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Term:interleukin-1 signaling pathway
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Accession:PW:0000883 term browser browse the term
Definition:Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor, allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin 1alpha and beta.
Synonyms:related_synonym: Il-1 signaling pathway;   PID:200089
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interleukin-1 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G AIM2 absent in melanoma 2 GBrowse link TAS 1 159,032,275 159,046,647 RGD:5490211 RGD
G CARD8 caspase recruitment domain family, member 8 GBrowse link TAS 19 48,711,343 48,759,203 RGD:5490210 RGD
G CASP1 caspase 1, apoptosis-related cysteine peptidase GBrowse link TAS 11 104,896,235 104,905,884 RGD:5490210 RGD
G CASP1 caspase 1, apoptosis-related cysteine peptidase GBrowse link TAS 11 104,896,235 104,905,884 RGD:5490211 RGD
G CASP1 caspase 1, apoptosis-related cysteine peptidase GBrowse link EXP 11 104,896,235 104,905,884 RGD:6484113 PID
G CASP5 caspase 5, apoptosis-related cysteine peptidase GBrowse link TAS 11 104,864,967 104,893,895 RGD:5490211 RGD
G CHUK conserved helix-loop-helix ubiquitous kinase GBrowse link EXP 10 101,948,124 101,989,344 RGD:6484113 PID
G ERC1 ELKS/RAB6-interacting/CAST family member 1 GBrowse link EXP 12 1,100,404 1,605,099 RGD:6484113 PID
G IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta GBrowse link EXP 8 42,128,820 42,190,171 RGD:6484113 PID
G IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma GBrowse link EXP X 153,770,459 153,793,261 RGD:6484113 PID
G IL1A interleukin 1, alpha GBrowse link TAS 2 113,531,492 113,542,971 RGD:5490209 RGD
G IL1A interleukin 1, alpha GBrowse link EXP 2 113,531,492 113,542,971 RGD:6484113 PID
G IL1B interleukin 1, beta GBrowse link TAS 2 113,587,337 113,594,356 RGD:5490209 RGD
G IL1B interleukin 1, beta GBrowse link EXP 2 113,587,337 113,594,356 RGD:6484113 PID
G IL1R1 interleukin 1 receptor, type I GBrowse link ISS 2 102,770,402 102,796,334 RGD:5130945 RGD
G IL1R1 interleukin 1 receptor, type I GBrowse link TAS 2 102,770,402 102,796,334 RGD:5490209 RGD
G IL1R1 interleukin 1 receptor, type I GBrowse link EXP 2 102,770,402 102,796,334 RGD:6484113 PID
G IL1R2 interleukin 1 receptor, type II GBrowse link TAS 2 102,608,306 102,644,885 RGD:5490209 RGD
G IL1R2 interleukin 1 receptor, type II GBrowse link EXP 2 102,608,306 102,644,885 RGD:6484113 PID
G IL1RAP interleukin 1 receptor accessory protein GBrowse link TAS 3 190,231,840 190,374,986 RGD:5490209 RGD
G IL1RN interleukin 1 receptor antagonist GBrowse link TAS 2 113,875,470 113,891,593 RGD:5490209 RGD
G IL1RN interleukin 1 receptor antagonist GBrowse link EXP 2 113,875,470 113,891,593 RGD:6484113 PID
G IRAK1 interleukin-1 receptor-associated kinase 1 GBrowse link TAS X 153,275,957 153,285,342 RGD:5490218 RGD
G IRAK1 interleukin-1 receptor-associated kinase 1 GBrowse link TAS X 153,275,957 153,285,342 RGD:5490215 RGD
G IRAK1 interleukin-1 receptor-associated kinase 1 GBrowse link EXP X 153,275,957 153,285,342 RGD:6484113 PID
G IRAK2 interleukin-1 receptor-associated kinase 2 GBrowse link TAS 3 10,206,563 10,285,427 RGD:5490215 RGD
G IRAK3 interleukin-1 receptor-associated kinase 3 GBrowse link EXP 12 66,582,978 66,648,402 RGD:6484113 PID
G IRAK4 interleukin-1 receptor-associated kinase 4 GBrowse link TAS 12 44,152,747 44,183,346 RGD:5490218 RGD
G IRAK4 interleukin-1 receptor-associated kinase 4 GBrowse link TAS 12 44,152,747 44,183,346 RGD:5490215 RGD
G IRAK4 interleukin-1 receptor-associated kinase 4 GBrowse link EXP 12 44,152,747 44,183,346 RGD:6484113 PID
G JUN jun proto-oncogene GBrowse link EXP 1 59,246,463 59,249,785 RGD:6484113 PID
G MAP2K6 mitogen-activated protein kinase kinase 6 GBrowse link EXP 17 67,410,838 67,538,470 RGD:6484113 PID
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 GBrowse link EXP 17 61,699,801 61,773,670 RGD:6484113 PID
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 GBrowse link TAS 6 91,223,292 91,297,020 RGD:5490218 RGD
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 GBrowse link TAS 6 91,223,292 91,297,020 RGD:5490215 RGD
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 GBrowse link EXP 6 91,223,292 91,297,020 RGD:6484113 PID
G MAPK8 mitogen-activated protein kinase 8 GBrowse link EXP 10 49,609,687 49,643,183 RGD:6484113 PID
G MYD88 myeloid differentiation primary response 88 GBrowse link TAS 3 38,179,969 38,184,513 RGD:5490218 RGD
G MYD88 myeloid differentiation primary response 88 GBrowse link TAS 3 38,179,969 38,184,513 RGD:5490215 RGD
G MYD88 myeloid differentiation primary response 88 GBrowse link EXP 3 38,179,969 38,184,513 RGD:6484113 PID
G NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link EXP 4 103,422,486 103,538,459 RGD:6484113 PID
G NLRP1 NLR family, pyrin domain containing 1 GBrowse link TAS 17 5,404,719 5,487,832 RGD:5490211 RGD
G NLRP3 NLR family, pyrin domain containing 3 GBrowse link TAS 1 247,579,458 247,612,410 RGD:5490210 RGD
G NLRP3 NLR family, pyrin domain containing 3 GBrowse link TAS 1 247,579,458 247,612,410 RGD:5490211 RGD
G PELI1 pellino E3 ubiquitin protein ligase 1 GBrowse link TAS 2 64,319,786 64,371,605 RGD:5490215 RGD
G PELI2 pellino E3 ubiquitin protein ligase family member 2 GBrowse link TAS 14 56,585,093 56,768,031 RGD:5490215 RGD
G PELI3 pellino E3 ubiquitin protein ligase family member 3 GBrowse link TAS 11 66,233,798 66,244,808 RGD:5490215 RGD
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link EXP 3 178,866,311 178,952,500 RGD:6484113 PID
G PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link EXP 5 67,511,584 67,597,649 RGD:6484113 PID
G PRKCI protein kinase C, iota GBrowse link EXP 3 169,940,220 170,023,770 RGD:6484113 PID
G PRKCZ protein kinase C, zeta GBrowse link EXP 1 1,981,909 2,116,834 RGD:6484113 PID
G PYCARD PYD and CARD domain containing GBrowse link TAS 16 31,212,807 31,214,097 RGD:5490210 RGD
G PYCARD PYD and CARD domain containing GBrowse link TAS 16 31,212,807 31,214,097 RGD:5490211 RGD
G RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link EXP 11 65,421,067 65,430,443 RGD:6484113 PID
G SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain GBrowse link TAS 11 405,716 417,397 RGD:5490209 RGD
G SQSTM1 sequestosome 1 GBrowse link EXP 5 179,233,388 179,265,078 RGD:6484113 PID
G TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 GBrowse link TAS 22 39,795,759 39,833,132 RGD:5490218 RGD
G TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 GBrowse link TAS 22 39,795,759 39,833,132 RGD:5490215 RGD
G TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 GBrowse link EXP 22 39,795,759 39,833,132 RGD:6484113 PID
G TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 GBrowse link TAS 6 149,639,436 149,732,747 RGD:5490218 RGD
G TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 GBrowse link TAS 6 149,639,436 149,732,747 RGD:5490215 RGD
G TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 GBrowse link EXP 6 149,639,436 149,732,747 RGD:6484113 PID
G TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 GBrowse link TAS X 30,845,559 30,907,511 RGD:5490218 RGD
G TICAM2 toll-like receptor adaptor molecule 2 GBrowse link EXP 5 114,914,339 114,938,176 RGD:6484113 PID
G TMED7-TICAM2 TMED7-TICAM2 readthrough GBrowse link EXP 5 114,914,339 114,961,876 RGD:6484113 PID
G TOLLIP toll interacting protein GBrowse link TAS 11 1,295,598 1,330,892 RGD:5490218 RGD
G TOLLIP toll interacting protein GBrowse link EXP 11 1,295,598 1,330,892 RGD:6484113 PID
G TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase GBrowse link ISS 11 36,505,317 36,531,863 RGD:5130945 RGD
G TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase GBrowse link TAS 11 36,505,317 36,531,863 RGD:5490218 RGD
G TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase GBrowse link TAS 11 36,505,317 36,531,863 RGD:5490215 RGD
G TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase GBrowse link EXP 11 36,505,317 36,531,863 RGD:6484113 PID
G UBE2N ubiquitin-conjugating enzyme E2N GBrowse link TAS 12 93,802,088 93,836,026 RGD:5490218 RGD
G UBE2N ubiquitin-conjugating enzyme E2N GBrowse link TAS 12 93,802,088 93,836,026 RGD:5490215 RGD
G UBE2N ubiquitin-conjugating enzyme E2N GBrowse link EXP 12 93,802,088 93,836,026 RGD:6484113 PID
G UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 GBrowse link TAS 20 48,697,661 48,732,496 RGD:5490218 RGD
G UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 GBrowse link TAS 20 48,697,661 48,732,496 RGD:5490215 RGD
G UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 GBrowse link EXP 20 48,697,661 48,732,496 RGD:6484113 PID
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  Pathway Ontology 15791
    signaling pathway 6748
      cytokine and chemokine mediated signaling pathway 713
        cytokine mediated signaling pathway 712
          Interleukin mediated signaling pathway 478
            interleukin-1 family mediated signaling pathway 77
              interleukin-1 signaling pathway 77
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