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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of mitochondrial membrane permeability involved in apoptotic process
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Accession:GO:1902110 term browser browse the term
Definition:Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process.
Comment:Individual components of the mitochondrial permeability transition pore complex, such as the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D), are involved in this process.
Synonyms:exact_synonym: positive regulation of mitochondrial membrane permeability involved in apoptotic cell death;   positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death;   positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis;   positive regulation of transport across mitochondrial membrane involved in apoptotic cell death;   positive regulation of transport across mitochondrial membrane involved in apoptotic process;   positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis
 narrow_synonym: mitochondrial membrane permeability transition involved in apoptosis;   mitochondrial membrane permeability transition involved in apoptotic cell death;   mitochondrial membrane permeability transition involved in apoptotic process;   mitochondrial membrane permeability transition involved in apoptotic program;   mitochondrial membrane permeability transition involved in apoptotic programmed cell death;   mitochondrial membrane permeability transition involved in programmed cell death by apoptosis;   mitochondrial membrane permeability transition involved in type I programmed cell death;   mitochondrial membrane permeabilization involved in apoptosis;   mitochondrial membrane permeabilization involved in apoptotic cell death;   mitochondrial membrane permeabilization involved in apoptotic process;   mitochondrial membrane permeabilization involved in apoptotic program;   mitochondrial membrane permeabilization involved in apoptotic programmed cell death;   mitochondrial membrane permeabilization involved in programmed cell death by apoptosis;   mitochondrial membrane permeabilization involved in type I programmed cell death;   mitochondrial permeability transition involved in apoptosis;   mitochondrial permeability transition involved in apoptotic cell death;   mitochondrial permeability transition involved in apoptotic process;   mitochondrial permeability transition involved in apoptotic program;   mitochondrial permeability transition involved in apoptotic programmed cell death;   mitochondrial permeability transition involved in programmed cell death by apoptosis;   mitochondrial permeability transition involved in type I programmed cell death;   positive regulation of mitochondrial membrane permeability involved in apoptosis;   positive regulation of mitochondrial membrane permeability involved in apoptotic program;   positive regulation of mitochondrial membrane permeability involved in type I programmed cell death;   positive regulation of transport across mitochondrial membrane involved in apoptosis;   positive regulation of transport across mitochondrial membrane involved in apoptotic program;   positive regulation of transport across mitochondrial membrane involved in type I programmed cell death
 related_synonym: mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity;   mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity;   mitochondrial permeability transition involved in signaling (initiator) caspase activity;   positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity;   positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity



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positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
ISS
IEA
(PMID:22304920)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:22304920 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1197519 (MGI:3581932|PMID:15967824) RGD PMID:15967824 MGI:3581932 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:99702 (MGI:3581932|PMID:15967824) RGD PMID:15967824 MGI:3581932 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456
JBrowse link
G Stpg1 sperm-tail PG-rich repeat containing 1 involved_in ISO
IBA
(PMID:23028632)
GO_REF:0000033
RGD
GO_Central
PMID:23028632 GO_REF:0000033 NCBI chr 5:147,717,084...147,769,792
Ensembl chr 5:147,726,646...147,769,788
JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07067600.1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 9:48,763,742...48,764,305 JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:1929260 (MGI:5566519|PMID:20436477)
GO_REF:0000107
RGD
Ensembl
PMID:20436477 GO_REF:0000107 MGI:5566519 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 involved_in ISO
IEA
ISS
(PMID:18188704)
GO_REF:0000107
RGD
Ensembl
PMID:18188704 PMID:18188704 GO_REF:0000107, RGD:8553738 NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653
JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO
IBA
(PMID:18371312)
GO_REF:0000033
RGD
GO_Central
PMID:18371312 GO_REF:0000033 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3-ps3 BCL2 interacting protein 3, pseudogene 3 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr  X:41,782,256...41,782,924
Ensembl chr  X:41,782,209...41,782,898
Ensembl chr  X:41,782,209...41,782,898
JBrowse link
G Bnip3l BCL2 interacting protein 3 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G ENSRNOG00000066967 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 8:96,464,314...96,465,381 JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (MGI:2158099|PMID:11700312) RGD PMID:11700312 MGI:2158099 NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793
JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO (PMID:12482879) RGD PMID:12482879 NCBI chr10:65,198,700...65,262,807
Ensembl chr10:65,170,560...65,262,804
JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISS
ISO
GO_REF:0000024
(PMID:12482879)
UniProt
RGD
PMID:12482879 GO_REF:0000024 NCBI chr10:14,858,954...14,864,751
Ensembl chr10:14,858,956...14,864,751
JBrowse link
G Vdac2 voltage-dependent anion channel 2 involved_in ISO
ISS
(PMID:31015432)
GO_REF:0000024
RGD
UniProt
PMID:31015432 GO_REF:0000024 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:18371312)
Ensembl
UniProt
RGD
PMID:18371312 GO_REF:0000024 GO_REF:0000107 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:15901672) RGD PMID:15901672 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:15901672), (PMID:9393856)
GO_REF:0000114
RGD
ComplexPortal
PMID:9393856 PMID:15901672 GO_REF:0000114 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G ENSRNOG00000063076 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 7:88,803,047...88,804,403 JBrowse link
G ENSRNOG00000063289 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr10:100,153,638...100,154,558 JBrowse link
G ENSRNOG00000066174 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:201,787,072...201,792,824 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:104995 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (MGI:4437986|PMID:19096392) RGD PMID:19096392 MGI:4437986 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649
JBrowse link
G Slc25a31 solute carrier family 25 member 31 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795
JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:19154410)
UniProt
GO_Central
RGD
PMID:19154410 GO_REF:0000024 GO_REF:0000033 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Slc25a5-ps9 solute carrier family 25 member 5, pseudogene 9 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 3:96,656,145...96,657,368
Ensembl chr 3:96,656,151...96,657,400
JBrowse link
G Slc25a6 solute carrier family 25 member 6 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199
JBrowse link
G Slc35f6 solute carrier family 35, member F6 involved_in ISS
ISO
GO_REF:0000024
(PMID:19154410)
UniProt
RGD
PMID:19154410 GO_REF:0000024 NCBI chr 6:25,725,822...25,737,720
Ensembl chr 6:25,725,819...25,737,730
JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO (PMID:21723035) RGD PMID:21723035 NCBI chr 9:23,640,594...23,652,379
Ensembl chr 9:23,733,039...23,734,463
Ensembl chr 9:23,733,039...23,734,463
JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (MGI:4437986|PMID:19096392) RGD PMID:19096392 MGI:4437986 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
GO_REF:0000024
(MGI:5796067|PMID:26949185)
UniProt
RGD
PMID:26949185 GO_REF:0000024 MGI:5796067 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) RGD PMID:26666268 PMID:30092269 NCBI chr20:12,725,839...12,727,638
Ensembl chr20:12,725,842...12,732,763
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5514334|PMID:16543145)
UniProt
Ensembl
RGD
PMID:16543145 GO_REF:0000024 GO_REF:0000107 MGI:5514334 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
ISO
GO_REF:0000024
(MGI:5514334|PMID:16543145)
UniProt
RGD
PMID:16543145 GO_REF:0000024 MGI:5514334 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO UniProtKB:Q9HD36 (PMID:19255499) RGD PMID:19255499 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO (PMID:15034012) RGD PMID:15034012 NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615
JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:18591963) RGD PMID:18591963 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863
JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO (PMID:17828305) RGD PMID:17828305 NCBI chr10:54,523,901...54,525,997
Ensembl chr10:54,523,585...54,525,990
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18766
      cell death 2197
        programmed cell death 2197
          mitochondrial outer membrane permeabilization involved in programmed cell death 48
            positive regulation of mitochondrial membrane permeability involved in apoptotic process 46
              mitochondrial outer membrane permeabilization + 39
Path 2
Term Annotations click to browse term
  biological_process 20292
    cellular process 18766
      cellular component organization or biogenesis 7192
        cellular component organization 6884
          organelle organization 3827
            mitochondrion organization 571
              mitochondrial membrane organization 126
                regulation of mitochondrial membrane permeability 67
                  positive regulation of mitochondrial membrane permeability 51
                    mitochondrial outer membrane permeabilization involved in programmed cell death 48
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 46
                        mitochondrial outer membrane permeabilization + 39
paths to the root