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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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Accession:GO:0097199 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.
Comment:Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases.
Synonyms:exact_synonym: cysteine-type endopeptidase activity involved in apoptotic signalling pathway
 narrow_synonym: activator caspase activity;   apical caspase activity;   initiator caspase activity


show annotations for term's descendants           Sort by:
cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:16920334), (PMID:21980415)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:16920334 PMID:21980415 GO_REF:0000024 GO_REF:0000033 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 enables ISO
IBA		 (PMID:11717445), (PMID:16916640), (PMID:16920334), (PMID:21980415)
GO_REF:0000033		 RGD
GO_Central		 PMID:11717445 PMID:16916640 PMID:16920334 PMID:21980415 GO_REF:0000033 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 enables ISO
IBA		 (PMID:16916640), (PMID:16920334), (PMID:21980415)
GO_REF:0000033		 RGD
GO_Central		 PMID:16916640 PMID:16920334 PMID:21980415 GO_REF:0000033 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Casp9_v1 caspase-9-carboxyl-terminal divergent enables IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Cflar CASP8 and FADD-like apoptosis regulator enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      hydrolase activity 2639
        peptidase activity 704
          endopeptidase activity 475
            cysteine-type endopeptidase activity 90
              cysteine-type endopeptidase activity involved in apoptotic process 10
                cysteine-type endopeptidase activity involved in apoptotic signaling pathway 6
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