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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mitochondrial protein import pathway
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Accession:PW:0001962 term browser browse the term
Definition:Mitochondria are essential organelles that provide most of the ATP fuel for the cell, are the site of several important metabolic pathways and play essential roles in calcium storage, signaling and apoptosis. Of the many proteins involved, only 13 are encoded in the mammalian mitochondrial DNA. The remaining ~99% of mitochondrial proteins are translocated from the cytosol via a complex, multicomponent pathway system. Mitochondria-encoded proteins are translocated from the mitochondrial matrix into the inner mitochondrial membrane by a single system.
Synonyms:related_synonym: Mitochondrial protein import;   protein targeting to mitochondrion
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show annotations for term's descendants           Sort by:
mitochondrial protein import pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoo apolipoprotein O contributes_to ISO RGD PMID:23109542 RGD:10412671 NCBI chr  X:59,157,971...59,262,940
Ensembl chr  X:59,158,049...59,262,940 		JBrowse link
G Apool apolipoprotein O-like contributes_to ISO RGD PMID:23109542 RGD:10412671 NCBI chr  X:77,377,723...77,443,672
Ensembl chr  X:77,377,781...77,443,900 		JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 contributes_to ISO RGD PMID:23109542 RGD:10412671 NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847 		JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 contributes_to ISO RGD PMID:23109542 RGD:10412671 NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216 		JBrowse link
G Immt inner membrane mitochondrial protein contributes_to ISO RGD PMID:23109542 RGD:10412671 NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109 		JBrowse link
G Micos10 mitochondrial contact site and cristae organizing system subunit 10 contributes_to ISO RGD PMID:23109542 RGD:10412671 NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485 		JBrowse link
G Oxa1l OXA1L, mitochondrial inner membrane protein ISO RGD PMID:25633533 RGD:10412658 NCBI chr15:27,813,688...27,821,319
Ensembl chr15:27,813,625...27,821,319 		JBrowse link
alpha-helical insertion pathway of mitochondrial protein import term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tomm70 translocase of outer mitochondrial membrane 70 ISO RGD PMID:25633533 RGD:10412658 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
beta-barrel pathway of mitochondrial protein import term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtx1 Metaxin 1 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 2:174,615,460...174,621,383
Ensembl chr 2:174,615,461...174,620,982 		JBrowse link
G Mtx2 metaxin 2 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 3:59,730,206...59,792,202
Ensembl chr 3:59,730,197...59,792,201 		JBrowse link
G Samm50 SAMM50 sorting and assembly machinery component ISO RGD PMID:25305573 RGD:10412662 NCBI chr 7:115,317,472...115,341,682
Ensembl chr 7:115,317,404...115,341,682 		JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940 		JBrowse link
G Timm13 translocase of inner mitochondrial membrane 13 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 7:8,809,069...8,810,172
Ensembl chr 7:8,809,058...8,809,910 		JBrowse link
G Timm8a1 translocase of inner mitochondrial membrane 8A1 ISO RGD PMID:25305573 RGD:10412662 NCBI chr  X:97,717,932...97,722,170
Ensembl chr  X:97,717,920...97,721,960 		JBrowse link
G Timm8b translocase of inner mitochondrial membrane 8 homolog B ISO RGD PMID:25305573 RGD:10412662 NCBI chr 8:50,954,350...50,955,730
Ensembl chr 8:50,954,342...50,955,729 		JBrowse link
G Timm9 translocase of inner mitochondrial membrane 9 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 6:89,610,094...89,622,924
Ensembl chr 6:89,610,094...89,622,924 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 ISO RGD PMID:25305573 RGD:10412662 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Tomm22 translocase of outer mitochondrial membrane 22 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 7:111,223,508...111,228,671
Ensembl chr 7:111,216,571...111,246,799 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915 		JBrowse link
G Tomm5 translocase of outer mitochondrial membrane 5 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 5:59,362,360...59,365,191
Ensembl chr 5:59,362,240...59,365,269 		JBrowse link
G Tomm6 translocase of outer mitochondrial membrane 6 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 9:13,304,269...13,305,637 JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 ISO RGD PMID:25305573 RGD:10412662 NCBI chr 4:11,305,122...11,311,963
Ensembl chr 4:11,305,110...11,311,962 		JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 ISO RGD PMID:25305573 RGD:10412662 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
carrier pathway of mitochondrial protein import term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Timm10 translocase of inner mitochondrial membrane 10 ISO RGD PMID:14726512 RGD:10412667 NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940 		JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B ISO RGD PMID:14726512 RGD:10412667 NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642 		JBrowse link
G Timm22 translocase of inner mitochondrial membrane 22 ISO RGD PMID:14726512 RGD:10412667 NCBI chr10:61,253,459...61,261,217
Ensembl chr10:61,253,450...61,261,755 		JBrowse link
G Timm9 translocase of inner mitochondrial membrane 9 ISO RGD PMID:14726512 RGD:10412667 NCBI chr 6:89,610,094...89,622,924
Ensembl chr 6:89,610,094...89,622,924 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 ISO RGD PMID:25980382 RGD:10412661 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Tomm22 translocase of outer mitochondrial membrane 22 ISO RGD PMID:25980382 RGD:10412661 NCBI chr 7:111,223,508...111,228,671
Ensembl chr 7:111,216,571...111,246,799 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO RGD PMID:25980382 RGD:10412661 NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915 		JBrowse link
G Tomm5 translocase of outer mitochondrial membrane 5 ISO RGD PMID:25980382 RGD:10412661 NCBI chr 5:59,362,360...59,365,191
Ensembl chr 5:59,362,240...59,365,269 		JBrowse link
G Tomm6 translocase of outer mitochondrial membrane 6 ISO RGD PMID:25980382 RGD:10412661 NCBI chr 9:13,304,269...13,305,637 JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 ISO RGD PMID:25980382 RGD:10412661 NCBI chr 4:11,305,122...11,311,963
Ensembl chr 4:11,305,110...11,311,962 		JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 ISO RGD PMID:25980382 RGD:10412661 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
intermembrane space assembly pathway of mitochondrial protein import term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 ISO RGD PMID:26214018 RGD:10412663 NCBI chr 4:123,968,264...123,977,398
Ensembl chr 4:123,968,265...123,977,414
Ensembl chr 1:123,968,265...123,977,414 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:26214018 RGD:10412663 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO RGD PMID:25633533 RGD:10412658 NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915 		JBrowse link
presequence pathway of mitochondrial protein import term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 ISO RGD PMID:25542066 RGD:10412659 NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264 		JBrowse link
G Grpel1 GrpE-like 1, mitochondrial ISO RGD PMID:25542066 RGD:10412659 NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200 		JBrowse link
G Grpel2 GrpE-like 2, mitochondrial ISO RGD PMID:25542066 RGD:10412659 NCBI chr18:55,167,831...55,180,073
Ensembl chr18:55,168,209...55,180,180 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25542066 RGD:10412659 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Immp1l inner mitochondrial membrane peptidase subunit 1 ISO RGD PMID:22172993 RGD:10412669 NCBI chr 3:92,385,329...92,449,559
Ensembl chr 3:92,385,379...92,452,313 		JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 ISO RGD PMID:22172993 RGD:10412669 NCBI chr 6:58,070,035...58,970,165
Ensembl chr 6:58,070,283...58,969,840 		JBrowse link
G Mipep mitochondrial intermediate peptidase ISO RGD PMID:22172993 RGD:10412669 NCBI chr15:34,926,198...35,051,722
Ensembl chr15:34,926,207...35,051,727 		JBrowse link
G Pam16 presequence translocase associated motor 16 ISO RGD PMID:25542066 RGD:10412659 NCBI chr10:10,942,534...10,950,654
Ensembl chr10:10,943,001...10,950,649 		JBrowse link
G Pmpca peptidase, mitochondrial processing subunit alpha ISO RGD PMID:22172993 RGD:10412669 NCBI chr 3:9,207,731...9,216,846
Ensembl chr 3:9,207,717...9,216,844 		JBrowse link
G Pmpcb peptidase, mitochondrial processing subunit beta ISO RGD PMID:22172993 RGD:10412669 NCBI chr 4:13,297,583...13,310,363
Ensembl chr 4:13,297,559...13,310,367 		JBrowse link
G Romo1 reactive oxygen species modulator 1 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr 3:144,659,709...144,661,310
Ensembl chr 3:144,659,826...144,661,310 		JBrowse link
G Timm17a translocase of inner mitochondrial membrane 17A ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr13:46,731,117...46,742,604
Ensembl chr13:46,730,660...46,742,655 		JBrowse link
G Timm21 translocase of inner mitochondrial membrane 21 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr18:78,314,900...78,319,362
Ensembl chr18:78,314,909...78,319,454 		JBrowse link
G Timm23 translocase of inner mitochondrial membrane 23 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379 		JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 ISO RGD PMID:25542066 RGD:10412659 NCBI chr12:2,612,581...2,629,374
Ensembl chr12:2,612,581...2,629,351 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr 1:83,574,872...83,582,748
Ensembl chr 1:83,556,757...83,582,793 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Tomm22 translocase of outer mitochondrial membrane 22 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr 7:111,223,508...111,228,671
Ensembl chr 7:111,216,571...111,246,799 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915 		JBrowse link
G Tomm5 translocase of outer mitochondrial membrane 5 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr 5:59,362,360...59,365,191
Ensembl chr 5:59,362,240...59,365,269 		JBrowse link
G Tomm6 translocase of outer mitochondrial membrane 6 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr 9:13,304,269...13,305,637 JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr 4:11,305,122...11,311,963
Ensembl chr 4:11,305,110...11,311,962 		JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 ISO RGD PMID:25633533 PMID:25542066 RGD:10412658, RGD:10412659 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
G Xpnpep3 X-prolyl aminopeptidase 3 ISO RGD PMID:22172993 RGD:10412669 NCBI chr 7:112,926,154...112,978,793
Ensembl chr 7:112,926,248...112,974,878 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        mitochondria homeostasis pathway 112
          mitochondrial protein import pathway 43
            alpha-helical insertion pathway of mitochondrial protein import 1
            beta-barrel pathway of mitochondrial protein import 15
            carrier pathway of mitochondrial protein import 11
            intermembrane space assembly pathway of mitochondrial protein import 3
            presequence pathway of mitochondrial protein import 24
paths to the root