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Term:proteasome degradation pathway involving cullin-dependent ubiquitin ligases
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Accession:PW:0000415 term browser browse the term
Definition:A proteasome degradation pathway mediated by cullins. Cullins are components of E3 ligase complexes and substrates for Nedd8 - a ubiquitin-like molecule. Neddylation is thought to modulate the activity of cullins.

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proteasome degradation pathway involving cullin-dependent ubiquitin ligases term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cul1 cullin 1 GBrowse link ISS 4 75,636,914 75,705,724 RGD:1559274 RGD
G Cul2 cullin 2 GBrowse link ISS 17 62,701,289 62,741,344 RGD:1559275 RGD
G Cul3 cullin 3 GBrowse link ISS 9 79,574,062 79,634,396 RGD:1559279 RGD
G Cul5 cullin 5 GBrowse link TAS 8 57,080,787 57,132,486 RGD:1299331 RGD
G Cul7 cullin 7 GBrowse link ISS 9 10,020,543 10,034,167 RGD:1559286 RGD
G Nae1 NEDD8 activating enzyme E1 subunit 1 GBrowse link ISS 19 382,556 408,667 RGD:634557 RGD
G Nedd8 neural precursor cell expressed, developmentally down-regulated 8 GBrowse link ISS 15 33,797,457 33,820,624 RGD:1549457 RGD
G Rbx1 ring-box 1, E3 ubiquitin protein ligase GBrowse link ISS 7 119,794,976 119,805,104 RGD:1559277 RGD
G Uba3 ubiquitin-like modifier activating enzyme 3 GBrowse link TAS 4 131,902,438 131,924,610 RGD:634396 RGD
G Ube2m ubiquitin-conjugating enzyme E2M GBrowse link ISS 1 72,885,667 72,889,204 RGD:1559272 RGD
G Vhl von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link ISS 4 149,529,396 149,536,289 RGD:1559297 RGD
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  Pathway Ontology 17154
    regulatory pathway 5692
      pathway pertinent to protein folding, sorting, modification, translocation and degradation 375
        protein degradation pathway 359
          ubiquitin, ubiquitin-like/proteasome degradation pathway 202
            ubiquitin/proteasome degradation pathway 202
              proteasome degradation pathway involving cullin-dependent ubiquitin ligases 11
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