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ONTOLOGY REPORT - ANNOTATIONS


Term:NAADP-sensitive calcium-release channel activity
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Accession:GO:0072345 term browser browse the term
Definition:Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts.
Synonyms:xref: reactome:R-HSA-2685505 "TPCN1/2 transport lysosomal Ca2+ to cytosol"



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NAADP-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcoln1 mucolipin TRP cation channel 1 enables IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:17613490 GO_REF:0000033, RGD:7205504 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252
JBrowse link
G Mcoln2 mucolipin TRP cation channel 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:235,053,816...235,102,703
Ensembl chr 2:235,053,816...235,102,702
JBrowse link
G Mcoln3 mucolipin TRP cation channel 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:235,008,716...235,042,885
Ensembl chr 2:234,966,010...235,043,047
JBrowse link
G Tpcn1 two pore segment channel 1 enables
NOT|enables
ISO
IEA
ISS
(PMID:19620632)
GO_REF:0000107
(PMID:24776928)
(MGI:6718238|PMID:24776928)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19620632 PMID:24776928 GO_REF:0000024 GO_REF:0000107 MGI:6718238 NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626
JBrowse link
G Tpcn2 two pore segment channel 2 enables
NOT|enables
ISO (PMID:19387438), (PMID:19620632), (PMID:20880839), (PMID:32167471)
(PMID:23063126)
(MGI:5285159|PMID:20495006), (MGI:5285171|PMID:19557428), (MGI:5691857|PMID:25144390)
RGD PMID:19387438 PMID:19557428 PMID:19620632 PMID:20495006 PMID:20880839 More... MGI:5285159 MGI:5285171 MGI:5691857 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        monoatomic ion transmembrane transporter activity 752
          monoatomic ion channel activity 457
            ligand-gated monoatomic ion channel activity 183
              intracellularly ligand-gated monoatomic ion channel activity 32
                intracellularly gated calcium channel activity 18
                  NAADP-sensitive calcium-release channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        passive transmembrane transporter activity 519
          channel activity 519
            gated channel activity 332
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 183
                  ligand-gated monoatomic cation channel activity 129
                    ligand-gated calcium channel activity 33
                      intracellularly gated calcium channel activity 18
                        NAADP-sensitive calcium-release channel activity 5
paths to the root