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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:phase I biotransformation pathway via cytochrome P450
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Accession:PW:0000375 term browser browse the term
Definition:The major phase I biotransformation pathway for the activation of endogenous and exogenous substances carried out by members of the cytochrome P450 superfamily.
Synonyms:related_synonym: KEGG:00980;   KEGG:00982


show annotations for term's descendants           Sort by:
phase I biotransformation pathway via cytochrome P450 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 IEA KEGG rno:00980 rno:00982 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 IEA KEGG rno:00980 rno:00982 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921 		JBrowse link
G Aox1 aldehyde oxidase 1 IEA KEGG rno:00982 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Aox2 aldehyde oxidase 2 IEA KEGG rno:00982 NCBI chr 9:59,828,403...59,916,175
Ensembl chr 9:59,828,084...59,916,146 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA
IEA		 KEGG
RGD		 PMID:12464257 rno:00980, RGD:727674 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 IDA
IEA		 KEGG
RGD		 PMID:6772643 rno:00980 rno:00982, RGD:151347456 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 IEP
IEA		 KEGG
RGD		 PMID:7744798 rno:00980, RGD:728267 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 IEP
IEA		 KEGG
RGD		 PMID:3818621 rno:00982, RGD:70704 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 NAS
IEA		 KEGG
RGD		 PMID:10879814 rno:00982, RGD:1357962 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 IDA
IEA		 KEGG
RGD		 PMID:12167220 rno:00982, RGD:1298847 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00980 rno:00982, RGD:1300401 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 IEA KEGG rno:00980 rno:00982 NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 NAS
IEA		 KEGG
RGD		 PMID:10879814 rno:00980 rno:00982, RGD:1357962 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 IEA KEGG rno:00980 rno:00982 NCBI chr 1:81,886,097...81,915,066
Ensembl chr 1:81,886,098...81,915,066 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 IEA KEGG rno:00980 rno:00982 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 NAS
IEA		 KEGG
RGD		 PMID:10879814 rno:00980 rno:00982, RGD:1357962 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 IEA KEGG rno:00980 rno:00982 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 IEA KEGG rno:00980 rno:00982 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191 		JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 IEA KEGG rno:00980 rno:00982 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738 		JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 IEA KEGG rno:00980 rno:00982 NCBI chr 1:242,889,218...242,913,869
Ensembl chr 1:242,889,224...242,913,858 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 IEA KEGG rno:00980 rno:00982 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709 		JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209 		JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 IEA KEGG rno:00982 NCBI chr 7:113,899,905...113,904,458
Ensembl chr 7:113,899,890...113,904,495 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 IEA KEGG rno:00980 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 IEA KEGG rno:00980 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 IEA KEGG rno:00980 rno:00982 NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 IEA KEGG rno:00980 rno:00982 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 IEA KEGG rno:00980 rno:00982 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 IEA KEGG rno:00980 rno:00982 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 IDA
IMP		 RGD PMID:8248926 PMID:9310344 RGD:1626415, RGD:1626420 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Dhdh dihydrodiol dehydrogenase IEA KEGG rno:00980 NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197 		JBrowse link
G Ephx1 epoxide hydrolase 1 IEA KEGG rno:00980 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 IEA KEGG rno:00982 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 IEA KEGG rno:00982 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 IEA KEGG rno:00982 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 IEA KEGG rno:00982 NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 IEA KEGG rno:00982 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 IEA KEGG rno:00980 rno:00982 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 IEA KEGG rno:00980 rno:00982 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta3l1 glutathione S-transferase alpha 3 like 1 IEA KEGG rno:00980 rno:00982 NCBI chr 9:23,619,691...23,628,517
Ensembl chr 9:23,620,010...23,632,333 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 IEA KEGG rno:00980 rno:00982 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 IEA KEGG rno:00980 rno:00982 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 IEA KEGG rno:00980 rno:00982 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm3 glutathione S-transferase mu 3 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstm6 glutathione S-transferase, mu 6 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,579,566...195,584,340
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 IEA KEGG rno:00980 rno:00982 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 IEA KEGG rno:00980 rno:00982 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 IEA KEGG rno:00980 rno:00982 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 IEA KEGG rno:00980 rno:00982 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Maoa monoamine oxidase A IEA KEGG rno:00982 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B IEA KEGG rno:00982 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 IEA KEGG rno:00980 rno:00982 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 IEA KEGG rno:00980 rno:00982 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 IEA KEGG rno:00980 rno:00982 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 IEA KEGG rno:00980 rno:00982 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 IEA KEGG rno:00980 rno:00982 NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B IEA KEGG rno:00980 rno:00982 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 IEA KEGG rno:00980 rno:00982 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 IEA KEGG rno:00980 rno:00982 NCBI chr14:20,817,285...20,833,917
Ensembl chr14:20,817,285...20,833,917 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      xenobiotic metabolic pathway 135
        phase I biotransformation pathway 83
          phase I biotransformation pathway via cytochrome P450 83
paths to the root