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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:G protein mediated signaling pathway via Galphaq family
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Accession:PW:0000229 term browser browse the term
Definition:Based on sequence similarity, the Galpha genes have been grouped into four classes. Exchange of GDP to GTP promoted through binding to receptors dissociates the heterotrimeric Galpha/beta/gamma complex. GTP-bound Galpha can then interact with downstream effectors. Lipid modification of Galpha regulates membrane localization and interactions with specific effectors.


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G protein mediated signaling pathway via Galphaq family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISS RGD PMID:11454900 RGD:1559318 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B ISS RGD PMID:11454900 RGD:1559318 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D ISS RGD PMID:11454900 RGD:1559318 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:11906170 PMID:12446719 RGD:70819, RGD:629553 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO
IDA		 RGD PMID:14624682 PMID:19047484 RGD:1579891, RGD:2312649 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Casr calcium-sensing receptor IMP RGD PMID:22192592 PMID:12239094 RGD:7207059, RGD:7207227 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 ISO RGD PMID:23841840 RGD:8549585 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Drd1 dopamine receptor D1 ISO D1-D2 heterodimer RGD PMID:25671228 RGD:11041142 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 ISO D1-D2 heterodimer RGD PMID:25671228 RGD:11041142 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:25671228 RGD:11041142 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Ghsr growth hormone secretagogue receptor TAS RGD PMID:15788704 RGD:1642818 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:14624682 PMID:11395409 PMID:23759942 RGD:1579891, RGD:5131495, RGD:8549590 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gna14 G protein subunit alpha 14 ISO RGD PMID:11395409 PMID:23759942 RGD:5131495, RGD:8549590 NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423 		JBrowse link
G Gna15 G protein subunit alpha 15 IMP
ISO		 RGD PMID:9685675 PMID:11395409 RGD:728647, RGD:5131495 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508 		JBrowse link
G Gnaq G protein subunit alpha q IMP
ISO		 RGD PMID:12890892 PMID:14624682 PMID:11395409 PMID:23759942 RGD:1642020, RGD:1579891, RGD:5131495, RGD:8549590 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Hcrtr1 hypocretin receptor 1 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674 		JBrowse link
G Hcrtr2 hypocretin receptor 2 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IMP RGD PMID:16504475 RGD:1626471 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 IMP RGD PMID:16504475 RGD:1626471 NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357 		JBrowse link
G Oxtr oxytocin receptor ISO
IMP		 RGD PMID:14624682 PMID:9575824 RGD:1579891, RGD:2304227 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb2 phospholipase C, beta 2 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcb3 phospholipase C beta 3 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plcb4 phospholipase C, beta 4 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Pth1r parathyroid hormone 1 receptor IDA
ISO		 RGD PMID:9054374 PMID:21777186 PMID:19395963 RGD:7207455, RGD:7207465, RGD:7207470 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 PMID:12239094 RGD:5133418, RGD:7207227 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      G protein mediated signaling pathway 160
        heterotrimeric G protein mediated signaling pathway 78
          G protein mediated signaling pathway via Galphaq family 33
paths to the root