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ONTOLOGY REPORT - ANNOTATIONS

Term:Ire1 complex
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Accession:GO:1990332 term browser browse the term
Definition:A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
Comment:An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay).
Synonyms:exact_synonym: IRE1 dimer
 related_synonym: ERN1 complex


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  cellular_component 21254
    protein-containing complex 6911
      membrane protein complex 1445
        Ire1 complex 0
Path 2
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  cellular_component 21254
    cellular anatomical entity 21098
      organelle 14217
        intracellular organelle 13782
          intracellular membrane-bounded organelle 12228
            endoplasmic reticulum 1905
              endoplasmic reticulum subcompartment 1063
                endoplasmic reticulum membrane 1053
                  Ire1 complex 0
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