ONTOLOGY REPORT - ANNOTATIONS

Term:steroid hormone biosynthetic pathway
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Accession:PW:0000040 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of steroid hormones. All steroid hormones are derived from cholesterol. Steroid hormone metabolism is extremely complex and its molecular details are incompletely understood. De novo steroid biosynthesis is confined to very few tissues, primarily the adrenals, the gonads and the placenta.
Synonyms:related_synonym: KEGG:00140
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steroid hormone biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akr1d1 aldo-keto reductase family 1, member D1 GBrowse link IEA 4 64,972,908 65,005,896 RGD:6907045 KEGG
G Comt catechol-O-methyltransferase GBrowse link IEA 11 84,561,591 84,581,713 RGD:6907045 KEGG
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link IEA 8 61,793,976 61,805,308 RGD:6907045 KEGG
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link ISS 8 61,793,976 61,805,308 RGD:2325883 RGD
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 GBrowse link IEA 7 112,977,395 112,984,080 RGD:6907045 KEGG
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 GBrowse link IEA 7 113,043,365 113,049,779 RGD:6907045 KEGG
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 GBrowse link IEA 7 113,013,335 113,018,824 RGD:6907045 KEGG
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link IEA 1 251,965,458 251,971,449 RGD:6907045 KEGG
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link ISS 1 251,965,458 251,971,449 RGD:2325883 RGD
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISS RGD:4889549 RGD
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEA RGD:6907045 KEGG
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 GBrowse link IEA 8 61,462,207 61,468,237 RGD:6907045 KEGG
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 GBrowse link IEA 6 2,548,224 2,553,767 RGD:6907045 KEGG
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 GBrowse link IEA 20 4,125,357 4,128,518 RGD:6907045 KEGG
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 GBrowse link IEA 12 9,086,752 9,136,606 RGD:6907045 KEGG
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link IEA 12 9,517,016 9,541,000 RGD:6907045 KEGG
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 GBrowse link IEA 12 9,567,120 9,595,974 RGD:6907045 KEGG
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 GBrowse link IEA 12 17,164,384 17,204,589 RGD:6907045 KEGG
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 GBrowse link IEA 5 19,707,159 19,716,856 RGD:6907045 KEGG
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 GBrowse link IEA 2 103,102,679 103,271,273 RGD:6907045 KEGG
G Fdx1 ferredoxin 1 GBrowse link ISS 8 55,291,396 55,310,507 RGD:2325883 RGD
G Fdxr ferredoxin reductase GBrowse link ISS 10 105,342,684 105,351,374 RGD:2325883 RGD
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 GBrowse link IEA 13 109,063,491 109,089,468 RGD:6907045 KEGG
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 GBrowse link IEA 19 35,336,342 35,341,585 RGD:6907045 KEGG
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 GBrowse link IEA 10 90,094,249 90,096,451 RGD:6907045 KEGG
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 GBrowse link IEA 3 78,436,634 78,559,707 RGD:6907045 KEGG
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 GBrowse link IEA 19 47,729,519 47,802,933 RGD:6907045 KEGG
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 GBrowse link IEA 17 6,554,164 6,585,525 RGD:6907045 KEGG
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 GBrowse link IEA 7 1,118,183 1,137,670 RGD:6907045 KEGG
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 GBrowse link IEA 13 85,776,077 85,792,977 RGD:6907045 KEGG
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 GBrowse link IEA 20 4,964,860 4,966,855 RGD:6907045 KEGG
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 GBrowse link IEA 2 193,337,342 193,346,799 RGD:6907045 KEGG
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 GBrowse link ISS 2 193,337,342 193,346,799 RGD:4889549 RGD
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 GBrowse link ISS 2 193,500,916 193,507,633 RGD:4889549 RGD
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 GBrowse link IEA 2 193,249,949 193,269,979 RGD:6907045 KEGG
G Por P450 (cytochrome) oxidoreductase GBrowse link ISS 12 22,078,629 22,097,301 RGD:2325883 RGD
G Srd5a1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) GBrowse link IEA 17 3,845,190 3,879,165 RGD:6907045 KEGG
G Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) GBrowse link IEA 6 21,453,521 21,489,408 RGD:6907045 KEGG
G Srd5a3 steroid 5 alpha-reductase 3 GBrowse link IEA 14 34,318,370 34,333,413 RGD:6907045 KEGG
G Star steroidogenic acute regulatory protein GBrowse link TAS 16 70,642,580 70,647,203 RGD:2325883 RGD
G Sts steroid sulfatase (microsomal), isozyme S GBrowse link IEA X 63,915,803 63,923,834 RGD:6907045 KEGG
G Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 GBrowse link IEA 14 21,948,475 21,965,541 RGD:6907045 KEGG
G Sult2a2 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 IEA RGD:6907045 KEGG
G Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 GBrowse link IEA 1 96,197,902 96,261,672 RGD:6907045 KEGG
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 GBrowse link IEA 9 87,091,241 87,098,362 RGD:6907045 KEGG
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 GBrowse link IEA 9 87,081,132 87,098,362 RGD:6907045 KEGG
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 GBrowse link IEA 9 87,070,247 87,098,362 RGD:6907045 KEGG
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 GBrowse link IEA 9 87,052,169 87,098,362 RGD:6907045 KEGG
G Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 GBrowse link IEA 9 87,037,154 87,098,362 RGD:6907045 KEGG
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C GBrowse link IEA 9 87,029,500 87,098,362 RGD:6907045 KEGG
G Ugt1a8 UDP glycosyltransferase 1 family, polypeptide A8 GBrowse link IEA 9 87,017,029 87,098,362 RGD:6907045 KEGG
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 GBrowse link IEA 9 86,986,915 87,098,362 RGD:6907045 KEGG
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 GBrowse link IEA 14 22,047,612 22,071,582 RGD:6907045 KEGG
G Ugt2a3 UDP glucuronosyltransferase 2 family, polypeptide A3 GBrowse link IEA 14 22,099,350 22,116,820 RGD:6907045 KEGG
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B GBrowse link IEA 14 22,154,370 22,178,222 RGD:6907045 KEGG
G Ugt2b17 UDP glucuronosyltransferase 2 family, polypeptide B17 GBrowse link IEA 14 22,639,182 22,650,931 RGD:6907045 KEGG
G Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 GBrowse link IEA 14 22,404,705 22,421,315 RGD:6907045 KEGG
aldosterone biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link ISS 8 61,793,976 61,805,308 RGD:4892309 RGD
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 GBrowse link ISS 7 112,977,395 112,984,080 RGD:4889549 RGD
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 GBrowse link TAS 7 113,043,365 113,049,779 RGD:4889549 RGD
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 GBrowse link ISS 20 4,125,357 4,128,518 RGD:4889549 RGD
G Fdx1 ferredoxin 1 GBrowse link ISS 8 55,291,396 55,310,507 RGD:2325883 RGD
G Fdxr ferredoxin reductase GBrowse link ISS 10 105,342,684 105,351,374 RGD:2325883 RGD
G Por P450 (cytochrome) oxidoreductase GBrowse link ISS 12 22,078,629 22,097,301 RGD:4892309 RGD
G Star steroidogenic acute regulatory protein GBrowse link ISS 16 70,642,580 70,647,203 RGD:2325883 RGD
C21-steroid hormone biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 GBrowse link IDA 7 113,043,365 113,049,779 RGD:727991 RGD
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 GBrowse link IDA 7 113,013,335 113,018,824 RGD:1299585 RGD
cortisol biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link ISS 8 61,793,976 61,805,308 RGD:4892309 RGD
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 GBrowse link ISS 7 112,977,395 112,984,080 RGD:4889549 RGD
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link ISS 1 251,965,458 251,971,449 RGD:4892309 RGD
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 GBrowse link ISS 20 4,125,357 4,128,518 RGD:4889549 RGD
G Fdx1 ferredoxin 1 GBrowse link ISS 8 55,291,396 55,310,507 RGD:2325883 RGD
G Fdxr ferredoxin reductase GBrowse link ISS 10 105,342,684 105,351,374 RGD:2325883 RGD
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 GBrowse link ISS 2 193,337,342 193,346,799 RGD:4889549 RGD
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 GBrowse link ISS 2 193,500,916 193,507,633 RGD:4889549 RGD
G Por P450 (cytochrome) oxidoreductase GBrowse link ISS 12 22,078,629 22,097,301 RGD:4892309 RGD
G Star steroidogenic acute regulatory protein GBrowse link ISS 16 70,642,580 70,647,203 RGD:2325883 RGD
estradiol biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link ISS 8 61,793,976 61,805,308 RGD:4892309 RGD
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link ISS 1 251,965,458 251,971,449 RGD:4892309 RGD
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISS RGD:2325883 RGD
G Fdx1 ferredoxin 1 GBrowse link ISS 8 55,291,396 55,310,507 RGD:2325883 RGD
G Fdxr ferredoxin reductase GBrowse link ISS 10 105,342,684 105,351,374 RGD:2325883 RGD
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 GBrowse link TAS 10 90,094,249 90,096,451 RGD:4889549 RGD
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 GBrowse link ISS 10 90,094,249 90,096,451 RGD:2325883 RGD
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 GBrowse link ISS 19 47,729,519 47,802,933 RGD:4889549 RGD
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 GBrowse link ISS 17 6,554,164 6,585,525 RGD:2325883 RGD
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 GBrowse link ISS 2 193,337,342 193,346,799 RGD:4889549 RGD
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 GBrowse link ISS 2 193,500,916 193,507,633 RGD:4889549 RGD
G Por P450 (cytochrome) oxidoreductase GBrowse link ISS 12 22,078,629 22,097,301 RGD:4892309 RGD
G Star steroidogenic acute regulatory protein GBrowse link ISS 16 70,642,580 70,647,203 RGD:2325883 RGD
G Sts steroid sulfatase (microsomal), isozyme S GBrowse link ISS X 63,915,803 63,923,834 RGD:6893583 RGD
G Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 GBrowse link ISS 14 21,948,475 21,965,541 RGD:6893583 RGD
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 GBrowse link ISS 1 75,632,632 75,708,022 RGD:2325883 RGD
testosterone biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link ISS 8 61,793,976 61,805,308 RGD:2325883 RGD
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link ISS 1 251,965,458 251,971,449 RGD:2325883 RGD
G Fdx1 ferredoxin 1 GBrowse link ISS 8 55,291,396 55,310,507 RGD:2325883 RGD
G Fdxr ferredoxin reductase GBrowse link ISS 10 105,342,684 105,351,374 RGD:2325883 RGD
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 GBrowse link ISS 19 47,729,519 47,802,933 RGD:4889549 RGD
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 GBrowse link ISS 17 6,554,164 6,585,525 RGD:2325883 RGD
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 GBrowse link ISS 2 193,337,342 193,346,799 RGD:4889549 RGD
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 GBrowse link ISS 2 193,500,916 193,507,633 RGD:4889549 RGD
G Por P450 (cytochrome) oxidoreductase GBrowse link ISS 12 22,078,629 22,097,301 RGD:2325883 RGD
G Srd5a1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) GBrowse link ISS 17 3,845,190 3,879,165 RGD:2325883 RGD
G Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) GBrowse link ISS 6 21,453,521 21,489,408 RGD:2325883 RGD
G Star steroidogenic acute regulatory protein GBrowse link TAS 16 70,642,580 70,647,203 RGD:2325883 RGD
G Sts steroid sulfatase (microsomal), isozyme S GBrowse link ISS X 63,915,803 63,923,834 RGD:6893583 RGD
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 GBrowse link ISS 1 75,632,632 75,708,022 RGD:2325883 RGD
Term paths to the root
Path 1
Term Annotations click to browse term
  Pathway Ontology 17140
    classic metabolic pathway 3638
      lipid metabolic pathway 813
        isoprenoid metabolic pathway 188
          isoprenoid biosynthetic pathway 155
            steroid biosynthetic pathway 155
              steroid hormone biosynthetic pathway 107
                C18-steroid hormone biosynthetic pathway + 16
                C19-steroid hormone biosynthetic pathway + 14
                C21-steroid hormone biosynthetic pathway + 20
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