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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hypoxia inducible factor pathway
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Accession:PW:0000360 term browser browse the term
Definition:The hypoxia inducible transcription factor is activated in response to hypoxic conditions to promote the expression of many genes that play important roles in glucose and energy metabolism, angiogenesis and erythropoiesis.
Synonyms:related_synonym: HIF pathway;   Regulation of gene expression by Hypoxia-inducible Factor
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show annotations for term's descendants           Sort by:
hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO PID PID:200202 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO PID PID:200036 PID:200202 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adm adrenomedullin ISO PID PID:200202 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adora2a adenosine A2a receptor ISO PID PID:200036 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200202 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A ISO PID PID:200202 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Aldoart2 aldolase 1 A retrogene 2 ISO PID PID:200202 NCBI chr 6:72,939,821...72,941,511
Ensembl chr 6:72,939,788...72,941,709 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO PID PID:200036 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO PID
RGD		 PMID:22169972 PID:200036 PID:200202, RGD:6483352 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 ISO RGD PMID:22169972 RGD:6483352 NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 ISO PID PID:200036 PID:200202 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 ISO PID PID:200202 NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468 		JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO PID PID:200202 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Car9 carbonic anhydrase 9 ISO PID PID:200202 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 ISO PID PID:200036 PID:200202 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Cops5 COP9 signalosome subunit 5 ISO PID PID:200202 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Cp ceruloplasmin ISO PID PID:200202 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO PID PID:200202 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crebbp CREB binding protein ISO PID
RGD		 PMID:19364912 PMID:20396958 PID:200036 PID:200202, RGD:6483358, RGD:6483503 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cul2 cullin 2 ISO RGD PMID:19364912 RGD:6483358 NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO PID PID:200202 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO PID PID:200202 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Edn1 endothelin 1 ISO PID PID:200202 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Efna1 ephrin A1 ISO PID PID:200036 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IDA
ISO
TAS		 PID
RGD		 PMID:12876291 PMID:20396958 PMID:19364912 PMID:14597660 PID:200036 PID:200202, RGD:727754, RGD:6483503, RGD:6483358, RGD:1334466 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 ISO PID
RGD		 PMID:20396958 PID:200036, RGD:6483503 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 ISO PID
RGD		 PMID:20396958 PID:200036 PID:200202, RGD:6483503 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E ISO PID PID:200036 NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096 		JBrowse link
G Elk1 ETS transcription factor ELK1 ISO PID PID:200036 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Elob elongin B ISO PID
RGD		 PMID:19364912 PID:200036, RGD:6483358 NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635 		JBrowse link
G Eloc elongin C ISO PID
RGD		 PMID:19364912 PID:200036, RGD:6483358 NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890 		JBrowse link
G Eng endoglin ISO PID PID:200202 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Eno1 enolase 1 ISO PID PID:200202 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Ep300 E1A binding protein p300 ISO PID
RGD		 PMID:19364912 PMID:20396958 PID:200036 PID:200202, RGD:6483358, RGD:6483503 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO PID
RGD		 PMID:22169972 PMID:20396958 PID:200036, RGD:6483352, RGD:6483503 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Epo erythropoietin ISO PID PID:200036 PID:200202 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor ISO PID PID:200036 PID:200202 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Fech ferrochelatase ISO PID PID:200202 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO PID PID:200036 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200202 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO PID PID:200202 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Fxn frataxin ISO PID PID:200036 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Gata2 GATA binding protein 2 ISO PID PID:200202 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Gck glucokinase ISO PID PID:200202 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Hdac7 histone deacetylase 7 ISO PID PID:200202 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IDA
ISO		 PID
RGD		 PMID:12388599 PMID:20396958 PMID:22169972 PMID:18614764 PMID:15063765 PID:200202, RGD:628389, RGD:6483503, RGD:6483352, RGD:2301848, RGD:1580561 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor ISO PID
RGD		 PMID:14597660 PMID:19364912 PMID:22169972 PID:200036, RGD:1334466, RGD:6483358, RGD:6483352 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha TAS
ISO		 RGD PMID:11237857 PMID:22169972 RGD:68201, RGD:6483352 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758 		JBrowse link
G Hk1 hexokinase 1 ISO PID PID:200202 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hk2 hexokinase 2 ISO PID PID:200202 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmox1 heme oxygenase 1 ISO PID PID:200202 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha ISO PID PID:200202 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Id2 inhibitor of DNA binding 2 ISO PID PID:200202 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 ISO PID PID:200202 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO PID PID:200202 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200202 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor ISO PID PID:200036 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Ldha lactate dehydrogenase A ISO PID PID:200202 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lep leptin ISO PID PID:200202 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO PID PID:200202 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO PID PID:200036 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 ISO PID PID:200202 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO PID PID:200202 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO PID PID:200202 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO PID PID:200202 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npm1 nucleophosmin 1 ISO PID PID:200202 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Nt5e 5' nucleotidase, ecto ISO PID PID:200202 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin ISO RGD PMID:19364912 RGD:6483358 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO PID PID:200202 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pfkl phosphofructokinase, liver type ISO PID PID:200202 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO PID PID:200036 PID:200202 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pgm1 phosphoglucomutase 1 ISO PID PID:200202 NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728 		JBrowse link
G Pkm pyruvate kinase M1/2 ISO PID PID:200202 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Plin2 perilipin 2 ISO PID PID:200202 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO PID PID:200036 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 ISO RGD PMID:19364912 RGD:6483358 NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224 		JBrowse link
G Serpine1 serpin family E member 1 ISO PID PID:200036 PID:200202 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sirt1 sirtuin 1 ISO PID PID:200036 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 ISO PID PID:200036 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO PID PID:200036 PID:200202 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Smad3 SMAD family member 3 ISO PID PID:200202 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 ISO PID PID:200202 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Sp1 Sp1 transcription factor ISO PID PID:200036 PID:200202 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tert telomerase reverse transcriptase ISO PID PID:200202 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tf transferrin ISO PID PID:200202 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tff3 trefoil factor 3 ISO PID PID:200202 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Tfrc transferrin receptor ISO PID PID:200202 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO PID PID:200036 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO PID PID:200036 PID:200202 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO
IDA		 PID
RGD		 PMID:15611513 PMID:15063765 PMID:19364912 PID:200036, RGD:1358257, RGD:1580561, RGD:6483358 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      transcription factor mediated signaling pathway 460
        hypoxia inducible factor pathway 93
          altered hypoxia inducible factor pathway 1
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          oxygen homeostasis pathway 93
            hypoxia inducible factor pathway 93
              altered hypoxia inducible factor pathway 1
paths to the root