p53-dependent G1/S DNA damage checkpoint pathway - Ontology Report

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Term:	p53-dependent G1/S DNA damage checkpoint pathway	go back to main search page
Accession:	PW:0000303	browse the term
Definition:	The p53-dependent pathway of G1 arrest in response to damaged DNA.
Synonyms:	related_synonym:	ATM pathway

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p53-dependent G1/S DNA damage checkpoint pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Ccne1	cyclin E1		IEA	1	90,568,189	90,577,426	RGD:1358139	RGD
G	Tp53	tumor protein p53		IEA	10	56,399,721	56,411,150	RGD:1358139	RGD
altered p53 signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Mdm2	p53 E3 ubiquitin protein ligase		ISS	7	56,996,694	57,020,926	RGD:2316186	RGD
G	Tp53	tumor protein p53		ISS	10	56,399,721	56,411,150	RGD:4143515	RGD
G	Tp53	tumor protein p53		ISS	10	56,399,721	56,411,150	RGD:2316186	RGD
G	Tp53	tumor protein p53		ISS	10	56,399,721	56,411,150	RGD:5490966	RGD
G	Tp53	tumor protein p53		ISS	10	56,399,721	56,411,150	RGD:5133242	RGD
p53 signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		ISO	3	10,804,594	10,907,162	RGD:6484113	PID
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		ISO	6	137,640,482	137,657,552	RGD:6484113	PID
G	Apaf1	apoptotic peptidase activating factor 1		IEA	7	27,932,908	28,020,533	RGD:6907045	KEGG
G	Atm	ataxia telangiectasia mutated		ISS	8	56,894,746	56,996,565	RGD:2316156	RGD
G	Atm	ataxia telangiectasia mutated		ISS	8	56,894,746	56,996,565	RGD:2316155	RGD
G	Atm	ataxia telangiectasia mutated		ISO	8	56,894,746	56,996,565	RGD:6484113	PID
G	Atm	ataxia telangiectasia mutated		IEA	8	56,894,746	56,996,565	RGD:6907045	KEGG
G	Bai1	brain-specific angiogenesis inhibitor 1		IEA	7	112,622,235	112,682,897	RGD:6907045	KEGG
G	Bax	Bcl2-associated X protein		IEA	1	95,933,023	95,938,176	RGD:6907045	KEGG
G	Bbc3	Bcl-2 binding component 3		IEA				RGD:6907045	KEGG
G	Bid	BH3 interacting domain death agonist		IEA	4	157,296,383	157,318,481	RGD:6907045	KEGG
G	Casp3	caspase 3		IEA	16	48,944,226	48,962,420	RGD:6907045	KEGG
G	Casp8	caspase 8		IEA	9	57,389,353	57,437,803	RGD:6907045	KEGG
G	Casp9	caspase 9, apoptosis-related cysteine peptidase		IEA	5	160,704,234	160,721,796	RGD:6907045	KEGG
G	Ccna2	cyclin A2		ISO	2	123,062,752	123,069,085	RGD:6484113	PID
G	Ccnb1	cyclin B1		IEA	2	31,574,600	31,581,784	RGD:6907045	KEGG
G	Ccnb2	cyclin B2		IEA	8	74,892,108	74,906,181	RGD:6907045	KEGG
G	Ccnb3	cyclin B3		IEA	X	27,565,661	27,623,293	RGD:6907045	KEGG
G	Ccnd1	cyclin D1		IEA	1	205,357,235	205,366,757	RGD:6907045	KEGG
G	Ccnd2	cyclin D2		IEA	4	163,523,817	163,546,501	RGD:6907045	KEGG
G	Ccnd3	cyclin D3		IEA				RGD:6907045	KEGG
G	Ccne1	cyclin E1		IEA	1	90,568,189	90,577,426	RGD:6907045	KEGG
G	Ccne2	cyclin E2		IEA	5	25,032,748	25,044,509	RGD:6907045	KEGG
G	Ccng1	cyclin G1		ISO	10	25,776,380	25,782,754	RGD:6484113	PID
G	Ccng1	cyclin G1		IEA	10	25,776,380	25,782,754	RGD:6907045	KEGG
G	Ccng2	cyclin G2		IEA	14	16,338,132	16,346,628	RGD:6907045	KEGG
G	Cd82	Cd82 molecule		IEA	3	77,831,771	77,875,764	RGD:6907045	KEGG
G	Cdk1	cyclin-dependent kinase 1		IEA	20	20,018,044	20,044,030	RGD:6907045	KEGG
G	Cdk2	cyclin dependent kinase 2		ISO	7	2,000,196	2,007,682	RGD:6484113	PID
G	Cdk2	cyclin dependent kinase 2		IEA	7	2,000,196	2,007,682	RGD:6907045	KEGG
G	Cdk4	cyclin-dependent kinase 4		IEA				RGD:6907045	KEGG
G	Cdk6	cyclin-dependent kinase 6		IEA	4	27,362,656	27,618,006	RGD:6907045	KEGG
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		IEA	20	7,376,325	7,386,778	RGD:6907045	KEGG
G	Cdkn2a	cyclin-dependent kinase inhibitor 2A		IEA	5	108,908,749	108,916,380	RGD:6907045	KEGG
G	Chek1	checkpoint kinase 1		ISS	8	37,954,322	37,974,748	RGD:2316156	RGD
G	Chek1	checkpoint kinase 1		ISS	8	37,954,322	37,974,748	RGD:2316155	RGD
G	Chek1	checkpoint kinase 1		ISO	8	37,954,322	37,974,748	RGD:6484113	PID
G	Chek1	checkpoint kinase 1		IEA	8	37,954,322	37,974,748	RGD:6907045	KEGG
G	Chek2	checkpoint kinase 2		ISS	12	45,933,900	45,965,427	RGD:2316155	RGD
G	Chek2	checkpoint kinase 2		ISS	12	45,933,900	45,965,427	RGD:2316156	RGD
G	Chek2	checkpoint kinase 2		ISO	12	45,933,900	45,965,427	RGD:6484113	PID
G	Chek2	checkpoint kinase 2		IEA	12	45,933,900	45,965,427	RGD:6907045	KEGG
G	Crebbp	CREB binding protein		ISS	10	11,598,680	11,724,122	RGD:2316155	RGD
G	Crebbp	CREB binding protein		ISO	10	11,598,680	11,724,122	RGD:6484113	PID
G	Cse1l	CSE1 chromosome segregation 1-like (yeast)		ISO	3	158,061,678	158,100,065	RGD:6484113	PID
G	Csnk1a1	casein kinase 1, alpha 1		ISO	18	57,541,673	57,564,560	RGD:6484113	PID
G	Csnk1d	casein kinase 1, delta		ISO	10	110,166,244	110,197,233	RGD:6484113	PID
G	Csnk1e	casein kinase 1, epsilon		ISO	7	117,402,718	117,420,764	RGD:6484113	PID
G	Csnk1g1	casein kinase 1, gamma 1		ISO	8	70,193,231	70,301,592	RGD:6484113	PID
G	Csnk1g2	casein kinase 1, gamma 2		ISO	7	10,587,247	10,620,696	RGD:6484113	PID
G	Csnk1g3	casein kinase 1, gamma 3		ISO	18	49,369,579	49,451,893	RGD:6484113	PID
G	Cycs	cytochrome c, somatic		IEA	4	78,825,878	78,827,978	RGD:6907045	KEGG
G	Cyct	cytochrome c, testis		IEA	3	59,042,806	59,045,988	RGD:6907045	KEGG
G	Daxx	death-domain associated protein		ISO	20	5,121,854	5,127,601	RGD:6484113	PID
G	Dyrk2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2		ISO	7	58,114,127	58,126,547	RGD:6484113	PID
G	E4f1	E4F transcription factor 1		ISO	10	13,701,558	13,713,008	RGD:6484113	PID
G	Ei24	etoposide induced 2.4		IEA	8	38,028,043	38,044,316	RGD:6907045	KEGG
G	Ep300	E1A binding protein p300		ISO	7	119,938,507	120,008,886	RGD:6484113	PID
G	Fas	Fas (TNF receptor superfamily, member 6)		IEA	1	238,259,443	238,274,745	RGD:6907045	KEGG
G	Fbxo11	F-box protein 11		ISO	6	11,542,561	11,566,829	RGD:6484113	PID
G	Gadd45a	growth arrest and DNA-damage-inducible, alpha		IEA	4	96,649,941	96,652,243	RGD:6907045	KEGG
G	Gadd45b	growth arrest and DNA-damage-inducible, beta		IEA	7	10,289,073	10,291,102	RGD:6907045	KEGG
G	Gadd45g	growth arrest and DNA-damage-inducible, gamma		IEA	17	19,230,896	19,232,641	RGD:6907045	KEGG
G	Gsk3b	glycogen synthase kinase 3 beta		ISO	11	64,284,731	64,428,698	RGD:6484113	PID
G	Gtse1	G-2 and S-phase expressed 1		IEA	7	123,862,066	123,878,554	RGD:6907045	KEGG
G	Hdac1	histone deacetylase 1		ISS	5	148,672,515	148,699,810	RGD:2316155	RGD
G	Hipk2	homeodomain interacting protein kinase 2		ISO	4	66,273,623	66,455,774	RGD:6484113	PID
G	Igf1	insulin-like growth factor 1		IEA	7	24,531,669	24,605,742	RGD:6907045	KEGG
G	Igfbp3	insulin-like growth factor binding protein 3		IEA	14	87,959,153	87,967,085	RGD:6907045	KEGG
G	Kat5	K(lysine) acetyltransferase 5		ISS	1	208,233,434	208,240,738	RGD:2316155	RGD
G	Kat5	K(lysine) acetyltransferase 5		ISO	1	208,233,434	208,240,738	RGD:6484113	PID
G	Kat8	K (lysine) acetyltransferase 8		ISS	1	187,198,682	187,210,962	RGD:2316155	RGD
G	Kat8	K (lysine) acetyltransferase 8		ISO	1	187,198,682	187,210,962	RGD:6484113	PID
G	Mapk14	mitogen activated protein kinase 14		ISO	20	6,939,249	7,000,378	RGD:6484113	PID
G	Mapk8	mitogen-activated protein kinase 8		ISO	16	8,925,133	9,004,897	RGD:6484113	PID
G	Mapk9	mitogen-activated protein kinase 9		ISO	10	35,353,486	35,384,319	RGD:6484113	PID
G	Mdm2	p53 E3 ubiquitin protein ligase		ISS	7	56,996,694	57,020,926	RGD:2316155	RGD
G	Mdm2	p53 E3 ubiquitin protein ligase		ISS	7	56,996,694	57,020,926	RGD:2316156	RGD
G	Mdm2	p53 E3 ubiquitin protein ligase		ISO	7	56,996,694	57,020,926	RGD:6484113	PID
G	Mdm2	p53 E3 ubiquitin protein ligase		IEA	7	56,996,694	57,020,926	RGD:6907045	KEGG
G	Mdm4	Mdm4 p53 binding protein homolog (mouse)		ISS	13	45,895,832	45,931,421	RGD:2316155	RGD
G	Mdm4	Mdm4 p53 binding protein homolog (mouse)		ISS	13	45,895,832	45,931,421	RGD:2316156	RGD
G	Mdm4	Mdm4 p53 binding protein homolog (mouse)		ISO	13	45,895,832	45,931,421	RGD:6484113	PID
G	Mdm4	Mdm4 p53 binding protein homolog (mouse)		IEA	13	45,895,832	45,931,421	RGD:6907045	KEGG
G	Nedd8	neural precursor cell expressed, developmentally down-regulated 8		ISO	15	33,797,457	33,820,624	RGD:6484113	PID
G	Perp	PERP, TP53 apoptosis effector		IEA	1	13,976,356	13,988,803	RGD:6907045	KEGG
G	Pin1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1		ISO	8	19,669,537	19,681,741	RGD:6484113	PID
G	Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1		IEA	18	62,914,845	62,918,832	RGD:6907045	KEGG
G	Ppm1d	protein phosphatase, Mg2+/Mn2+ dependent, 1D		ISO	10	73,575,506	73,612,063	RGD:6484113	PID
G	Ppm1d	protein phosphatase, Mg2+/Mn2+ dependent, 1D		IEA	10	73,575,506	73,612,063	RGD:6907045	KEGG
G	Ppp1r13l	protein phosphatase 1, regulatory subunit 13 like		ISO	1	78,727,071	78,896,831	RGD:6484113	PID
G	Ppp2ca	protein phosphatase 2, catalytic subunit, alpha isozyme		ISO	10	37,621,256	37,641,008	RGD:6484113	PID
G	Ppp2r4	protein phosphatase 2A activator, regulatory subunit 4		ISO	3	9,461,718	9,492,181	RGD:6484113	PID
G	Prkcd	protein kinase C, delta		ISO	16	5,954,218	5,975,743	RGD:6484113	PID
G	Prmt5	protein arginine methyltransferase 5		ISO	15	32,574,951	32,584,336	RGD:6484113	PID
G	Pten	phosphatase and tensin homolog		IEA	1	236,771,027	236,837,261	RGD:6907045	KEGG
G	Rassf1	Ras association (RalGDS/AF-6) domain family member 1		ISO	8	112,798,863	112,810,004	RGD:6484113	PID
G	Rchy1	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase		ISS	14	17,683,377	17,698,982	RGD:2316155	RGD
G	Rchy1	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase		ISO	14	17,683,377	17,698,982	RGD:6484113	PID
G	Rchy1	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase		IEA	14	17,683,377	17,698,982	RGD:6907045	KEGG
G	Rfwd2	ring finger and WD repeat domain 2		IEA	13	74,552,876	74,590,608	RGD:6907045	KEGG
G	Rpl11	ribosomal protein L11		ISO	5	154,826,973	154,830,183	RGD:6484113	PID
G	Rpl23	ribosomal protein L23		ISO	10	86,527,589	86,531,549	RGD:6484113	PID
G	Rpl5l1	ribosomal protein L5-like 1		ISO	9	113,233,164	113,234,057	RGD:6484113	PID
G	Rprm	reprimo, TP53 dependent G2 arrest mediator candidate		IEA	3	35,590,166	35,591,583	RGD:6907045	KEGG
G	Rrm2	ribonucleotide reductase M2		IEA	6	42,350,541	42,356,748	RGD:6907045	KEGG
G	Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)		IEA	7	73,432,161	73,459,541	RGD:6907045	KEGG
G	Serpinb5	serpin peptidase inhibitor, clade B (ovalbumin), member 5		IEA	13	13,037,587	13,057,785	RGD:6907045	KEGG
G	Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1		IEA	12	20,931,996	20,942,374	RGD:6907045	KEGG
G	Sesn1	sestrin 1		IEA	20	45,786,623	45,877,856	RGD:6907045	KEGG
G	Sesn3	sestrin 3		IEA	8	11,076,055	11,125,523	RGD:6907045	KEGG
G	Setd7	SET domain containing (lysine methyltransferase) 7		ISS	2	140,413,802	140,456,579	RGD:2316155	RGD
G	Setd7	SET domain containing (lysine methyltransferase) 7		ISO	2	140,413,802	140,456,579	RGD:6484113	PID
G	Sfn	stratifin		IEA	5	151,475,395	151,479,996	RGD:6907045	KEGG
G	Shisa5	shisa homolog 5 (Xenopus laevis)		IEA	8	114,068,670	114,071,301	RGD:6907045	KEGG
G	Siah1a	seven in absentia 1A		IEA	19	21,717,141	21,740,751	RGD:6907045	KEGG
G	Sirt1	sirtuin 1		ISS	20	25,675,302	25,686,494	RGD:2316155	RGD
G	Skp2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase		ISO	2	58,769,164	58,797,229	RGD:6484113	PID
G	Smyd2	SET and MYND domain containing 2		ISS	13	106,160,147	106,201,473	RGD:2316155	RGD
G	Smyd2	SET and MYND domain containing 2		ISO	13	106,160,147	106,201,473	RGD:6484113	PID
G	Steap3	STEAP family member 3, metalloreductase		IEA				RGD:6907045	KEGG
G	Tp53	tumor protein p53		ISS	10	56,399,721	56,411,150	RGD:2316155	RGD
G	Tp53	tumor protein p53		ISS	10	56,399,721	56,411,150	RGD:2316156	RGD
G	Tp53	tumor protein p53		ISO	10	56,399,721	56,411,150	RGD:6484113	PID
G	Tp53	tumor protein p53		IEA	10	56,399,721	56,411,150	RGD:6907045	KEGG
G	Tp73	tumor protein p73		IEA	5	170,848,979	171,078,739	RGD:6907045	KEGG
G	Trim28	tripartite motif-containing 28		ISO	1	72,892,399	72,899,070	RGD:6484113	PID
G	Tsc2	tuberous sclerosis 2		IEA	10	13,848,210	13,883,189	RGD:6907045	KEGG
G	Ttc5	tetratricopeptide repeat domain 5		ISO	15	26,749,259	26,766,848	RGD:6484113	PID
G	Ube2d1	ubiquitin-conjugating enzyme E2D 1		ISO	20	18,040,687	18,086,179	RGD:6484113	PID
G	Usp7	ubiquitin specific peptidase 7 (herpes virus-associated)		ISS	10	6,917,612	6,963,452	RGD:2316155	RGD
G	Usp7	ubiquitin specific peptidase 7 (herpes virus-associated)		ISO	10	6,917,612	6,963,452	RGD:6484113	PID
G	Yy1	YY1 transcription factor		ISO	6	133,132,419	133,156,686	RGD:6484113	PID
G	Zmat3	zinc finger, matrin type 3		IEA	2	118,526,985	118,537,727	RGD:6907045	KEGG

Term paths to the root

Path 1
Term	Annotations
Pathway Ontology	17140
regulatory pathway	5692
pathways of replication, repair, gene expression, protein biosynthesis	1586
cell cycle checkpoint pathway	151
G1/S DNA damage checkpoint pathway	142
p53-dependent G1/S DNA damage checkpoint pathway	141
p53 signaling pathway +	139