ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:related_synonym: Il-6 signaling pathway;   PID:200146
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interleukin-6 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G A2m alpha-2-macroglobulin GBrowse link ISO 6 121,586,191 121,629,256 RGD:6484113 PID
G Adam10 a disintegrin and metallopeptidase domain 10 GBrowse link ISS 9 70,526,808 70,628,036 RGD:5686846 RGD
G Adam17 a disintegrin and metallopeptidase domain 17 GBrowse link ISS 12 21,329,370 21,379,452 RGD:5686834 RGD
G Adam17 a disintegrin and metallopeptidase domain 17 GBrowse link ISS 12 21,329,370 21,379,452 RGD:5686846 RGD
G Akt1 thymoma viral proto-oncogene 1 GBrowse link ISO 12 113,892,032 113,912,487 RGD:6484113 PID
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta GBrowse link ISO 2 167,514,415 167,515,918 RGD:6484113 PID
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta GBrowse link ISO 16 15,887,379 15,889,638 RGD:6484113 PID
G Crp C-reactive protein, pentraxin-related GBrowse link ISO 1 174,628,187 174,630,097 RGD:6484113 PID
G Fgg fibrinogen gamma chain GBrowse link ISO 3 82,811,818 82,818,971 RGD:6484113 PID
G Fos FBJ osteosarcoma oncogene GBrowse link ISO 12 86,814,851 86,818,219 RGD:6484113 PID
G Foxo1 forkhead box O1 GBrowse link ISO 3 52,072,259 52,154,031 RGD:6484113 PID
G Gab1 growth factor receptor bound protein 2-associated protein 1 GBrowse link ISO 8 83,288,333 83,404,378 RGD:6484113 PID
G Gab2 growth factor receptor bound protein 2-associated protein 2 GBrowse link ISO 7 104,230,261 104,457,461 RGD:6484113 PID
G Grb2 growth factor receptor bound protein 2 GBrowse link ISS 11 115,505,444 115,569,911 RGD:5686834 RGD
G Grb2 growth factor receptor bound protein 2 GBrowse link ISO 11 115,505,444 115,569,911 RGD:6484113 PID
G Hck hemopoietic cell kinase GBrowse link ISO 2 152,934,204 152,977,177 RGD:6484113 PID
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 GBrowse link ISO 10 86,153,586 86,168,189 RGD:6484113 PID
G Il6 interleukin 6 GBrowse link ISS 5 30,339,701 30,346,508 RGD:5686834 RGD
G Il6 interleukin 6 GBrowse link ISS 5 30,339,701 30,346,508 RGD:1580493 RGD
G Il6 interleukin 6 GBrowse link ISS 5 30,339,701 30,346,508 RGD:5686839 RGD
G Il6 interleukin 6 GBrowse link ISO 5 30,339,701 30,346,508 RGD:6484113 PID
G Il6ra interleukin 6 receptor, alpha GBrowse link ISS 3 89,673,246 89,717,084 RGD:5686839 RGD
G Il6ra interleukin 6 receptor, alpha GBrowse link ISS 3 89,673,246 89,717,084 RGD:5686834 RGD
G Il6ra interleukin 6 receptor, alpha GBrowse link ISO 3 89,673,246 89,717,084 RGD:6484113 PID
G Il6st interleukin 6 signal transducer GBrowse link ISS 13 113,254,278 113,297,068 RGD:5686834 RGD
G Il6st interleukin 6 signal transducer GBrowse link ISS 13 113,254,278 113,297,068 RGD:5686839 RGD
G Il6st interleukin 6 signal transducer GBrowse link ISS 13 113,254,278 113,297,068 RGD:5686900 RGD
G Il6st interleukin 6 signal transducer GBrowse link ISO 13 113,254,278 113,297,068 RGD:6484113 PID
G Irf1 interferon regulatory factor 1 GBrowse link ISO 11 53,583,516 53,591,876 RGD:6484113 PID
G Jak1 Janus kinase 1 GBrowse link ISS 4 100,824,579 100,937,887 RGD:5686839 RGD
G Jak1 Janus kinase 1 GBrowse link ISO 4 100,824,579 100,937,887 RGD:6484113 PID
G Jak2 Janus kinase 2 GBrowse link ISS 19 29,326,318 29,387,570 RGD:5686839 RGD
G Jak2 Janus kinase 2 GBrowse link ISO 19 29,326,318 29,387,570 RGD:6484113 PID
G Jun Jun oncogene GBrowse link ISO 4 94,715,727 94,718,913 RGD:6484113 PID
G Junb Jun-B oncogene GBrowse link ISO 8 87,500,811 87,502,617 RGD:6484113 PID
G Lbp lipopolysaccharide binding protein GBrowse link ISO 2 158,132,229 158,158,588 RGD:6484113 PID
G Lmo4 LIM domain only 4 GBrowse link ISO 3 143,851,494 143,868,219 RGD:6484113 PID
G Map2k4 mitogen-activated protein kinase kinase 4 GBrowse link ISO 11 65,501,746 65,601,799 RGD:6484113 PID
G Map2k6 mitogen-activated protein kinase kinase 6 GBrowse link ISO 11 110,260,436 110,374,951 RGD:6484113 PID
G Mapk11 mitogen-activated protein kinase 11 GBrowse link ISO 15 88,972,912 88,980,036 RGD:6484113 PID
G Mapk14 mitogen-activated protein kinase 14 GBrowse link ISO 17 28,828,287 28,885,350 RGD:6484113 PID
G Mcl1 myeloid cell leukemia sequence 1 GBrowse link ISO 3 95,462,643 95,467,102 RGD:6484113 PID
G Mitf microphthalmia-associated transcription factor GBrowse link ISO 6 97,757,052 97,971,352 RGD:6484113 PID
G Myc myelocytomatosis oncogene GBrowse link ISO 15 61,816,896 61,821,916 RGD:6484113 PID
G Pias1 protein inhibitor of activated STAT 1 GBrowse link ISO 9 62,727,884 62,828,686 RGD:6484113 PID
G Pias3 protein inhibitor of activated STAT 3 GBrowse link ISO 3 96,500,298 96,509,993 RGD:6484113 PID
G Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide GBrowse link ISO 3 32,335,073 32,367,408 RGD:6484113 PID
G Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) GBrowse link ISO 13 102,450,716 102,538,172 RGD:6484113 PID
G Prkcd protein kinase C, delta GBrowse link ISO 14 31,408,555 31,423,498 RGD:6484113 PID
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 GBrowse link ISS 5 121,580,542 121,641,406 RGD:5686834 RGD
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 GBrowse link ISO 5 121,580,542 121,641,406 RGD:6484113 PID
G Rac1 RAS-related C3 botulinum substrate 1 GBrowse link ISO 5 144,266,349 144,288,861 RGD:6484113 PID
G Socs3 suppressor of cytokine signaling 3 GBrowse link ISO 11 117,827,393 117,830,680 RGD:6484113 PID
G Sos1 son of sevenless homolog 1 (Drosophila) GBrowse link ISS 17 80,793,092 80,879,793 RGD:5686834 RGD
G Sos1 son of sevenless homolog 1 (Drosophila) GBrowse link ISO 17 80,793,092 80,879,793 RGD:6484113 PID
G Sos2 son of sevenless homolog 2 (Drosophila) GBrowse link ISS 12 70,684,748 70,782,839 RGD:5686834 RGD
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISS 1 52,176,282 52,218,707 RGD:5686834 RGD
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISS 1 52,176,282 52,218,707 RGD:5686839 RGD
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISO 1 52,176,282 52,218,707 RGD:6484113 PID
G Stat3 signal transducer and activator of transcription 3 GBrowse link ISS 11 100,748,124 100,800,825 RGD:5686839 RGD
G Stat3 signal transducer and activator of transcription 3 GBrowse link ISS 11 100,748,124 100,800,825 RGD:5686834 RGD
G Stat3 signal transducer and activator of transcription 3 GBrowse link ISO 11 100,748,124 100,800,825 RGD:6484113 PID
G Timp1 tissue inhibitor of metalloproteinase 1 GBrowse link ISO X 20,447,292 20,451,863 RGD:6484113 PID
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 GBrowse link ISO 14 78,677,253 78,707,850 RGD:6484113 PID
G Tyk2 tyrosine kinase 2 GBrowse link ISS 9 20,908,512 20,935,719 RGD:5686839 RGD
G Tyk2 tyrosine kinase 2 GBrowse link ISO 9 20,908,512 20,935,719 RGD:6484113 PID
G Vav1 vav 1 oncogene GBrowse link ISO 17 57,418,523 57,468,659 RGD:6484113 PID
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  Pathway Ontology 15658
    signaling pathway 6604
      cytokine and chemokine mediated signaling pathway 688
        cytokine mediated signaling pathway 687
          Interleukin mediated signaling pathway 461
            interleukin-6 family mediated signaling pathway 67
              interleukin-6 signaling pathway 67
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