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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium/calmodulin dependent kinase signaling pathway
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Accession:PW:0000316 term browser browse the term
Definition:The multifunctional calcium/calmodulin-dependent serine/threonine kinases (CAMKs) play important regulatory roles in the cardiac, muscle, nervous and immune tissues. They are represented by CAMK2 whose Ca2+/CaM binding leads to autophosphorylation and activation and the CAMK cascades that depend on an upstream CAMK kinase (CAMKK) for phosphorylation of an 'activation loop' and subsequent activation. CAMK1 and CAMK4 are the two CAMK signaling cascades.
Synonyms:related_synonym: CaMK signaling pathway;   calmodulin dependent kinase signaling pathway


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calcium/calmodulin dependent kinase signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednrb endothelin receptor type B IMP RGD PMID:15245872 RGD:1581866 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
calcium/calmodulin dependent kinase 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:23091085 RGD:7240708 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:23091085 RGD:7240708 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106 		JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 ISO RGD PMID:22334212 RGD:7240704 NCBI chr 7:109,572,838...109,698,516
Ensembl chr 7:109,574,459...109,697,227 		JBrowse link
G Calm1 calmodulin 1 ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO RGD PMID:22334212 PMID:22717267 RGD:7240704, RGD:7240705 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO RGD PMID:22334212 PMID:22717267 RGD:7240704, RGD:7240705 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma ISO RGD PMID:22717267 RGD:7240705 NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO RGD PMID:21070840 PMID:21301225 RGD:7240706, RGD:7240707 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 ISO RGD PMID:21070840 PMID:21301225 RGD:7240706, RGD:7240707 NCBI chr11:80,289,702...80,290,829 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO RGD PMID:22717267 RGD:7240705 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO RGD PMID:22334212 RGD:7240704 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO RGD PMID:22717267 RGD:7240705 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:22717267 RGD:7240705 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:22334212 PMID:22717267 RGD:7240704, RGD:7240705 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Hdac4 histone deacetylase 4 ISO RGD PMID:21255680 RGD:7241019 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 ISO RGD PMID:21255680 RGD:7241019 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Lrrc7 leucine rich repeat containing 7 ISO RGD PMID:22717267 RGD:7240705 NCBI chr 2:247,146,616...247,634,945
Ensembl chr 2:247,147,752...247,634,547 		JBrowse link
G Pln phospholamban ISO RGD PMID:23091085 RGD:7240708 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E ISO RGD PMID:18454172 RGD:7241020 NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282 		JBrowse link
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F TAS RGD PMID:18454172 RGD:7241020 NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma ISO RGD PMID:18454172 RGD:7241020 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha TAS RGD PMID:18454172 RGD:7241020 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO RGD PMID:23091085 RGD:7240708 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO RGD PMID:23091085 RGD:7240708 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 ISO RGD PMID:22717267 RGD:7240705 NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      calcium/calcium-mediated signaling pathway 272
        calcium/calmodulin dependent signaling pathway 38
          calcium/calmodulin dependent kinase signaling pathway 29
            calcium/calmodulin dependent kinase 2 signaling pathway 28
            calcium/calmodulin dependent kinase signaling cascade + 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          metal homeostasis pathway 339
            calcium homeostasis pathway 277
              calcium/calcium-mediated signaling pathway 272
                calcium/calmodulin dependent signaling pathway 38
                  calcium/calmodulin dependent kinase signaling pathway 29
                    calcium/calmodulin dependent kinase 2 signaling pathway 28
                    calcium/calmodulin dependent kinase signaling cascade + 0
paths to the root