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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:fatty acid biosynthetic pathway
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Accession:PW:0000029 term browser browse the term
Definition:Acetyl-CoA, the starting material for fatty acid biosynthesis, can be derived from amino acid and lipid degradation or the oxidative decarboxylation of pyruvate. Fatty acid biosynthesis involves the condensation of C2 units; it requires seven enzymatic reactions which are carried out by the multifunctional enzyme fatty acid synthase.
Synonyms:related_synonym: fatty acid biosynthetic process
 alt_id: PW:0000030
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fatty acid biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha IEA
ISO
IDA		 KEGG
SMPDB
RGD		 PMID:11735100 PMID:17882277 SMP:00456 rno:00061, RGD:2317316, RGD:2317309 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acacb acetyl-CoA carboxylase beta IEA KEGG rno:00061 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Acly ATP citrate lyase ISO
IDA		 RGD PMID:17882277 PMID:11735100 RGD:2317309, RGD:2317316 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Fasn fatty acid synthase ISO
IEA
IMP		 SMPDB
KEGG
RGD		 PMID:19181734 PMID:15715522 PMID:17882277 SMP:00456 rno:00061, RGD:2317204, RGD:2317317, RGD:2317309 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Mcat malonyl-CoA-acyl carrier protein transacylase IEA KEGG rno:00061 NCBI chr 7:114,693,612...114,705,677
Ensembl chr 7:114,693,612...114,704,542 		JBrowse link
G Olah oleoyl-ACP hydrolase IEA KEGG rno:00061 NCBI chr17:74,877,651...74,902,517
Ensembl chr17:74,877,655...74,902,518 		JBrowse link
G Oxsm 3-oxoacyl-ACP synthase, mitochondrial IEA KEGG rno:00061 NCBI chr15:9,210,443...9,215,852
Ensembl chr15:9,210,547...9,214,558 		JBrowse link
fatty acid elongation pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 IEA
ISO		 KEGG
SMPDB		 SMP:00054 rno:00062 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 IEA
ISO		 KEGG
SMPDB		 SMP:00054 rno:00062 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase IEA KEGG rno:00062 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha IEA
ISO		 KEGG
SMPDB		 SMP:00054 rno:00062 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta IEA
ISO		 KEGG
SMPDB		 SMP:00054 rno:00062 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 ISO SMPDB SMP:00054 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase IEA
ISO		 KEGG
SMPDB		 SMP:00054 rno:00062 NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 IEA
ISO		 KEGG
SMPDB		 SMP:00054 rno:00062 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Ppt2 palmitoyl-protein thioesterase 2 IEA KEGG rno:00062 NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774 		JBrowse link
unsaturated fatty acid biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A IEA KEGG rno:01040 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B IEA KEGG rno:01040 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 IEA KEGG rno:01040 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 IEA KEGG rno:01040 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acot3 acyl-CoA thioesterase 3 IEA KEGG rno:01040 NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 IEA KEGG rno:01040 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917 		JBrowse link
G Acot5 acyl-CoA thioesterase 5 IEA KEGG rno:01040 NCBI chr 6:103,701,908...103,708,696
Ensembl chr 6:103,701,908...103,708,696 		JBrowse link
G Acot7 acyl-CoA thioesterase 7 IEA KEGG rno:01040 NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309 		JBrowse link
G Acox1 acyl-CoA oxidase 1 IEA KEGG rno:01040 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acox3 acyl-CoA oxidase 3, pristanoyl IEA KEGG rno:01040 NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase IEA KEGG rno:01040 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 IEA KEGG rno:01040 NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 IEA KEGG rno:01040 NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 IEA KEGG rno:01040 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Fads1 fatty acid desaturase 1 IEA KEGG rno:01040 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Fads2 fatty acid desaturase 2 IEA KEGG rno:01040 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 IEA KEGG rno:01040 NCBI chr17:77,081,508...77,106,114
Ensembl chr17:77,083,740...77,106,073 		JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 IEA KEGG rno:01040 NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha IEA KEGG rno:01040 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 IEA KEGG rno:01040 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase IEA KEGG rno:01040 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511 		JBrowse link
G Scd stearoyl-CoA desaturase IEA KEGG rno:01040 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 IEA KEGG rno:01040 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232 		JBrowse link
G Scd4 stearoyl-coenzyme A desaturase 4 IEA KEGG rno:01040 NCBI chr 1:243,203,433...243,216,007
Ensembl chr 1:243,203,881...243,215,148 		JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase IEA KEGG rno:01040 NCBI chr19:24,526,700...24,568,168
Ensembl chr19:24,541,615...24,568,168 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      lipid metabolic pathway 488
        fatty acid metabolic pathway 191
          fatty acid biosynthetic pathway 40
            fatty acid elongation pathway 9
            unsaturated fatty acid biosynthetic pathway 25
paths to the root