Toll-like receptor signaling pathway - Ontology Report

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Term:	Toll-like receptor signaling pathway	go back to main search page
Accession:	PW:0000814	browse the term
Definition:	Toll-like receptors represent a large and the better understood family of pattern recognition receptors that sense an array of exogenous structures and recent evidence shows they can also recognize defective endogenous molecules. The intracellular signaling cascades they set in motion lead to the expression of inflammatory mediators.
Synonyms:	related_synonym:	KEGG:04620; TLR signaling pathway

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Toll-like receptor signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		IEA	6	137,640,482	137,657,552	RGD:6907045	KEGG
G	Akt2	v-akt murine thymoma viral oncogene homolog 2		IEA	1	82,686,233	82,726,544	RGD:6907045	KEGG
G	Akt3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)		IEA	13	92,802,390	93,110,704	RGD:6907045	KEGG
G	Casp8	caspase 8		IEA	9	57,389,353	57,437,803	RGD:6907045	KEGG
G	Ccl3	chemokine (C-C motif) ligand 3		IEA	10	71,744,559	71,746,109	RGD:6907045	KEGG
G	Ccl5	chemokine (C-C motif) ligand 5		IEA	10	71,605,791	71,610,330	RGD:6907045	KEGG
G	Cd14	CD14 molecule		IEA	18	29,374,593	29,376,190	RGD:6907045	KEGG
G	Cd40	CD40 molecule, TNF receptor superfamily member 5		IEA	3	156,092,602	156,107,427	RGD:6907045	KEGG
G	Cd80	Cd80 molecule		IEA	11	64,045,358	64,070,072	RGD:6907045	KEGG
G	Cd86	CD86 molecule		IEA	11	66,215,233	66,238,882	RGD:6907045	KEGG
G	Chuk	conserved helix-loop-helix ubiquitous kinase		IEA	1	249,122,845	249,158,369	RGD:6907045	KEGG
G	Ctsk	cathepsin K		IEA	2	190,394,854	190,405,668	RGD:6907045	KEGG
G	Cxcl10	chemokine (C-X-C motif) ligand 10		IEA	14	17,265,986	17,268,183	RGD:6907045	KEGG
G	Cxcl11	chemokine (C-X-C motif) ligand 11		IEA	14	17,250,648	17,253,423	RGD:6907045	KEGG
G	Cxcl9	chemokine (C-X-C motif) ligand 9		IEA	14	17,284,085	17,288,996	RGD:6907045	KEGG
G	Fadd	Fas (TNFRSF6)-associated via death domain		IEA	1	205,010,363	205,012,768	RGD:6907045	KEGG
G	Fos	FBJ osteosarcoma oncogene		IEA	6	109,559,135	109,562,001	RGD:6907045	KEGG
G	Ifna1	interferon, alpha 1		IEA				RGD:6907045	KEGG
G	Ifna11	interferon alpha family, gene 11		IEA	5	108,150,128	108,150,703	RGD:6907045	KEGG
G	Ifna1l1	interferon-alpha 1-like 1		IEA	5	108,011,739	108,012,317	RGD:6907045	KEGG
G	Ifna2	interferon alpha family, gene 2		IEA	5	108,117,536	108,118,114	RGD:6907045	KEGG
G	Ifna4	interferon, alpha 4		IEA	5	107,886,554	107,887,123	RGD:6907045	KEGG
G	Ifnar1	interferon (alpha, beta and omega) receptor 1		IEA	11	31,454,789	31,478,449	RGD:6907045	KEGG
G	Ifnb1	interferon beta 1, fibroblast		IEA	5	107,837,628	107,838,182	RGD:6907045	KEGG
G	Ikbkb	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta		IEA	16	73,804,730	73,858,510	RGD:6907045	KEGG
G	Ikbke	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon		IEA	13	44,197,625	44,222,609	RGD:6907045	KEGG
G	Ikbkg	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma		IEA	X	160,386,558	160,420,190	RGD:6907045	KEGG
G	Il12a	interleukin 12A		IEA	2	158,710,261	158,717,689	RGD:6907045	KEGG
G	Il12b	interleukin 12B		IEA	10	29,558,955	29,568,331	RGD:6907045	KEGG
G	Il1b	interleukin 1 beta		IEA	3	116,964,422	116,970,867	RGD:6907045	KEGG
G	Il6	interleukin 6		IEA	4	456,799	461,376	RGD:6907045	KEGG
G	Irak1	interleukin-1 receptor-associated kinase 1		ISS	X	159,960,184	159,969,180	RGD:5685014	RGD
G	Irak1	interleukin-1 receptor-associated kinase 1		IEA	X	159,960,184	159,969,180	RGD:6907045	KEGG
G	Irak2	interleukin-1 receptor-associated kinase 2		ISS	4	149,543,029	149,599,463	RGD:5685014	RGD
G	Irak4	interleukin-1 receptor-associated kinase 4		ISS	7	133,055,185	133,081,614	RGD:5685014	RGD
G	Irak4	interleukin-1 receptor-associated kinase 4		IEA	7	133,055,185	133,081,614	RGD:6907045	KEGG
G	Irf3	interferon regulatory factor 3		ISS	1	95,470,284	95,475,078	RGD:5685014	RGD
G	Irf3	interferon regulatory factor 3		IEA	1	95,470,284	95,475,078	RGD:6907045	KEGG
G	Irf5	interferon regulatory factor 5		IEA	4	56,407,560	56,418,694	RGD:6907045	KEGG
G	Irf7	interferon regulatory factor 7		IEA	1	201,456,689	201,459,756	RGD:6907045	KEGG
G	Jun	jun proto-oncogene		IEA	5	115,358,166	115,361,259	RGD:6907045	KEGG
G	Lbp	lipopolysaccharide binding protein		IEA	3	149,016,605	149,043,530	RGD:6907045	KEGG
G	Ly96	lymphocyte antigen 96		ISS	5	1,701,969	1,705,247	RGD:5685019	RGD
G	Ly96	lymphocyte antigen 96		IEA	5	1,701,969	1,705,247	RGD:6907045	KEGG
G	Map2k1	mitogen activated protein kinase kinase 1		IEA	8	68,379,074	68,451,554	RGD:6907045	KEGG
G	Map2k2	mitogen activated protein kinase kinase 2		IEA	7	10,074,654	10,094,003	RGD:6907045	KEGG
G	Map2k3	mitogen activated protein kinase kinase 3		IEA	10	47,075,270	47,096,617	RGD:6907045	KEGG
G	Map2k4	mitogen activated protein kinase kinase 4		IEA	10	52,009,149	52,041,599	RGD:6907045	KEGG
G	Map2k6	mitogen-activated protein kinase kinase 6		IEA	10	99,859,684	99,974,446	RGD:6907045	KEGG
G	Map2k7	mitogen activated protein kinase kinase 7		IEA	12	1,545,407	1,552,353	RGD:6907045	KEGG
G	Map3k7	mitogen activated protein kinase kinase kinase 7		ISS	5	48,252,637	48,308,820	RGD:5685014	RGD
G	Map3k7	mitogen activated protein kinase kinase kinase 7		IEA	5	48,252,637	48,308,820	RGD:6907045	KEGG
G	Map3k8	mitogen-activated protein kinase kinase kinase 8		IEA	17	61,910,179	61,930,459	RGD:6907045	KEGG
G	Mapk1	mitogen activated protein kinase 1		IEA	11	85,968,732	86,030,387	RGD:6907045	KEGG
G	Mapk10	mitogen activated protein kinase 10		IEA	14	7,719,595	8,010,694	RGD:6907045	KEGG
G	Mapk11	mitogen-activated protein kinase 11		IEA	7	127,444,055	127,449,990	RGD:6907045	KEGG
G	Mapk12	mitogen-activated protein kinase 12		IEA	7	127,430,881	127,441,274	RGD:6907045	KEGG
G	Mapk13	mitogen activated protein kinase 13		IEA	20	7,055,313	7,064,405	RGD:6907045	KEGG
G	Mapk14	mitogen activated protein kinase 14		IEA	20	6,939,249	7,000,378	RGD:6907045	KEGG
G	Mapk3	mitogen activated protein kinase 3		IEA	1	185,935,044	185,941,245	RGD:6907045	KEGG
G	Mapk8	mitogen-activated protein kinase 8		IEA	16	8,925,133	9,004,897	RGD:6907045	KEGG
G	Mapk9	mitogen-activated protein kinase 9		IEA	10	35,353,486	35,384,319	RGD:6907045	KEGG
G	Myd88	myeloid differentiation primary response 88		ISS	8	124,299,729	124,303,798	RGD:5685014	RGD
G	Myd88	myeloid differentiation primary response 88		IEA	8	124,299,729	124,303,798	RGD:6907045	KEGG
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		IEA	2	233,091,013	233,187,501	RGD:6907045	KEGG
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		IEA	6	75,729,302	75,732,475	RGD:6907045	KEGG
G	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha		IEA	2	118,640,277	118,672,440	RGD:6907045	KEGG
G	Pik3cb	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta		IEA	8	103,886,682	103,957,112	RGD:6907045	KEGG
G	Pik3cd	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta		IEA	5	166,735,274	166,761,189	RGD:6907045	KEGG
G	Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)		IEA	2	32,602,673	32,675,350	RGD:6907045	KEGG
G	Pik3r2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)		IEA	16	19,171,101	19,179,650	RGD:6907045	KEGG
G	Pik3r3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)		IEA	5	136,497,494	136,566,473	RGD:6907045	KEGG
G	Pik3r5	phosphoinositide-3-kinase, regulatory subunit 5		IEA	10	55,227,872	55,248,301	RGD:6907045	KEGG
G	Rac1	ras-related C3 botulinum toxin substrate 1		IEA	12	11,380,314	11,400,531	RGD:6907045	KEGG
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		IEA	1	208,262,669	208,273,148	RGD:6907045	KEGG
G	RGD1559932	similar to interferon alpha 8/6 precursor; IFNa8/6 (B6)		IEA	5	108,328,742	108,329,296	RGD:6907045	KEGG
G	RGD1565911	similar to interferon alpha 8/6 precursor; IFNa8/6 (B6)		IEA	5	108,271,859	108,272,413	RGD:6907045	KEGG
G	Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1		ISS	17	37,183,591	37,216,533	RGD:5685014	RGD
G	Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1		IEA	17	37,183,591	37,216,533	RGD:6907045	KEGG
G	Spp1	secreted phosphoprotein 1		IEA				RGD:6907045	KEGG
G	Stat1	signal transducer and activator of transcription 1		IEA	9	46,455,635	46,497,560	RGD:6907045	KEGG
G	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1		ISS	7	118,368,997	118,402,928	RGD:5685016	RGD
G	Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2		ISS	1	2,568,536	2,617,742	RGD:5685016	RGD
G	Tbk1	TANK-binding kinase 1		ISS	7	60,863,099	60,896,131	RGD:5685014	RGD
G	Tbk1	TANK-binding kinase 1		IEA	7	60,863,099	60,896,131	RGD:6907045	KEGG
G	Ticam2	toll-like receptor adaptor molecule 2		ISS	18	40,776,776	40,793,784	RGD:5685014	RGD
G	Ticam2	toll-like receptor adaptor molecule 2		IEA	18	40,776,776	40,793,784	RGD:6907045	KEGG
G	Tirap	toll-interleukin 1 receptor (TIR) domain-containing adaptor protein		ISS	8	34,966,856	34,969,727	RGD:5685014	RGD
G	Tirap	toll-interleukin 1 receptor (TIR) domain-containing adaptor protein		IEA	8	34,966,856	34,969,727	RGD:6907045	KEGG
G	Tlr1	toll-like receptor 1		ISS	14	46,114,913	46,124,820	RGD:5685014	RGD
G	Tlr1	toll-like receptor 1		IDA	14	46,114,913	46,124,820	RGD:1643119	RGD
G	Tlr2	toll-like receptor 2		IMP	2	175,607,990	175,613,992	RGD:5684896	RGD
G	Tlr2	toll-like receptor 2		IDA	2	175,607,990	175,613,992	RGD:1643119	RGD
G	Tlr2	toll-like receptor 2		ISS	2	175,607,990	175,613,992	RGD:5685014	RGD
G	Tlr2	toll-like receptor 2		IEA	2	175,607,990	175,613,992	RGD:6907045	KEGG
G	Tlr3	toll-like receptor 3		IDA	16	50,112,910	50,126,371	RGD:1643119	RGD
G	Tlr3	toll-like receptor 3		ISS	16	50,112,910	50,126,371	RGD:5685014	RGD
G	Tlr3	toll-like receptor 3		IEA	16	50,112,910	50,126,371	RGD:6907045	KEGG
G	Tlr4	toll-like receptor 4		IDA	5	83,564,100	83,577,735	RGD:1643119	RGD
G	Tlr4	toll-like receptor 4		ISS	5	83,564,100	83,577,735	RGD:5685014	RGD
G	Tlr4	toll-like receptor 4		IEA	5	83,564,100	83,577,735	RGD:6907045	KEGG
G	Tlr5	toll-like receptor 5		IDA	13	99,025,501	99,029,755	RGD:1643119	RGD
G	Tlr5	toll-like receptor 5		ISS	13	99,025,501	99,029,755	RGD:5685014	RGD
G	Tlr5	toll-like receptor 5		IEA	13	99,025,501	99,029,755	RGD:6907045	KEGG
G	Tlr6	toll-like receptor 6		IMP	14	46,089,365	46,100,687	RGD:5684896	RGD
G	Tlr6	toll-like receptor 6		IDA	14	46,089,365	46,100,687	RGD:1643119	RGD
G	Tlr6	toll-like receptor 6		ISS	14	46,089,365	46,100,687	RGD:5685014	RGD
G	Tlr6	toll-like receptor 6		IEA	14	46,089,365	46,100,687	RGD:6907045	KEGG
G	Tlr7	toll-like receptor 7		ISS	X	47,330,737	47,356,841	RGD:5685014	RGD
G	Tlr7	toll-like receptor 7		IDA	X	47,330,737	47,356,841	RGD:1643119	RGD
G	Tlr7	toll-like receptor 7		IEA	X	47,330,737	47,356,841	RGD:6907045	KEGG
G	Tlr8	toll-like receptor 8		IDA				RGD:1643119	RGD
G	Tlr8	toll-like receptor 8		ISS				RGD:5685014	RGD
G	Tlr8	toll-like receptor 8		IEA				RGD:6907045	KEGG
G	Tlr9	toll-like receptor 9		ISS				RGD:5685014	RGD
G	Tlr9	toll-like receptor 9		IDA				RGD:1643119	RGD
G	Tlr9	toll-like receptor 9		IEA				RGD:6907045	KEGG
G	Tnf	tumor necrosis factor		IEA	20	3,661,000	3,663,618	RGD:6907045	KEGG
G	Tollip	toll interacting protein		IEA	1	202,008,799	202,029,669	RGD:6907045	KEGG
G	Tradd	TNFRSF1A-associated via death domain		ISS	19	35,073,150	35,075,251	RGD:5685014	RGD
G	Traf3	Tnf receptor-associated factor 3		ISS	6	135,925,375	136,027,270	RGD:5685014	RGD
G	Traf3	Tnf receptor-associated factor 3		IEA	6	135,925,375	136,027,270	RGD:6907045	KEGG
G	Traf6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase		ISS	3	86,827,582	86,847,408	RGD:5685014	RGD
G	Traf6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase		IEA	3	86,827,582	86,847,408	RGD:6907045	KEGG
G	Ube2n	ubiquitin-conjugating enzyme E2N		ISS	7	32,719,959	32,750,002	RGD:5685014	RGD
G	Ube2v1	ubiquitin-conjugating enzyme E2 variant 1		ISS	3	158,745,873	158,768,725	RGD:5685014	RGD
G	Unc93b1	unc-93 homolog B1 (C. elegans)		ISS	1	206,460,302	206,471,239	RGD:5685014	RGD

Term paths to the root

Path 1
Term	Annotations
Pathway Ontology	17154
signaling pathway	7601
signaling pathway pertinent to immunity	1872
signaling pathway in the innate immune response	235
pattern recognition receptor mediated pathway	235
Toll-like receptor signaling pathway	127
Path 2
Term	Annotations
Pathway Ontology	17154
regulatory pathway	5692
immune response pathway	950
innate immune response pathway	514
inflammatory response pathway	439
pattern recognition receptor mediated pathway	235
Toll-like receptor signaling pathway	127