ONTOLOGY REPORT - ANNOTATIONS

Term:gefitinib pharmacodynamics pathway
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Accession:PW:0000871 term browser browse the term
Definition:The pathway of gefitinib-target interactions and of the biochemical or physiological responses to drug. Gefitinib is the first selective inhibitor of EGFR whose mutations within the tyrosine kinase domain have been associated with hyperactive epidermal growth factor signaling in non-small cell lung cancers. Genetic variations can cause differences in the response of the organism to the drug.
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gefitinib pharmacodynamics pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Egfr epidermal growth factor receptor GBrowse link ISS 14 97,617,358 97,788,211 RGD:5135288 RGD
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Path 1
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  Pathway Ontology 17140
    drug pathway 19
      antineoplastic and immunomodulatory drug pathway 14
        gefitinib drug pathway 1
          gefitinib pharmacodynamics pathway 1
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