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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nicotinamide adenine dinucleotide metabolic pathway
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Accession:PW:0002580 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis and utilization of nicotinamide adenine dinucleotide (NAD). There are several routes leading to NAD biosynthesis from various sources. NAD, in addition to its well known role as a cofactor in redox reactions, also serves as a substrate for several classes of enzymes.
Synonyms:exact_synonym: NAD metabolic pathway
 related_synonym: SMP:00124;   SMP:00129
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nicotinamide adenine dinucleotide metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO SMPDB SMP:00124 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:18020963 PMID:16368075 RGD:5129954, RGD:11251688 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00129, RGD:5129954, RGD:11251688 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00124, RGD:5129954, RGD:11251688 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00124, RGD:5129954, RGD:11251688 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Mdh1 malate dehydrogenase 1 ISO RGD PMID:18020963 PMID:16368075 RGD:5129954, RGD:11251688 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mdh2 malate dehydrogenase 2 ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00129, RGD:5129954, RGD:11251688 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Nadk NAD kinase ISO RGD PMID:25641397 RGD:11250407 NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322 		JBrowse link
G Nadk2 NAD kinase 2, mitochondrial ISO RGD PMID:25641397 RGD:11250407 NCBI chr 2:58,117,674...58,159,815
Ensembl chr 2:58,117,674...58,159,808 		JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 ISO RGD PMID:18020963 PMID:16368075 RGD:5129954, RGD:11251688 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Slc22a13 solute carrier family 22 member 13 ISO RGD PMID:25837229 RGD:11251687 NCBI chr 8:118,922,367...118,934,020
Ensembl chr 8:118,922,367...118,953,635 		JBrowse link
G Slc25a11 solute carrier family 25 member 11 ISO SMPDB SMP:00129 NCBI chr10:55,357,590...55,360,441
Ensembl chr10:55,357,597...55,360,410 		JBrowse link
G Slc25a12 solute carrier family 25 member 12 ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00129, RGD:5129954, RGD:11251688 NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100 		JBrowse link
G Slc25a13 solute carrier family 25 member 13 ISO RGD PMID:16368075 RGD:11251688 NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902 		JBrowse link
G Slc36a4 solute carrier family 36 member 4 ISO RGD PMID:25837229 RGD:11251687 NCBI chr 8:12,519,613...12,552,671
Ensembl chr 8:12,519,943...12,552,031 		JBrowse link
G Slc5a8 solute carrier family 5 member 8 ISO RGD PMID:25837229 RGD:11251687 NCBI chr 7:23,272,891...23,313,811
Ensembl chr 7:23,272,427...23,314,642 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO RGD PMID:25837229 RGD:11251687 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
ADP-ribosylation pathway, cyclic ribosylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bst1 bone marrow stromal cell antigen 1 ISO RGD PMID:23576305 RGD:11250406 NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180 		JBrowse link
G Cd38 CD38 molecule ISO RGD PMID:23576305 RGD:11250406 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
ADP-ribosylation pathway, mono and poly-ribosylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains ISO RGD PMID:26091342 RGD:11100038 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716 		JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492 		JBrowse link
G Oard1 O-acyl-ADP-ribose deacylase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 9:12,576,894...12,587,264
Ensembl chr 9:12,578,970...12,587,249 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase ISO RGD PMID:26091342 RGD:11100038 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 7:107,949,031...107,958,377
Ensembl chr 7:107,949,043...107,958,304 		JBrowse link
G Parp11 poly (ADP-ribose) polymerase family, member 11 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:160,298,040...160,344,369
Ensembl chr 4:160,304,905...160,341,946 		JBrowse link
G Parp12 poly (ADP-ribose) polymerase family, member 12 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:67,826,548...67,885,356
Ensembl chr 4:67,839,237...67,883,685 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 ISO RGD PMID:26091342 RGD:11100038 NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916 		JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 ISO RGD PMID:26091342 RGD:11100038 NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810 		JBrowse link
G Parp6 poly (ADP-ribose) polymerase family, member 6 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 8:60,016,594...60,049,108
Ensembl chr 8:60,016,877...60,049,108 		JBrowse link
G Parp8 poly (ADP-ribose) polymerase family, member 8 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 2:48,679,405...48,848,700
Ensembl chr 2:48,679,436...48,849,253 		JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 ISO RGD PMID:26091342 RGD:11100038 NCBI chr11:64,780,977...64,814,995
Ensembl chr11:64,780,981...64,815,455 		JBrowse link
G Rnf146 ring finger protein 146 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 1:28,458,864...28,475,758
Ensembl chr 1:28,458,887...28,475,923 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase ISO RGD PMID:26091342 RGD:11100038 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Tnks tankyrase ISO RGD PMID:26091342 RGD:11100038 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260 		JBrowse link
G Tnks2 tankyrase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 1:234,567,888...234,621,079
Ensembl chr 1:234,567,858...234,621,079 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428 		JBrowse link
de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nadsyn1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180 		JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645 		JBrowse link
G Qprt quinolinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:181,718,189...181,733,486
Ensembl chr 1:181,718,190...181,733,486 		JBrowse link
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nadsyn1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Naprt nicotinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:107,576,645...107,580,102
Ensembl chr 7:107,576,627...107,580,102 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180 		JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645 		JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791 		JBrowse link
G Nmrk2 nicotinamide riboside kinase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:8,514,855...8,517,916
Ensembl chr 7:8,514,927...8,517,922 		JBrowse link
Sirtuin mediated pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 ISO RGD PMID:26785480 RGD:11100032 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt3 sirtuin 3 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sirt4 sirtuin 4 ISO RGD PMID:26785480 RGD:11100032 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Sirt5 sirtuin 5 ISO RGD PMID:26785480 RGD:11100032 NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101 		JBrowse link
G Sirt6 sirtuin 6 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Sirt7 sirtuin 7 ISO RGD PMID:26785480 RGD:11100032 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      metabolic pathway of cofactors, vitamins, nutrients 367
        nicotinamide adenine dinucleotide metabolic pathway 59
          nicotinamide adenine dinucleotide biosynthetic pathway + 9
          nicotinamide adenine nucleotide utilization pathway + 32
paths to the root