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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:G1/S transition pathway
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Accession:PW:0000088 term browser browse the term
Definition:The series of events underlying the transition from G1 into S phase and under the control of Cyclin E/A - Cdk2 and cyclin D-Cdk4/Cdk6 complexes and their regulators. Genetic alterations of this important transition point are frequent in human cancers.
Synonyms:related_synonym: G1/S Transition;   G1/S transition of mitotic cell cycle


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G1/S transition pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna1 cyclin A1 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143, RGD:8694150 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccna2 cyclin A2 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143, RGD:8694150 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 IEA RGD PMID: RGD:1358139 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 ISO RGD PMID:10919634 RGD:8694143 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 ISO RGD PMID:10919634 RGD:8694143 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 ISO RGD PMID:10919634 RGD:8694143 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 IEA
ISO		 RGD PMID: PMID:10919634 PMID:16236519 RGD:1358139, RGD:8694143, RGD:8694150 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143, RGD:8694150 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 IEA RGD PMID: RGD:1358139 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143, RGD:8694150 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143, RGD:8694150 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143, RGD:8694150 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO RGD PMID:10919634 RGD:8694143 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B ISO RGD PMID:10919634 RGD:8694143 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C ISO RGD PMID:10919634 RGD:8694143 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO RGD PMID:10919634 RGD:8694143 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B ISO RGD PMID:10919634 RGD:8694143 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C ISO RGD PMID:10919634 RGD:8694143 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D ISO RGD PMID:10919634 RGD:8694143 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO RGD PMID:16236519 RGD:8694150 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 ISO RGD PMID:16236519 RGD:8694150 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 ISO RGD PMID:16236519 RGD:8694150 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
altered G1/S transition pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO RGD PMID:18772397 RGD:5490966 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1752
        cell cycle pathway 214
          cell cycle pathway, mitotic 114
            G1/S transition pathway 22
              altered G1/S transition pathway 1
paths to the root