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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:insulin secretion pathway
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Accession:PW:0000674 term browser browse the term
Definition:Insulin secretion by pancreatic beta-cells is an important aspect of glucose homeostasis. A major component of glucose-stimulated insulin secretion is represented by the route dependent on the ATP-sensitive potassium channels. However, other contributions are also likely to promote insulin secretion.
Synonyms:related_synonym: Regulation of insulin secretion;   insulin secretion
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insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 TAS RGD PMID:18940941 RGD:2311063 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A TAS RGD PMID:16868246 RGD:2311105 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C TAS RGD PMID:16868246 RGD:2311105 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D TAS RGD PMID:16868246 RGD:2311105 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:19295123 RGD:2311087 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Gck glucokinase TAS RGD PMID:18774732 RGD:2311061 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 TAS RGD PMID:12830383 RGD:2311121 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 TAS RGD PMID:18940941 RGD:2311063 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family ISO RGD PMID:19295123 RGD:2311087 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family ISO RGD PMID:19295123 RGD:2311087 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 TAS RGD PMID:18774732 RGD:2311061 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Snap25 synaptosome associated protein 25 TAS RGD PMID:12830383 RGD:2311121 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Stx1a syntaxin 1A ISO RGD PMID:19295123 RGD:2311087 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO RGD PMID:19295123 RGD:2311087 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Syt7 synaptotagmin 7 TAS
IMP		 RGD PMID:18713958 PMID:17709608 RGD:2311148, RGD:2311143 NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026 		JBrowse link
G Syt7_v1 synaptotagmin 7, variant 1 IMP RGD PMID:17709608 RGD:2311143
G Syt9 synaptotagmin 9 TAS
IMP		 RGD PMID:18713958 PMID:16165130 RGD:2311148, RGD:2311147 NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007 		JBrowse link
G Unc13a unc-13 homolog A ISO RGD PMID:19295123 RGD:2311087 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 ISO RGD PMID:19295123 RGD:2311087 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
altered insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO DNA:missense mutation::A1369S (human) RGD PMID:17259403 RGD:2313628 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 ISO polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:missense mutation::p.E23K (human)		 RGD PMID:15565284 PMID:17259403 RGD:2313610, RGD:2313628 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        glucose homeostasis pathway 344
          insulin secretion pathway 19
            altered insulin secretion pathway 2
paths to the root