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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:vitamin K cycle pathway
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Accession:PW:0002592 term browser browse the term
Definition:The vitamin K cycle is an essential aspect of its metabolism. The carboxylation of glutamate residues in vitamin K-dependent (VKD) proteins, necessary for their function, requires a reduced form of vitamin K as a cofactor. The resulting oxidized compound is converted back to the reduced form via a two-step reduction reaction. Natural and synthetic antagonists block the cycle and thus, the VKD protein modification. VKD proteins include coagulation factors; antagonists are used as anti-coagulation, anti-thrombotic agents.
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vitamin K cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggcx gamma-glutamyl carboxylase ISO RGD PMID:26663892 RGD:11344916 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO RGD PMID:26663892 RGD:11344916 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      metabolic pathway of cofactors, vitamins, nutrients 367
        fat-soluble vitamin metabolic pathway 101
          vitamin K metabolic pathway 4
            vitamin K cycle pathway 2
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