ONTOLOGY REPORT - ANNOTATIONS

Term:tamoxifen pharmacokinetics pathway
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Accession:PW:0000838 term browser browse the term
Definition:The pathway of processing - absorption, distribution, metabolism or elimination - of tamoxifen - a SERM anti-estrogen drug. Genetic variations can result in changes in the availability of the drug. For instance, variation in CYP2D6, an important enzyme for the production of a primary drug metabolite, impacts on the available concentration of the drug.
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tamoxifen pharmacokinetics pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link IDA 12 9,517,016 9,541,000 RGD:5129544 RGD
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 GBrowse link IDA 12 9,567,120 9,595,974 RGD:5129544 RGD
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 GBrowse link IDA 1 75,632,632 75,708,022 RGD:5129555 RGD
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  Pathway Ontology 17140
    drug pathway 19
      antineoplastic and immunomodulatory drug pathway 14
        anti-estrogen drug pathway 10
          tamoxifen drug pathway 9
            tamoxifen pharmacokinetics pathway 3
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