ONTOLOGY REPORT - ANNOTATIONS
Term: HCN channel complex
Accession: GO:0098855
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Definition: A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart.
Synonyms: exact_synonym: K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex
narrow_synonym: HCN1 channel complex; HCN2 channel complex; HCN3 channel complex; HCN4 channel complex; K/Na hyperpolarization-activated channel 3 complex; K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex; K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex; K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex; potassium/sodium hyperpolarization-activated channel 3 complex; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex
related_synonym: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer
alt_id: GO:1990746; GO:1990759
G
Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
part_of
ISO ISS IEA IBA
(PMID:28086084) GO_REF:0000024 GO_REF:0000107 GO_REF:0000033
RGD UniProt Ensembl GO_Central
PMID:28086084
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774
G
Hcn2
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
part_of
ISO IEA IBA
(PMID:10228147) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:10228147
GO_REF:0000033 GO_REF:0000107
NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841
G
Hcn3
hyperpolarization-activated cyclic nucleotide-gated potassium channel 3
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:174,551,861...174,567,459
Ensembl chr 2:174,551,680...174,565,966
G
Hcn4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
part_of
ISO IEA IBA
(PMID:10228147), (PMID:16407510) GO_REF:0000107 GO_REF:0000033 GO_REF:0000118
RGD Ensembl GO_Central TreeGrafter
PMID:10228147 PMID:16407510
GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639
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