endothelin signaling pathway - Ontology Report

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Term:	endothelin signaling pathway	go back to main search page
Accession:	PW:0000506	browse the term
Definition:	Endothelins represent a family of three vasoconstrictor peptides that play a role in several intracellular signaling pathways and have been associated with hypertension, heart failure and myocardial infarction.
Synonyms:	related_synonym:	PID:200005

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endothelin signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	ADCY1	adenylate cyclase 1 (brain)		EXP	7	45,614,125	45,762,715	RGD:6484113	PID
G	ADCY2	adenylate cyclase 2 (brain)		EXP	5	7,396,343	7,830,194	RGD:6484113	PID
G	ADCY3	adenylate cyclase 3		EXP	2	25,042,038	25,142,055	RGD:6484113	PID
G	ADCY4	adenylate cyclase 4		EXP	14	24,787,555	24,804,277	RGD:6484113	PID
G	ADCY5	adenylate cyclase 5		EXP	3	123,001,143	123,167,392	RGD:6484113	PID
G	ADCY6	adenylate cyclase 6		EXP	12	49,159,975	49,182,820	RGD:6484113	PID
G	ADCY7	adenylate cyclase 7		EXP	16	50,321,823	50,352,043	RGD:6484113	PID
G	ADCY8	adenylate cyclase 8 (brain)		EXP	8	131,792,547	132,052,835	RGD:6484113	PID
G	ADCY9	adenylate cyclase 9		EXP	16	4,012,650	4,166,186	RGD:6484113	PID
G	AKT1	v-akt murine thymoma viral oncogene homolog 1		EXP	14	105,235,686	105,262,080	RGD:6484113	PID
G	BCAR1	breast cancer anti-estrogen resistance 1		EXP	16	75,262,928	75,301,951	RGD:6484113	PID
G	CDC42	cell division cycle 42		EXP	1	22,379,120	22,419,436	RGD:6484113	PID
G	COL1A2	collagen, type I, alpha 2		EXP	7	94,023,873	94,060,544	RGD:6484113	PID
G	COL3A1	collagen, type III, alpha 1		EXP	2	189,839,099	189,877,472	RGD:6484113	PID
G	CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)		EXP	17	1,324,647	1,359,561	RGD:6484113	PID
G	CYSLTR1	cysteinyl leukotriene receptor 1		EXP	X	77,528,130	77,583,087	RGD:6484113	PID
G	CYSLTR2	cysteinyl leukotriene receptor 2		EXP	13	49,280,951	49,283,498	RGD:6484113	PID
G	ECE1	endothelin converting enzyme 1		ISS	1	21,543,740	21,672,034	RGD:1581735	RGD
G	EDN1	endothelin 1		TAS	6	12,290,529	12,297,427	RGD:1580323	RGD
G	EDN1	endothelin 1		EXP	6	12,290,529	12,297,427	RGD:6484113	PID
G	EDN2	endothelin 2		EXP	1	41,944,446	41,950,344	RGD:6484113	PID
G	EDN3	endothelin 3		EXP	20	57,875,499	57,901,047	RGD:6484113	PID
G	EDNRA	endothelin receptor type A		ISS	4	148,402,069	148,466,106	RGD:4892591	RGD
G	EDNRA	endothelin receptor type A		EXP	4	148,402,069	148,466,106	RGD:6484113	PID
G	EDNRB	endothelin receptor type B		ISS	13 13	78,469,616 78,513,393	78,549,664 78,549,674	RGD:4892591	RGD
G	EDNRB	endothelin receptor type B		EXP	13 13	78,469,616 78,513,393	78,549,664 78,549,674	RGD:6484113	PID
G	FOS	FBJ murine osteosarcoma viral oncogene homolog		EXP	14	75,745,481	75,748,937	RGD:6484113	PID
G	GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)		EXP	19	3,094,408	3,121,468	RGD:6484113	PID
G	GNA12	guanine nucleotide binding protein (G protein) alpha 12		EXP	7	2,767,739	2,883,959	RGD:6484113	PID
G	GNA14	guanine nucleotide binding protein (G protein), alpha 14		EXP	9	80,037,995	80,263,232	RGD:6484113	PID
G	GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)		EXP	19	3,136,191	3,163,766	RGD:6484113	PID
G	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1		EXP	7	79,764,140	79,848,725	RGD:6484113	PID
G	GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2		EXP	3	50,273,647	50,296,786	RGD:6484113	PID
G	GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3		EXP	1	110,091,186	110,138,465	RGD:6484113	PID
G	GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type		EXP	18	11,689,014	11,885,684	RGD:6484113	PID
G	GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O		EXP	16	56,225,251	56,391,356	RGD:6484113	PID
G	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide		EXP	9	80,335,189	80,646,219	RGD:6484113	PID
G	GNAZ	guanine nucleotide binding protein (G protein), alpha z polypeptide		EXP	22	23,412,669	23,467,221	RGD:6484113	PID
G	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog		EXP	11	532,242	535,550	RGD:6484113	PID
G	JAK2	Janus kinase 2		EXP	9	4,985,245	5,128,183	RGD:6484113	PID
G	JUN	jun proto-oncogene		EXP	1	59,246,463	59,249,785	RGD:6484113	PID
G	MAP2K1	mitogen-activated protein kinase kinase 1		EXP	15	66,679,211	66,783,882	RGD:6484113	PID
G	MAP2K2	mitogen-activated protein kinase kinase 2		EXP	19	4,090,319	4,124,126	RGD:6484113	PID
G	MAPK1	mitogen-activated protein kinase 1		EXP	22	22,113,946	22,221,970	RGD:6484113	PID
G	MAPK14	mitogen-activated protein kinase 14		EXP	6	35,995,454	36,079,013	RGD:6484113	PID
G	MAPK3	mitogen-activated protein kinase 3		EXP	16	30,125,426	30,134,630	RGD:6484113	PID
G	MAPK8	mitogen-activated protein kinase 8		EXP	10	49,609,687	49,643,183	RGD:6484113	PID
G	MMP1	matrix metallopeptidase 1 (interstitial collagenase)		EXP	11	102,660,641	102,668,966	RGD:6484113	PID
G	NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3		ISS	16	68,119,269	68,263,162	RGD:1581961	RGD
G	NOS2	nitric oxide synthase 2, inducible		ISS	17	26,083,792	26,127,555	RGD:1582119	RGD
G	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)		EXP	1	186,798,032	186,958,113	RGD:6484113	PID
G	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)		EXP	20	8,113,296	8,865,547	RGD:6484113	PID
G	PLCB2	phospholipase C, beta 2		EXP	15	40,580,098	40,600,174	RGD:6484113	PID
G	PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)		EXP	11	64,018,995	64,036,924	RGD:6484113	PID
G	PRKCA	protein kinase C, alpha		EXP	17	64,298,926	64,806,862	RGD:6484113	PID
G	PRKCD	protein kinase C, delta		EXP	3	53,195,223	53,226,733	RGD:6484113	PID
G	PRKCE	protein kinase C, epsilon		EXP	2	45,879,043	46,415,129	RGD:6484113	PID
G	PRKCG	protein kinase C, gamma		EXP	19	54,385,467	54,410,901	RGD:6484113	PID
G	PRKCH	protein kinase C, eta		EXP	14	61,788,515	62,017,698	RGD:6484113	PID
G	PRKCQ	protein kinase C, theta		EXP	10	6,469,105	6,622,254	RGD:6484113	PID
G	PTK2B	protein tyrosine kinase 2 beta		EXP	8	27,168,999	27,316,908	RGD:6484113	PID
G	RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)		EXP	7	6,414,126	6,443,598	RGD:6484113	PID
G	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1		EXP	3	12,625,100	12,705,700	RGD:6484113	PID
G	RHOA	ras homolog family member A		EXP	3	49,396,578	49,449,526	RGD:6484113	PID
G	SLC9A1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1		EXP	1	27,425,300	27,481,621	RGD:6484113	PID
G	SLC9A3	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3		EXP	5	473,334	524,549	RGD:6484113	PID
G	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)		EXP	20	35,973,088	36,033,821	RGD:6484113	PID
G	TRPC6	transient receptor potential cation channel, subfamily C, member 6		EXP	11	101,322,295	101,454,659	RGD:6484113	PID

Term paths to the root

Path 1
Term	Annotations
Pathway Ontology	15791
signaling pathway	6748
hormone signaling pathway	1024
peptide and protein hormone signaling pathway	829
endothelin signaling pathway	68