RGD:5131861
RGD
G
Nat2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Susceptibility
IAGP
16
23,855,555
23,876,531
RGD:5131866
RGD
G
Nod2
nucleotide-binding oligomerization domain containing 2
Susceptibility
ISS
19
19,662,337
19,697,341
RGD:5131514
RGD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
Susceptibility
ISS
19
37,251,147
37,266,040
RGD:5134987
RGD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
Susceptibility
ISS
19
37,251,147
37,266,040
RGD:5134963
RGD
G
Park2
parkinson protein 2, E3 ubiquitin protein ligase
ISS
1
43,151,265
44,374,470
RGD:7240710
OMIM
G
Pdgfrb
platelet derived growth factor receptor, beta polypeptide
ISS
18
57,014,475
57,053,581
RGD:2292176
RGD
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISS
2
118,640,277
118,672,440
RGD:2290476
RGD
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISS
2
118,640,277
118,672,440
RGD:7240710
OMIM
G
Plau
plasminogen activator, urokinase
Severity
ISS
15
3,680,072
3,686,232
RGD:7241261
RGD
G
Ppp2r1b
protein phosphatase 2, regulatory subunit A, beta
ISS
8
54,208,126
54,229,044
RGD:7240710
OMIM
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IPM
13
64,427,288
64,432,978
RGD:5135048
RGD
G
Rassf1
Ras association (RalGDS/AF-6) domain family member 1
ISS
8
112,798,863
112,810,004
RGD:2291977
RGD
G
Rassf1
Ras association (RalGDS/AF-6) domain family member 1
ISS
8
112,798,863
112,810,004
RGD:2291979
RGD
G
Rassf1
Ras association (RalGDS/AF-6) domain family member 1
ISS
8
112,798,863
112,810,004
RGD:7240710
OMIM
G
Recql
RecQ protein-like (DNA helicase Q1-like)
ISS
4
179,927,255
179,951,742
RGD:2317370
RGD
G
Scgb3a2
secretoglobin, family 3A, member 2
ISS
18
37,200,474
37,203,396
RGD:5147392
RGD
G
Scgb3a2
secretoglobin, family 3A, member 2
ISS
18
37,200,474
37,203,396
RGD:5147390
RGD
G
Sftpb
surfactant protein B
Susceptibility
ISS
4
105,609,410
105,618,452
RGD:4143389
RGD
G
Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
ISS
8
20,720,915
20,812,157
RGD:2302526
RGD
G
Sod2
superoxide dismutase 2, mitochondrial
ISS
1
41,862,997
41,870,327
RGD:1581247
RGD
G
Strap
serine/threonine kinase receptor associated protein
ISS
4
174,863,502
174,877,750
RGD:1581429
RGD
G
Tlr9
toll-like receptor 9
ISS
RGD:5130705
RGD
G
Tnc
tenascin C
ISS
RGD:4889612
RGD
G
Tp53
tumor protein p53
IEA
10
56,399,721
56,411,150
RGD:1331525
RGD
G
Tp73
tumor protein p73
ISS
5
170,848,979
171,078,739
RGD:2291830
RGD
Adenocarcinoma of lung
G
Myc
myelocytomatosis oncogene
ISS
7
98,953,142
98,958,060
RGD:7207787
RGD
G
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
ISS
6
128,461,775
128,469,309
RGD:5147446
RGD
Adenocarcinoma, Bronchiolo-Alveolar
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:5131630
RGD
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:5131465
RGD
G
Egr1
early growth response 1
ISS
18
27,343,919
27,346,117
RGD:5131942
RGD
G
Gstp1
glutathione S-transferase pi 1
ISS
1
206,627,398
206,629,866
RGD:4140940
RGD
Bronchial Neoplasms
G
Icam1
intercellular adhesion molecule 1
ISS
8
20,040,177
20,051,939
RGD:4145523
RGD
Carcinoma, Bronchogenic
G
Gstp1
glutathione S-transferase pi 1
ISS
1
206,627,398
206,629,866
RGD:4142527
RGD
G
Il10
interleukin 10
ISS
13
43,953,900
43,957,766
RGD:4143231
RGD
G
Il1rn
interleukin 1 receptor antagonist
ISS
3
2,607,800
2,613,216
RGD:4143231
RGD
Carcinoma, Large Cell
G
Met
met proto-oncogene
Severity
ISS
4
43,134,183
43,211,355
RGD:2317441
RGD
G
Prkca
protein kinase C, alpha
ISS
10
97,367,196
97,638,910
RGD:2292463
RGD
G
Strap
serine/threonine kinase receptor associated protein
ISS
4
174,863,502
174,877,750
RGD:1581429
RGD
Carcinoma, Non-Small-Cell Lung
G
Ager
advanced glycosylation end product-specific receptor
ISS
20
4,250,613
4,253,540
RGD:7245515
RGD
G
Akt1
v-akt murine thymoma viral oncogene homolog 1
ISS
6
137,640,482
137,657,552
RGD:5133243
RGD
G
Braf
v-raf murine sarcoma viral oncogene homolog B1
ISS
4
67,117,759
67,243,058
RGD:5133243
RGD
G
Braf
v-raf murine sarcoma viral oncogene homolog B1
ISS
4
67,117,759
67,243,058
RGD:5133242
RGD
G
Cda
cytidine deaminase
ISS
5
157,117,303
157,143,989
RGD:2316365
RGD
G
Cdh13
cadherin 13
ISS
19
48,507,173
49,575,123
RGD:2293545
RGD
G
Chi3l1
chitinase 3-like 1 (cartilage glycoprotein-39)
Severity
ISS
13
47,139,658
47,147,591
RGD:4892660
RGD
G
Cmpk1
cytidine monophosphate (UMP-CMP) kinase 1
Severity
ISS
5
135,320,845
135,348,973
RGD:5133252
RGD
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:5133241
RGD
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:5131629
RGD
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:5133242
RGD
G
Egfr
epidermal growth factor receptor
ISS
14
97,617,358
97,788,211
RGD:1601010
RGD
G
Egfr
epidermal growth factor receptor
Susceptibility
ISS
14
97,617,358
97,788,211
RGD:5131640
RGD
G
Egr1
early growth response 1
Resistance
ISS
18
27,343,919
27,346,117
RGD:5131925
RGD
G
Ephx1
epoxide hydrolase 1, microsomal (xenobiotic)
Disease_progression
ISS
13
96,722,973
96,752,940
RGD:4889124
RGD
G
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
ISS
10
87,219,157
87,242,919
RGD:5133243
RGD
G
Esr1
estrogen receptor 1
ISS
1
35,523,680
35,759,891
RGD:4892255
RGD
G
Gstp1
glutathione S-transferase pi 1
Susceptibility
ISS
1
206,627,398
206,629,866
RGD:4140944
RGD
G
Gstp1
glutathione S-transferase pi 1
ISS
1
206,627,398
206,629,866
RGD:4140950
RGD
G
Icam1
intercellular adhesion molecule 1
Disease_progression
ISS
8
20,040,177
20,051,939
RGD:4145465
RGD
G
Il18
interleukin 18
ISS
8
53,936,584
53,943,228
RGD:4889836
RGD
G
Il1a
interleukin 1 alpha
ISS
3
116,913,612
116,924,114
RGD:4142793
RGD
G
Il1b
interleukin 1 beta
Susceptibility
ISS
3
116,964,422
116,970,867
RGD:4143167
RGD
G
Il1rn
interleukin 1 receptor antagonist
Susceptibility
ISS
3
2,607,800
2,613,216
RGD:4143167
RGD
G
Irf1
interferon regulatory factor 1
ISS
10
39,220,600
39,227,602
RGD:1600014
RGD
G
Itgb3
integrin, beta 3
ISS
RGD:5037228
RGD
G
Kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
ISS
4
182,869,242
182,895,106
RGD:5133242
RGD
G
Lep
leptin
ISS
4
55,943,837
55,945,938
RGD:5128815
RGD
G
Lta
lymphotoxin alpha (TNF superfamily, member 1)
ISS
20
3,657,842
3,659,848
RGD:4143264
RGD
G
Ltf
lactotransferrin
ISS
8
115,417,764
115,440,609
RGD:7243860
RGD
G
Manf
mesencephalic astrocyte-derived neurotrophic factor
Susceptibility
ISS
8
112,111,358
112,113,311
RGD:1599219
RGD
G
Map2k1
mitogen activated protein kinase kinase 1
ISS
8
68,379,074
68,451,554
RGD:5133243
RGD
G
Map2k1
mitogen activated protein kinase kinase 1
ISS
8
68,379,074
68,451,554
RGD:5133242
RGD
G
Met
met proto-oncogene
ISS
4
43,134,183
43,211,355
RGD:5133242
RGD
G
Met
met proto-oncogene
ISS
4
43,134,183
43,211,355
RGD:5133241
RGD
G
Met
met proto-oncogene
ISS
4
43,134,183
43,211,355
RGD:5133243
RGD
G
Mif
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
ISS
20
13,191,986
13,192,851
RGD:4891022
RGD
G
Mmp7
matrix metallopeptidase 7
ISS
8
4,526,018
4,533,730
RGD:5129528
RGD
G
Mmp9
matrix metallopeptidase 9
Disease_progression
IEP
3
155,985,473
155,993,433
RGD:5129215
RGD
G
Nat2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Susceptibility
ISS
16
23,855,555
23,876,531
RGD:4140950
RGD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
Disease_progression
ISS
19
37,251,147
37,266,040
RGD:5133265
RGD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
ISS
19
37,251,147
37,266,040
RGD:5133268
RGD
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISS
2
118,640,277
118,672,440
RGD:5133243
RGD
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISS
2
118,640,277
118,672,440
RGD:5133242
RGD
G
Plau
plasminogen activator, urokinase
ISS
15
3,680,072
3,686,232
RGD:4892055
RGD
G
Pten
phosphatase and tensin homolog
ISS
1
236,771,027
236,837,261
RGD:5133242
RGD
G
Ptges
prostaglandin E synthase
Severity
ISS
3
9,946,194
9,957,538
RGD:5135302
RGD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
Severity
ISS
13
64,427,288
64,432,978
RGD:5135471
RGD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
Severity
ISS
13
64,427,288
64,432,978
RGD:5135302
RGD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
ISS
1
208,262,669
208,273,148
RGD:2298765
RGD
G
Robo1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
IEP
11
10,784,947
11,720,646
RGD:2314868
RGD
G
Scgb3a2
secretoglobin, family 3A, member 2
ISS
18
37,200,474
37,203,396
RGD:5147390
RGD
G
Sftpd
surfactant protein D
Disease_progression
ISS
RGD:4143490
RGD
G
Spp1
secreted phosphoprotein 1
ISS
RGD:1581361
RGD
G
Thbd
thrombomodulin
Disease_progression
ISS
3
137,158,955
137,162,607
RGD:5685035
RGD
G
Tk1
thymidine kinase 1, soluble
ISS
RGD:2317237
RGD
G
Tlr9
toll-like receptor 9
ISS
RGD:5130185
RGD
G
Tnf
tumor necrosis factor
ISS
20
3,661,000
3,663,618
RGD:4142793
RGD
G
Tnf
tumor necrosis factor
ISS
20
3,661,000
3,663,618
RGD:4143264
RGD
G
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
Severity
ISS
4
162,172,563
162,185,252
RGD:5131202
RGD
G
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
Disease_progression
ISS
4
162,172,563
162,185,252
RGD:5131156
RGD
G
Tp53
tumor protein p53
ISS
10
56,399,721
56,411,150
RGD:5133242
RGD
G
Tymp
thymidine phosphorylase
ISS
7
127,666,518
127,671,624
RGD:2325156
RGD
Pleuropulmonary blastoma
G
Dicer1
dicer 1, ribonuclease type III
ISS
6
128,777,468
128,838,780
RGD:7240710
OMIM
Pulmonary Blastoma
G
Dicer1
dicer 1, ribonuclease type III
ISS
6
128,777,468
128,838,780
RGD:7240710
OMIM
Small Cell Lung Carcinoma
G
Mthfr
methylenetetrahydrofolate reductase (NAD(P)H)
Severity
ISS
5
165,112,850
165,126,885
RGD:4891158
RGD
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest