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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered Notch signaling pathway involving the macromolecules modifying the main players
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Accession:PW:0000341 term browser browse the term
Definition:An altered Notch signaling pathway due to mutation(s) in the enzymes, macromolecules that act upon the main players. They include proteases, elements of the proteo- and glucosaminoglycan metabolic pathways, ubiquitin ligases, other proteins that modulate availability, sensitivity, endocytosis of ligands/receptors.


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altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Numb NUMB, endocytic adaptor protein ISS In humans, loss of Numb regulation over Notch is involved in breast cancer. RGD PMID:15492044 RGD:1334451 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
G Psen2 presenilin 2 ISO C. elegans transgenics expressing human wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      altered signaling pathway 116
        altered signaling pathway pertinent to development 34
          altered Notch signaling pathway 11
            altered Notch signaling pathway involving the macromolecules modifying the main players 3
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      cell adhesion signaling pathway 413
        cell-cell signaling pathway 253
          Notch signaling pathway 90
            altered Notch signaling pathway 11
              altered Notch signaling pathway involving the macromolecules modifying the main players 3
paths to the root