ONTOLOGY REPORT - ANNOTATIONS

Term:statin pharmacodynamics pathway
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Accession:PW:0000728 term browser browse the term
Definition:The pathway of statins-target interaction and of the biochemical or physiological responses to them. Statins are a class of drugs used to lower cholesterol. They act as inhibitors of HMG-CoA reductase, the enzyme that catalyzes an early rate-limiting step in cholesterol biosynthesis. Genetic variations can cause differences in the response of the organism to the drug.
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statin pharmacodynamics pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase GBrowse link ISS 2 27,127,504 27,149,580 RGD:4892116 RGD
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Path 1
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  Pathway Ontology 17140
    drug pathway 19
      cardiovascular system drug pathway 5
        statin drug pathway 2
          statin pharmacodynamics pathway 1
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