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ONTOLOGY REPORT - ANNOTATIONS

Term:Ragulator complex
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Accession:GO:0071986 term browser browse the term
Definition:A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).
Synonyms:exact_synonym: MAPKSP1/ROBLD3/C11orf59 complex;   Rag GEF
 related_synonym: EGO complex;   EGO-GSE complex;   GSE complex;   GTPase-containing complex for Gap1p sorting in the endosome
 alt_id: GO:0034448;   GO:0034449


show annotations for term's descendants           Sort by:
Ragulator complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000066475 part_of IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 7:1,169,039...1,178,734 JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 part_of
located_in
is_active_in		 ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:28935770)
GO_REF:0000002
(PMID:20381137), (PMID:29158492), (PMID:31601708)
(PMID:28935770), (PMID:29123114)
GO_REF:0000118
GO_REF:0000033		 UniProt
RGD
InterPro
TreeGrafter
GO_Central		 PMID:20381137 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179 		JBrowse link
G Lamtor1l1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 part_of ISS
IEA
IBA		 GO_REF:0000024
GO_REF:0000002
GO_REF:0000118
GO_REF:0000033		 UniProt
InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:34,637,460...34,638,509
Ensembl chr  X:34,637,459...34,638,516 		JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 located_in
part_of		 ISO
IBA		 (PMID:28935770)
(PMID:20381137), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)
GO_REF:0000033		 RGD
GO_Central		 PMID:20381137 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000033 NCBI chr 2:174,008,556...174,011,950
Ensembl chr 2:174,008,548...174,013,013 		JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 part_of
located_in		 ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:28935770)
GO_REF:0000107
(PMID:20381137), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:20381137 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607 		JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 located_in
part_of		 ISO
IBA		 (PMID:28935770)
(PMID:22980980), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)
GO_REF:0000033		 RGD
GO_Central		 PMID:22980980 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000033 NCBI chr12:17,258,656...17,262,478
Ensembl chr12:17,258,623...17,262,480 		JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 located_in
part_of		 ISO
IBA		 (PMID:28935770)
(PMID:22980980), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)
GO_REF:0000033		 RGD
GO_Central		 PMID:22980980 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000033 NCBI chr 2:194,900,038...194,905,394
Ensembl chr 2:194,900,038...194,905,395 		JBrowse link
G Slc38a9 solute carrier family 38, member 9 located_in ISS
ISO		 GO_REF:0000024
(PMID:25561175), (PMID:25567906)		 UniProt
RGD		 PMID:25561175 PMID:25567906 GO_REF:0000024 NCBI chr 2:44,291,637...44,374,897
Ensembl chr 2:44,291,989...44,368,955 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      membrane protein complex 1451
        Ragulator complex 8
Path 2
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      organelle 14344
        intracellular organelle 13898
          intracellular membrane-bounded organelle 12331
            vacuole 671
              vacuolar membrane 362
                Ragulator complex 8
paths to the root