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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mitochondrial autophagy pathway
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Accession:PW:0001842 term browser browse the term
Definition:Damage to mitochondria will promote mitophagy, the mitochondrial autophagy pathway. It exhibits features common to macroautophagy or the regular autophagy, and also features that are distinct. Under more sustained stress, the cell will promote apoptosis. Translocation of cardiolipin, the signature phospholipid of the mitochondrial inner membrane, to the outer membrane, provides a signal of mitochondrial dysfunction.
Synonyms:related_synonym: Mitophagy;   mitophagy pathway
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mitochondrial autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 ISO RGD PMID:23065344 RGD:10401098 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221 		JBrowse link
G Atg7 autophagy related 7 ISO RGD PMID:25840011 RGD:10400888 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Atxn3 ataxin 3 ISO RGD PMID:25995186 RGD:10401790 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Becn1 beclin 1 ISO RGD PMID:23065344 RGD:10401098 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO RGD PMID:25840011 PMID:23065344 RGD:10400888, RGD:10401098 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO RGD PMID:25840011 PMID:23065344 RGD:10400888, RGD:10401098 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO RGD PMID:25840011 RGD:10400888 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO RGD PMID:25840011 RGD:10400888 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Csnk2b casein kinase 2 beta ISO RGD PMID:25840011 RGD:10400888 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Fundc1 FUN14 domain containing 1 ISO RGD PMID:25840011 RGD:10400888 NCBI chr  X:5,083,635...5,100,293
Ensembl chr  X:5,083,617...5,100,284 		JBrowse link
G Optn optineurin ISO RGD PMID:25995186 RGD:10401790 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Parl presenilin associated, rhomboid-like ISO RGD PMID:25526784 RGD:10402124 NCBI chr11:80,594,059...80,620,506
Ensembl chr11:80,593,192...80,620,506 		JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase ISO RGD PMID:25840011 RGD:10400888 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420 		JBrowse link
G Pink1 PTEN induced kinase 1 ISO RGD PMID:25840011 PMID:25995186 PMID:23065344 RGD:10400888, RGD:10401790, RGD:10401098 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:23065344 PMID:25840011 PMID:25995186 RGD:10401098, RGD:10400888, RGD:10401790 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Sqstm1 sequestosome 1 ISO RGD PMID:23065344 PMID:25995186 RGD:10401098, RGD:10401790 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:25840011 RGD:10400888 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 ISO RGD PMID:25526784 RGD:10402124 NCBI chr 4:11,305,122...11,311,963
Ensembl chr 4:11,305,110...11,311,962 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 ISO RGD PMID:25995186 RGD:10401790 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO RGD PMID:25840011 RGD:10400888 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 ISO RGD PMID:25995186 RGD:10401790 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721 		JBrowse link
G Usp30 ubiquitin specific peptidase 30 ISO RGD PMID:25995186 RGD:10401790 NCBI chr12:42,501,345...42,555,311
Ensembl chr12:42,501,348...42,555,616 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO RGD PMID:25995186 RGD:10401790 NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666 		JBrowse link
altered mitochondrial autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pink1 PTEN induced kinase 1 ISO RGD PMID:24735649 RGD:10450527 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24735649 RGD:10450527 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        mitochondria homeostasis pathway 112
          mitochondrial autophagy pathway 23
            altered mitochondrial autophagy pathway 2
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      cell death pathway 243
        programmed cell death pathway 243
          non-apoptotic cell death pathway 85
            cellular autophagy pathway 85
              mitochondrial autophagy pathway 23
                altered mitochondrial autophagy pathway 2
paths to the root