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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:impaired natural killer cell mediated cytotoxicity
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Accession:MP:0005070 term browser browse the term
Definition:impaired ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors
Synonyms:exact_synonym: defective NK cell cytolysis;   defective natural killer cell cytolysis;   impaired NK cell cytolysis;   impaired NK cell mediated cell death;   impaired NK cell mediated cell killing;   impaired NK cell mediated cytolysis;   impaired NK cell mediated cytotoxicity;   impaired natural killer cell mediated cell death;   impaired natural killer cell mediated cell killing;   impaired natural killer cell mediated cytolysis
 broad_synonym: impaired killer activity


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impaired natural killer cell mediated cytotoxicity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp4 dipeptidylpeptidase 4 IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Dpp4DPPIV dipeptidylpeptidase 4; DPPIV mutant IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal innate immunity 24
          abnormal NK cell physiology 5
            abnormal natural killer cell mediated cytotoxicity 5
              impaired natural killer cell mediated cytotoxicity 5
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal adaptive immunity 60
          abnormal leukocyte physiology 56
            abnormal lymphocyte physiology 49
              abnormal NK cell physiology 5
                abnormal natural killer cell mediated cytotoxicity 5
                  impaired natural killer cell mediated cytotoxicity 5
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