PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: FasL mediated signaling pathway
Accession: PW:0000681
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Definition: Fas ligand binding to its receptor triggers a conformational change that allows the receptor to assemble a signaling complex known as DISC, followed by recruitment of pro-caspase-8 and activation of caspase-3 and -7. It is believed that Fas-mediated signaling to elicit apoptosis follows two routes.
Synonyms: related_synonym: Fas signaling pathway; FasL/ CD95L signaling
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Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200080
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bid
BH3 interacting domain death agonist
IEP ISO
PID RGD
PMID:18090083 PMID:19239902
PID:200080, RGD:2314002 , RGD:4143196
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Birc2
baculoviral IAP repeat-containing 2
ISO
PID
PID:200080
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Birc3
baculoviral IAP repeat-containing 3
ISO
PID
PID:200080
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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Btk
Bruton tyrosine kinase
ISO
PID
PID:200080
NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853
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Casp3
caspase 3
ISO
PID RGD
PMID:19239902
PID:200080, RGD:4143196
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
ISO
RGD
PMID:19239902
RGD:4143196
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
IMP ISO
PID RGD
PMID:18090083 PMID:19239902
PID:200080, RGD:2314002 , RGD:4143196
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Cflar
CASP8 and FADD-like apoptosis regulator
ISO IEP
PID RGD
PMID:19239902 PMID:19107989
PID:200080, RGD:4143196 , RGD:8662854
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
ISO
PID
PID:200080
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Cltc
clathrin heavy chain
ISO
PID
PID:200080
NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
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Ezr
ezrin
ISO
PID
PID:200080
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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Fadd
Fas associated via death domain
ISO
PID RGD
PMID:19239902
PID:200080, RGD:4143196
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Faim2
Fas apoptotic inhibitory molecule 2
ISO
PID
PID:200080
NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
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Fas
Fas cell surface death receptor
IEP ISO
PID RGD
PMID:18090083 PMID:19239902 PMID:19107989
PID:200080, RGD:2314002 , RGD:4143196 , RGD:8662854
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
IEP ISO
PID RGD
PMID:18090083 PMID:19239902
PID:200080, RGD:2314002 , RGD:4143196
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
PID
PID:200080
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISO
PID
PID:200080
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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Map2k6
mitogen-activated protein kinase kinase 6
ISO
PID
PID:200080
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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Map2k7
mitogen activated protein kinase kinase 7
ISO
PID
PID:200080
NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
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Map3k1
mitogen-activated protein kinase kinase kinase 1
ISO
PID
PID:200080
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Mapk10
mitogen activated protein kinase 10
ISO
PID
PID:200080
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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Mapk11
mitogen-activated protein kinase 11
ISO
PID
PID:200080
NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
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Mapk14
mitogen activated protein kinase 14
ISO
PID
PID:200080
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk8
mitogen-activated protein kinase 8
ISO
PID
PID:200080
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
ISO
PID
PID:200080
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Pdpk1
3-phosphoinositide dependent protein kinase-1
ISO
PID
PID:200080
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
PID
PID:200080
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
ISO
PID
PID:200080
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
ISO
PID
PID:200080
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
PID
PID:200080
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
ISO
PID
PID:200080
NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
ISO
PID
PID:200080
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
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Rfc1
replication factor C subunit 1
ISO
PID
PID:200080
NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
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Ripk1
receptor interacting serine/threonine kinase 1
ISO
PID
PID:200080
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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Smpd1
sphingomyelin phosphodiesterase 1
ISO
PID
PID:200080
NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
ISO
PID
PID:200080
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Syk
spleen associated tyrosine kinase
ISO
PID
PID:200080
NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
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