ONTOLOGY REPORT - ANNOTATIONS


Term:cardiovascular system phenotype
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Accession:MP:0005385 term browser browse the term
Definition:the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan


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abnormal blood-brain barrier function term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:8657330
G Abcb1aem2Sage ATP binding cassette subfamily B member 1A; ZFN induced mutant 2, Sage RGD:8657330
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:704399
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:704425
abnormal cardiac muscle contractility term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:11565821
G Ttnem1Sage Titin; zinc finger nuclease induced mutant 1,Sigma Advanced Genetic Engineering Labs RGD:11565821
G Ttnem2Sage Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs RGD:11565821
abnormal cardiac muscle relaxation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:1580434
abnormal cardiovascular system physiology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 1 216,293,087 216,630,339 RGD:1581602
G Kcnq1dfk potassium voltage-gated channel subfamily Q member 1;deafness Kyoto RGD:1581602
abnormal choroid vasculature morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:2307226
abnormal circadian regulation of systemic arterial blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Astn1 astrotactin 1 JBrowse link 13 76,054,965 76,370,674 RGD:12792227
G Brinp2 BMP/retinoic acid inducible neural specific 2 JBrowse link 13 75,948,679 76,049,363 RGD:12792227
G Pappa2 pappalysin 2 JBrowse link 13 76,389,150 76,660,248 RGD:12792227
G Rfwd2 ring finger and WD repeat domain 2 JBrowse link 13 76,942,883 77,076,015 RGD:12792227
G Tnr tenascin R JBrowse link 13 77,602,249 77,678,385 RGD:12792227
abnormal heart echocardiography feature term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:12880034
G Dmdem1Ang dystrophin; TALEN-induced mutant1, Ang RGD:12880034
abnormal heart morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5509888
abnormal retinal vasculature morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1581593
abnormal vascular development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cryba1 crystallin, beta A1 JBrowse link 10 65,160,777 65,167,504 RGD:2303652
abnormal vasodilation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc9 ATP binding cassette subfamily C member 9 JBrowse link 4 176,806,098 176,928,540 RGD:704400
G Gpr182 G protein-coupled receptor 182 JBrowse link 7 71,044,786 71,048,713 RGD:61533
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11344212
G Nfe2l2em1Mcwi nuclear factor, erythroid 2-like 2; TALEN induced mutant 1, Medical College of Wisconsin RGD:11344212
altered response to myocardial infarction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580213
calcified artery term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mgp matrix Gla protein JBrowse link 4 170,856,783 170,860,105 RGD:2293588
cardiac fibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5509888
cardiac hypertrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:1549856
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:629553
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1566500
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:1298794
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:1298794
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1580474
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:12910116
G Npr2 natriuretic peptide receptor 2 JBrowse link 5 59,128,186 59,147,321 RGD:1601488
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:1580700
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1580703
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:1581475
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1357201
congestive heart failure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1598759
decreased cardiac muscle relaxation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:11565821
G Ttnem1Sage Titin; zinc finger nuclease induced mutant 1,Sigma Advanced Genetic Engineering Labs RGD:11565821
G Ttnem2Sage Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs RGD:11565821
decreased cardiac stroke volume term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:11565821
G Ttnem2Sage Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs RGD:11565821
decreased heart left ventricle weight term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
decreased heart rate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1625290
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1357163
decreased heart weight term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:12880034
G Dmdem1Ang dystrophin; TALEN-induced mutant1, Ang RGD:12880034
decreased left ventricle developed pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:11565821
G Ttnem2Sage Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs RGD:11565821
decreased mean systemic arterial blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1625290
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6893560
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:1600795
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292104
decreased susceptibility to hypertension term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:13442481
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442481
G Ncf2 neutrophil cytosolic factor 2 JBrowse link 13 70,226,441 70,259,019 RGD:9587793
G Ncf2em1Mcwi neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:9587793
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:11079199
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin RGD:11079199
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:13442483
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442483
decreased systemic arterial blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 JBrowse link 1 35,067,268 35,200,530 RGD:2312639
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1580453
decreased systemic arterial diastolic blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 JBrowse link 1 35,067,268 35,200,530 RGD:9685162
G Adamts16em1Bj ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj RGD:9685162
G Apln apelin JBrowse link X 134,856,719 134,866,210 RGD:1576349
decreased systemic arterial systolic blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 JBrowse link 1 35,067,268 35,200,530 RGD:9685162
G Adamts16em1Bj ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj RGD:9685162
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1625365
G Apln apelin JBrowse link X 134,856,719 134,866,210 RGD:1576349
decreased systemic vascular resistance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:11079199
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin RGD:11079199
decreased vasoconstriction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:4889513
decreased vasodilation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gch1 GTP cyclohydrolase 1 JBrowse link 15 23,935,011 23,968,971 RGD:1601283
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580206
decreased ventricle muscle contractility term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5509888
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:12904914
G Sh2b3em2Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:12904914
dilated heart left ventricle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580213
heart left ventricle hypertrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:1581830
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1580955
heart right ventricle hypertrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1580077
hypertension term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:12911217
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:12910116
increased cardiac output term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:11079199
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin RGD:11079199
increased cardiac stroke volume term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:11079199
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin RGD:11079199
increased heart rate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glp1r glucagon-like peptide 1 receptor JBrowse link 20 9,586,075 9,626,228 RGD:625448
increased heart weight term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:11040981
G Dmdem1Kykn dystrophin; CRISPR/Cas9 system induced mutant 1, Keitaro Yamanouchi RGD:11040981
increased mean systemic arterial blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1599140
increased systemic arterial blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1625366
G Avpr2 arginine vasopressin receptor 2 JBrowse link X 156,889,006 156,892,707 RGD:1298694
G Ddx52 DExD-box helicase 52 JBrowse link 10 71,253,667 71,276,397 RGD:1599269
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:1581856
G Glp1r glucagon-like peptide 1 receptor JBrowse link 20 9,586,075 9,626,228 RGD:625448
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 JBrowse link 10 18,910,586 18,922,856 RGD:1298970
G Npr1 natriuretic peptide receptor 1 JBrowse link 2 189,840,403 189,857,032 RGD:1357231
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:633385
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:61046
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1357163
increased systemic arterial diastolic blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Npr1 natriuretic peptide receptor 1 JBrowse link 2 189,840,403 189,857,032 RGD:628585
increased systemic arterial systolic blood pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Add1 adducin 1 JBrowse link 14 81,367,466 81,426,610 RGD:1302895
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 JBrowse link 10 59,528,849 59,560,440 RGD:68726
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:69709
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:1581830
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:11251783
G Gch1 GTP cyclohydrolase 1 JBrowse link 15 23,935,011 23,968,971 RGD:1601283
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:13432147
G Leprfa leptin receptor; fa mutant RGD:13432147
increased vasodilation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1580452
increased ventricle muscle contractility term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 JBrowse link 1 131,447,671 131,465,749 RGD:10401852
G Nr2f2em1Mcwi nuclear receptor subfamily 2, group F, member 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:10401852
pathological neovascularization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1580975
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292014
prolonged QT interval term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:12910116
pulmonary hypertension term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1578336
salt-sensitive hypertension term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Astn1 astrotactin 1 JBrowse link 13 76,054,965 76,370,674 RGD:12792227
G Brinp2 BMP/retinoic acid inducible neural specific 2 JBrowse link 13 75,948,679 76,049,363 RGD:12792227
G Btg2 BTG anti-proliferation factor 2 JBrowse link 13 50,913,185 50,916,944 RGD:12802368
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:12802369
G Chit1 chitinase 1 JBrowse link 13 50,947,020 50,994,644 RGD:12802369
G Etnk2 ethanolamine kinase 2 JBrowse link 13 50,481,178 50,498,991 RGD:12802369
G Fmod fibromodulin JBrowse link 13 50,874,886 50,885,503 RGD:12802368
G Gpr37l1 G protein-coupled receptor 37-like 1 JBrowse link 13 51,985,698 51,992,547 RGD:12802369
G Ipo9 importin 9 JBrowse link 13 52,203,384 52,256,196 RGD:12802369
G Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 JBrowse link 13 51,811,904 51,931,193 RGD:12802369
G LOC304754 similar to Proteasome activator complex subunit 2 (Proteasome activator 28-beta subunit) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex beta subunit) (REG-beta) JBrowse link 13 43,079,512 43,080,402 RGD:12798539
G Mgat5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase JBrowse link 13 43,850,744 44,157,860 RGD:12798539
G Mybph myosin binding protein H JBrowse link 13 51,034,228 51,041,903 RGD:12802369
G Nckap5 NCK-associated protein 5 JBrowse link 13 42,265,875 43,049,232 RGD:12798539
G Optc opticin JBrowse link 13 50,735,509 50,748,908 RGD:12802368
G Pappa2 pappalysin 2 JBrowse link 13 76,389,150 76,660,248 RGD:12792227
G Plekha6 pleckstrin homology domain containing A6 JBrowse link 13 50,555,454 50,582,236 RGD:12802369
G Prelp proline and arginine rich end leucine rich repeat protein JBrowse link 13 50,749,526 50,773,934 RGD:12802368
G Ptprv protein tyrosine phosphatase, receptor type, V JBrowse link 13 51,935,239 51,956,262 RGD:12802369
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:12802368
G Rfwd2 ring finger and WD repeat domain 2 JBrowse link 13 76,942,883 77,076,015 RGD:12792227
G RGD1560333 similar to Ferritin light chain (Ferritin L subunit) JBrowse link 13 43,384,999 43,385,544 RGD:12798539
G RGD1563709 similar to K-ALPHA-1 protein JBrowse link 13 43,401,273 43,402,677 RGD:12798539
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:12802369
G Sox13 SRY box 13 JBrowse link 13 50,434,702 50,479,118 RGD:12802369
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:12802369
G Tmem163 transmembrane protein 163 JBrowse link 13 44,166,306 44,345,735 RGD:12798539
G Tnr tenascin R JBrowse link 13 77,602,249 77,678,385 RGD:12792227
shortened QT interval term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:13442502
thin ventricular wall term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 JBrowse link 1 35,067,268 35,200,530 RGD:9685162
G Adamts16em1Bj ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj RGD:9685162
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:11565821
G Ttnem2Sage Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs RGD:11565821
vascular smooth muscle hypertrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:1642674
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642674

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  mammalian phenotype 4969
    cardiovascular system phenotype 1240
      abnormal cardiovascular system morphology + 312
      abnormal cardiovascular system physiology + 1034
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