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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:organophosphate response pathway
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Accession:PW:0001516 term browser browse the term
Definition:Organophosphates (OPs) represent one of the main classes of pesticides. However, they exert serious adverse effects, primarily affecting the cholinergic nervous system. OPs inhibit acetylcholinesterase, the enzyme that hydrolyzes acetylcholine, a major neurotransmitter in the nervous system and periphery.
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organophosphate response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO RGD PMID:24508992 RGD:8551790 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Alb albumin ISO RGD PMID:23261756 RGD:8551793 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO RGD PMID:22155227 RGD:8551791 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Pon1 paraoxonase 1 ISO RGD PMID:19433263 RGD:8551792 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      cellular detoxification pathway 156
        toxin and toxicant response pathway 23
          organophosphate response pathway 4
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