ONTOLOGY REPORT - ANNOTATIONS

Term:ERK1 and ERK2 cascade
go back to main search page
Accession:GO:0070371 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Comment:Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
Synonyms:exact_synonym: ERK1 and ERK2 signaling pathway;   ERK1 and ERK2 signalling pathway;   ERK1/2 cascade;   extracellular signal-regulated kinase 1/2 (ERK1/2) cascade;   extracellular signal-regulated kinase 1/2 cascade
 narrow_synonym: ERK1 cascade;   ERK2 cascade;   MAPK1 cascade;   MAPK3 cascade
 broad_synonym: ERK cascade
 xref_analog: Reactome:REACT_100214;   Reactome:REACT_102658;   Reactome:REACT_107705;   Reactome:REACT_110773;   Reactome:REACT_111031;   Reactome:REACT_112775;   Reactome:REACT_112819;   Reactome:REACT_115367;   Reactome:REACT_1183;   Reactome:REACT_25141;   Reactome:REACT_25393;   Reactome:REACT_29696;   Reactome:REACT_77794;   Reactome:REACT_77829;   Reactome:REACT_81711;   Reactome:REACT_90463;   Reactome:REACT_94688;   Reactome:REACT_97178;   Reactome:REACT_97662

  • Rat
  • Mouse
  • Human
  • All
  • show annotations for term's descendants
  •     Sort by:
ERK1 and ERK2 cascade term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link IDA 19 54,738,556 54,750,349 RGD:5129174 RGD
G Avp arginine vasopressin GBrowse link ISO 3 118,205,007 118,206,985 RGD:1624291 RGD
G Avp arginine vasopressin GBrowse link IEA 3 118,205,007 118,206,985 RGD:1600115 ENSEMBL
G Cckbr cholecystokinin B receptor GBrowse link IMP 1 163,156,914 163,166,969 RGD:2311329 RGD
G Ccl11 chemokine (C-C motif) ligand 11 GBrowse link IGI 10 70,279,161 70,283,762 RGD:4145648 RGD
G Ccr3 chemokine (C-C motif) receptor 3 GBrowse link IGI 8 128,759,943 128,769,341 RGD:4145648 RGD
G Ctsh cathepsin H GBrowse link ISO 8 94,971,689 94,990,434 RGD:1624291 RGD
G Ctsh cathepsin H GBrowse link ISS 8 94,971,689 94,990,434 RGD:1600115 UniProtKB
G Egf epidermal growth factor GBrowse link ISO 2 227,103,900 227,195,062 RGD:1624291 RGD
G Fgf10 fibroblast growth factor 10 GBrowse link ISO 2 50,866,799 50,940,319 RGD:1624291 RGD
G Fgf10 fibroblast growth factor 10 GBrowse link IEA 2 50,866,799 50,940,319 RGD:1600115 ENSEMBL
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled GBrowse link ISO 15 55,463,743 55,532,293 RGD:1624291 RGD
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled GBrowse link IEA 15 55,463,743 55,532,293 RGD:1600115 ENSEMBL
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link ISO 9 84,840,026 84,852,984 RGD:1624291 RGD
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link ISO 9 84,840,026 84,852,984 RGD:1624291 RGD
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link ISO 9 84,840,026 84,852,984 RGD:1624291 RGD
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link ISO 9 84,840,026 84,852,984 RGD:1624291 RGD
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link IEA 9 84,840,026 84,852,984 RGD:1600115 ENSEMBL
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link IEA 9 84,840,026 84,852,984 RGD:1600115 ENSEMBL
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link ISS 9 84,840,026 84,852,984 RGD:1600115 UniProtKB
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled GBrowse link ISS 9 84,840,026 84,852,984 RGD:1600115 UniProtKB
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled GBrowse link ISO X 31,012,921 31,244,127 RGD:1624291 RGD
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled GBrowse link IEA X 31,012,921 31,244,127 RGD:1600115 ENSEMBL
G Iqgap3 IQ motif containing GTPase activating protein 3 GBrowse link ISO 2 180,155,679 180,198,814 RGD:1624291 RGD
G Iqgap3 IQ motif containing GTPase activating protein 3 GBrowse link IEA 2 180,155,679 180,198,814 RGD:1600115 ENSEMBL
G Itgav integrin, alpha V GBrowse link ISO 3 66,953,403 67,029,774 RGD:1624291 RGD
G Mapk1 mitogen activated protein kinase 1 GBrowse link ISO 11 85,968,732 86,030,387 RGD:1624291 RGD
G Mapk1 mitogen activated protein kinase 1 GBrowse link IEA 11 85,968,732 86,030,387 RGD:1600115 ENSEMBL
G Med1 mediator complex subunit 1 GBrowse link IEA 10 86,917,525 86,959,080 RGD:1600115 ENSEMBL
G Med1 mediator complex subunit 1 GBrowse link ISO 10 86,917,525 86,959,080 RGD:1624291 RGD
G Mt3 metallothionein 3 GBrowse link ISO 19 11,284,554 11,286,402 RGD:1624291 RGD
G Mt3 metallothionein 3 GBrowse link ISS 19 11,284,554 11,286,402 RGD:1600115 UniProtKB
G Oxtr oxytocin receptor GBrowse link IMP 4 148,314,089 148,326,797 RGD:2304226 RGD
G Ptger4 prostaglandin E receptor 4 (subtype EP4) GBrowse link IDA 2 54,423,280 54,433,907 UniProtKB
G Sox9 SRY (sex determining region Y)-box 9 GBrowse link IDA 10 102,392,187 102,394,256 RGD:2290270 UniProtKB
G Sox9 SRY (sex determining region Y)-box 9 GBrowse link ISS 10 102,392,187 102,394,256 RGD:1600115 UniProtKB
G Sox9 SRY (sex determining region Y)-box 9 GBrowse link ISO 10 102,392,187 102,394,256 RGD:1624291 RGD
G Tf transferrin GBrowse link ISO 8 108,217,774 108,244,487 RGD:1624291 RGD
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 GBrowse link ISO 15 59,397,837 59,428,014 RGD:1624291 RGD
negative regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link ISO 11 79,908,291 79,911,065 RGD:1624291 RGD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link ISS 11 79,908,291 79,911,065 RGD:1600115 UniProtKB
G Ankrd26 ankyrin repeat domain 26 GBrowse link ISO 4 154,801,803 154,871,524 RGD:1624291 RGD
G Arrb1 arrestin, beta 1 GBrowse link IMP 1 156,871,564 156,937,540 RGD:5509898 RGD
G Cav1 caveolin 1, caveolae protein GBrowse link IDA 4 42,956,102 42,989,057 RGD:6849300 RGD
G Cnksr3 Cnksr family member 3 GBrowse link ISO 1 37,865,904 37,958,862 RGD:1624291 RGD
G Cnksr3 Cnksr family member 3 GBrowse link ISS 1 37,865,904 37,958,862 RGD:1600115 UniProtKB
G Csk c-src tyrosine kinase GBrowse link IDA 8 61,381,336 61,386,013 RGD:2303720 RGD
G Dab2 disabled 2, mitogen-responsive phosphoprotein GBrowse link IDA 2 55,714,874 55,736,370 UniProtKB
G Dab2ip DAB2 interacting protein GBrowse link ISO 3 14,667,700 14,840,625 RGD:1624291 RGD
G Dab2ip DAB2 interacting protein GBrowse link ISS 3 14,667,700 14,840,625 RGD:1600115 UniProtKB
G Dusp3 dual specificity phosphatase 3 GBrowse link ISO 10 91,031,206 91,044,858 RGD:1624291 RGD
G Dusp3 dual specificity phosphatase 3 GBrowse link IBA 10 91,031,206 91,044,858 RGD:1600115 RefGenome
G Dusp6 dual specificity phosphatase 6 GBrowse link IDA 7 36,893,264 36,897,494 RGD:728656 RGD
G Dusp6 dual specificity phosphatase 6 GBrowse link ISO 7 36,893,264 36,897,494 RGD:1624291 RGD
G Flcn folliculin GBrowse link ISO 10 46,110,527 46,129,613 RGD:1624291 RGD
G Flcn folliculin GBrowse link ISO 10 46,110,527 46,129,613 RGD:1624291 RGD
G Flcn folliculin GBrowse link ISS 10 46,110,527 46,129,613 RGD:1600115 UniProtKB
G Gstp1 glutathione S-transferase pi 1 GBrowse link ISO 1 206,627,398 206,629,866 RGD:1624291 RGD
G Gstp1 glutathione S-transferase pi 1 GBrowse link ISO 1 206,627,398 206,629,866 RGD:1624291 RGD
G Gstp1 glutathione S-transferase pi 1 GBrowse link ISS 1 206,627,398 206,629,866 RGD:1600115 BHF-UCL
G Igf1 insulin-like growth factor 1 GBrowse link ISO 7 24,531,669 24,605,742 RGD:1624291 RGD
G Igf1 insulin-like growth factor 1 GBrowse link IEA 7 24,531,669 24,605,742 RGD:1600115 ENSEMBL
G Itgb1bp1 integrin beta 1 binding protein 1 GBrowse link ISO 6 41,830,110 41,844,514 RGD:1624291 RGD
G Klf4 Kruppel-like factor 4 (gut) GBrowse link IMP 5 73,446,928 73,451,286 UniProtKB
G Lif leukemia inhibitory factor GBrowse link ISO 14 84,887,856 84,890,630 RGD:1624291 RGD
G Lif leukemia inhibitory factor GBrowse link IEA 14 84,887,856 84,890,630 RGD:1600115 ENSEMBL
G LOC364561 similar to PIN1-like protein GBrowse link IEA 16 32,656,303 32,658,333 RGD:1600115 ENSEMBL
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISO 5 16,933,111 17,054,564 RGD:1624291 RGD
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISO 5 16,933,111 17,054,564 RGD:1624291 RGD
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISS 5 16,933,111 17,054,564 RGD:1600115 UniProtKB
G Ndrg2 NDRG family member 2 GBrowse link ISO 15 27,338,552 27,347,196 RGD:1624291 RGD
G Ndrg2 NDRG family member 2 GBrowse link IEA 15 27,338,552 27,347,196 RGD:1600115 ENSEMBL
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 GBrowse link ISO 8 19,669,537 19,681,741 RGD:1624291 RGD
G Rgs14 regulator of G-protein signaling 14 GBrowse link IDA 17 15,293,100 15,307,162 UniProtKB
G Rps6ka6 ribosomal protein S6 kinase polypeptide 6 GBrowse link ISO X 99,798,274 99,901,585 RGD:1624291 RGD
G Slc9a3r1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 GBrowse link ISO 10 105,237,637 105,254,750 RGD:1624291 RGD
G Slc9a3r1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 GBrowse link IEA 10 105,237,637 105,254,750 RGD:1600115 ENSEMBL
G Spry1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) GBrowse link IEA 2 124,213,692 124,218,334 RGD:1600115 ENSEMBL
G Spry2 sprouty homolog 2 (Drosophila) GBrowse link ISO 15 90,009,109 90,011,940 RGD:1624291 RGD
G Spry2 sprouty homolog 2 (Drosophila) GBrowse link IEA 15 90,009,109 90,011,940 RGD:1600115 ENSEMBL
G Tlr4 toll-like receptor 4 GBrowse link ISO 5 83,564,100 83,577,735 RGD:1624291 RGD
G Tlr4 toll-like receptor 4 GBrowse link IEA 5 83,564,100 83,577,735 RGD:1600115 ENSEMBL
G Tnip1 TNFAIP3 interacting protein 1 GBrowse link IEA 10 40,319,735 40,366,764 RGD:1600115 ENSEMBL
G Tnip1 TNFAIP3 interacting protein 1 GBrowse link ISO 10 40,319,735 40,366,764 RGD:1624291 RGD
G Vrk3 vaccinia related kinase 3 GBrowse link ISO 1 95,231,170 95,258,496 RGD:1624291 RGD
G Vrk3 vaccinia related kinase 3 GBrowse link IEA 1 95,231,170 95,258,496 RGD:1600115 ENSEMBL
G Wnk2 WNK lysine deficient protein kinase 2 GBrowse link IEA 17 21,461,980 21,600,361 RGD:1600115 ENSEMBL
G Wnk2 WNK lysine deficient protein kinase 2 GBrowse link ISO 17 21,461,980 21,600,361 RGD:1624291 RGD
positive regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adra1a adrenoceptor alpha 1A GBrowse link IMP 15 46,173,429 46,263,198 RGD:5688340 BHF-UCL
G Angpt1 angiopoietin 1 GBrowse link ISO 7 78,195,504 78,451,471 RGD:1624291 RGD
G Angpt1 angiopoietin 1 GBrowse link ISO 7 78,195,504 78,451,471 RGD:1624291 RGD
G Arhgap8 Rho GTPase activating protein 8 GBrowse link ISO 7 122,730,224 122,794,430 RGD:1624291 RGD
G Arrb1 arrestin, beta 1 GBrowse link ISO 1 156,871,564 156,937,540 RGD:1624291 RGD
G Arrb1 arrestin, beta 1 GBrowse link ISO 1 156,871,564 156,937,540 RGD:1624291 RGD
G Arrb1 arrestin, beta 1 GBrowse link IMP 1 156,871,564 156,937,540 RGD:5509998 RGD
G Arrb2 arrestin, beta 2 GBrowse link ISO 10 57,244,071 57,284,166 RGD:1624291 RGD
G Arrb2 arrestin, beta 2 GBrowse link ISO 10 57,244,071 57,284,166 RGD:1624291 RGD
G Arrb2 arrestin, beta 2 GBrowse link IMP 10 57,244,071 57,284,166 RGD:5510006 RGD
G Bmp2 bone morphogenetic protein 2 GBrowse link IEA 3 121,372,692 121,381,236 RGD:1600115 ENSEMBL
G Bmp2 bone morphogenetic protein 2 GBrowse link ISO 3 121,372,692 121,381,236 RGD:1624291 RGD
G Bmp2 bone morphogenetic protein 2 GBrowse link ISO 3 121,372,692 121,381,236 RGD:1624291 RGD
G Bmp4 bone morphogenetic protein 4 GBrowse link ISO 15 22,283,171 22,286,757 RGD:1624291 RGD
G Bmp4 bone morphogenetic protein 4 GBrowse link IEA 15 22,283,171 22,286,757 RGD:1600115 ENSEMBL
G Bmper BMP-binding endothelial regulator GBrowse link ISO 8 22,975,570 23,096,066 RGD:1624291 RGD
G Braf v-raf murine sarcoma viral oncogene homolog B1 GBrowse link IMP 4 67,117,759 67,243,058 RGD:2315869 RGD
G Braf v-raf murine sarcoma viral oncogene homolog B1 GBrowse link ISO 4 67,117,759 67,243,058 RGD:1624291 RGD
G C1qtnf3 C1q and tumor necrosis factor related protein 3 GBrowse link IEA 2 60,303,261 60,325,510 RGD:1600115 ENSEMBL
G C1qtnf3 C1q and tumor necrosis factor related protein 3 GBrowse link ISO 2 60,303,261 60,325,510 RGD:1624291 RGD
G C3 complement component 3 IDA RGD:5129534 RGD
G C5ar1 complement component 5a receptor 1 ISO RGD:1624291 RGD
G C5ar1 complement component 5a receptor 1 ISS RGD:1600115 UniProtKB
G Camk2d calcium/calmodulin-dependent protein kinase II delta GBrowse link IMP 2 223,840,650 224,108,082 RGD:6907067 RGD
G Ccl19 chemokine (C-C motif) ligand 19 GBrowse link IEA 5 59,221,738 59,223,682 RGD:1600115 ENSEMBL
G Ccl19 chemokine (C-C motif) ligand 19 GBrowse link ISO 5 59,221,738 59,223,682 RGD:1624291 RGD
G Ccl21 chemokine (C-C motif) ligand 21 GBrowse link ISO 5 59,238,897 59,240,001 RGD:1624291 RGD
G Ccl21 chemokine (C-C motif) ligand 21 GBrowse link ISO 5 59,238,897 59,240,001 RGD:1624291 RGD
G Ccl21 chemokine (C-C motif) ligand 21 GBrowse link IEA 5 59,238,897 59,240,001 RGD:1600115 ENSEMBL
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link ISO 10 71,744,559 71,746,109 RGD:1624291 RGD
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link ISS 10 71,744,559 71,746,109 RGD:1600115 UniProtKB
G Ccr1 chemokine (C-C motif) receptor 1 GBrowse link ISO 8 128,693,658 128,699,213 RGD:1624291 RGD
G Cd44 Cd44 molecule GBrowse link ISO 3 88,022,962 88,110,352 RGD:1624291 RGD
G Cd44 Cd44 molecule GBrowse link ISO 3 88,022,962 88,110,352 RGD:1624291 RGD
G Cd44 Cd44 molecule GBrowse link IEA 3 88,022,962 88,110,352 RGD:1600115 ENSEMBL
G Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain GBrowse link ISO 18 56,756,511 56,765,711 RGD:1624291 RGD
G Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain GBrowse link ISO 18 56,756,511 56,765,711 RGD:1624291 RGD
G Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain GBrowse link ISO 18 56,756,511 56,765,711 RGD:1624291 RGD
G Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain GBrowse link ISS 18 56,756,511 56,765,711 RGD:1600115 BHF-UCL
G Chi3l1 chitinase 3-like 1 (cartilage glycoprotein-39) GBrowse link ISO 13 47,139,658 47,147,591 RGD:1624291 RGD
G Chi3l1 chitinase 3-like 1 (cartilage glycoprotein-39) GBrowse link ISS 13 47,139,658 47,147,591 RGD:1600115 UniProtKB
G Csf1r colony stimulating factor 1 receptor GBrowse link ISO 18 57,080,324 57,107,295 RGD:1624291 RGD
G Csf1r colony stimulating factor 1 receptor GBrowse link IEA 18 57,080,324 57,107,295 RGD:1600115 ENSEMBL
G Csf1r colony stimulating factor 1 receptor GBrowse link ISS 18 57,080,324 57,107,295 RGD:1600115 UniProtKB
G Ctgf connective tissue growth factor GBrowse link ISO 1 21,327,099 21,330,215 RGD:1624291 RGD
G Ctgf connective tissue growth factor GBrowse link IEA 1 21,327,099 21,330,215 RGD:1600115 ENSEMBL
G Cysltr2 cysteinyl leukotriene receptor 2 GBrowse link IMP 15 53,647,500 53,648,429 RGD:5144006 RGD
G Dcc deleted in colorectal carcinoma GBrowse link IMP 18 68,026,795 69,140,741 RGD:2314384 RGD
G Drd2 dopamine receptor D2 GBrowse link IMP 8 52,641,160 52,707,749 RGD:2311559 RGD
G Ednra endothelin receptor type A GBrowse link IMP 19 32,042,366 32,108,153 RGD:4892323 RGD
G Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) GBrowse link ISO 9 66,843,898 67,967,970 RGD:1624291 RGD
G Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) GBrowse link ISS 9 66,843,898 67,967,970 RGD:1600115 UniProtKB
G Esr1 estrogen receptor 1 GBrowse link IDA 1 35,523,680 35,759,891 RGD:5128669 RGD
G Esr2 estrogen receptor 2 (ER beta) GBrowse link IDA 6 98,691,167 98,775,299 RGD:5128669 RGD
G F2r coagulation factor II (thrombin) receptor GBrowse link ISO 2 25,985,800 25,989,072 RGD:1624291 RGD
G F2r coagulation factor II (thrombin) receptor GBrowse link ISS 2 25,985,800 25,989,072 RGD:1600115 UniProtKB
G F2rl1 coagulation factor II (thrombin) receptor-like 1 GBrowse link ISO 2 25,886,177 25,899,128 RGD:1624291 RGD
G F2rl1 coagulation factor II (thrombin) receptor-like 1 GBrowse link ISO 2 25,886,177 25,899,128 RGD:1624291 RGD
G F2rl1 coagulation factor II (thrombin) receptor-like 1 GBrowse link ISS 2 25,886,177 25,899,128 RGD:1600115 UniProtKB
G Fbxw7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase GBrowse link ISO 2 176,675,226 176,750,737 RGD:1624291 RGD
G Fgf10 fibroblast growth factor 10 GBrowse link ISO 2 50,866,799 50,940,319 RGD:1624291 RGD
G Fgf10 fibroblast growth factor 10 GBrowse link ISO 2 50,866,799 50,940,319 RGD:1624291 RGD
G Fgf10 fibroblast growth factor 10 GBrowse link ISO 2 50,866,799 50,940,319 RGD:1624291 RGD
G Fgf10 fibroblast growth factor 10 GBrowse link IEA 2 50,866,799 50,940,319 RGD:1600115 ENSEMBL
G Fgf18 fibroblast growth factor 18 ISO RGD:1624291 RGD
G Fgf18 fibroblast growth factor 18 IEA RGD:1600115 ENSEMBL
G Fgf19 fibroblast growth factor 19 GBrowse link ISO 1 205,324,890 205,328,178 RGD:1624291 RGD
G Fgf19 fibroblast growth factor 19 GBrowse link IEA 1 205,324,890 205,328,178 RGD:1600115 ENSEMBL
G Fgf2 fibroblast growth factor 2 GBrowse link ISO 2 123,893,314 123,947,136 RGD:1624291 RGD
G Fgf2 fibroblast growth factor 2 GBrowse link IEA 2 123,893,314 123,947,136 RGD:1600115 ENSEMBL
G Fgf20 fibroblast growth factor 20 GBrowse link IDA 16 55,386,987 55,393,744 MGI
G Fgf21 fibroblast growth factor 21 GBrowse link ISO 1 96,082,475 96,083,718 RGD:1624291 RGD
G Fgf21 fibroblast growth factor 21 GBrowse link IEA 1 96,082,475 96,083,718 RGD:1600115 ENSEMBL
G Fgf23 fibroblast growth factor 23 GBrowse link ISO 4 163,468,604 163,476,325 RGD:1624291 RGD
G Fgf23 fibroblast growth factor 23 GBrowse link IEA 4 163,468,604 163,476,325 RGD:1600115 ENSEMBL
G Fgf4 fibroblast growth factor 4 GBrowse link ISO 1 205,292,272 205,293,705 RGD:1624291 RGD
G Fgfr2 fibroblast growth factor receptor 2 GBrowse link ISO 1 189,482,975 189,589,279 RGD:1624291 RGD
G Fgfr2 fibroblast growth factor receptor 2 GBrowse link IEA 1 189,482,975 189,589,279 RGD:1600115 ENSEMBL
G Fgfr3 fibroblast growth factor receptor 3 GBrowse link ISO 14 82,683,191 82,697,229 RGD:1624291 RGD
G Fgfr3 fibroblast growth factor receptor 3 GBrowse link IEA 14 82,683,191 82,697,229 RGD:1600115 ENSEMBL
G Fgfr4 fibroblast growth factor receptor 4 GBrowse link ISO 17 15,512,144 15,527,348 RGD:1624291 RGD
G Fgfr4 fibroblast growth factor receptor 4 GBrowse link ISS 17 15,512,144 15,527,348 RGD:1600115 UniProtKB
G Flt4 fms-related tyrosine kinase 4 GBrowse link ISO 10 35,071,002 35,112,006 RGD:1624291 RGD
G Flt4 fms-related tyrosine kinase 4 GBrowse link IEA 10 35,071,002 35,112,006 RGD:1600115 ENSEMBL
G Gas6 growth arrest specific 6 GBrowse link ISO 16 80,900,159 80,930,929 RGD:1624291 RGD
G Gas6 growth arrest specific 6 GBrowse link IEA 16 80,900,159 80,930,929 RGD:1600115 ENSEMBL
G Gcg glucagon GBrowse link ISO 3 44,433,180 44,438,004 RGD:1624291 RGD
G Gcg glucagon GBrowse link IEA 3 44,433,180 44,438,004 RGD:1600115 ENSEMBL
G Gper G protein-coupled estrogen receptor 1 GBrowse link IDA 12 15,718,615 15,719,893 RGD:4892081 RGD
G Gper G protein-coupled estrogen receptor 1 GBrowse link IDA 12 15,718,615 15,719,893 RGD:4892084 RGD
G Gpr183 G protein-coupled receptor 183 GBrowse link ISO 15 107,056,367 107,067,887 RGD:1624291 RGD
G Gpr183 G protein-coupled receptor 183 GBrowse link ISS 15 107,056,367 107,067,887 RGD:1600115 UniProtKB
G Gpr55 G protein-coupled receptor 55 GBrowse link IEA 9 84,657,975 84,658,934 RGD:1600115 ENSEMBL
G Gpr55 G protein-coupled receptor 55 GBrowse link ISO 9 84,657,975 84,658,934 RGD:1624291 RGD
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase GBrowse link IMP 2 27,127,504 27,149,580 RGD:5508698 RGD
G Hras Harvey rat sarcoma virus oncogene GBrowse link IMP 1 201,385,705 201,388,987 RGD:2314843 RGD
G Hras Harvey rat sarcoma virus oncogene GBrowse link ISO 1 201,385,705 201,388,987 RGD:1624291 RGD
G Il1a interleukin 1 alpha GBrowse link IDA 3 116,913,612 116,924,114 RGD:2311095 RGD
G Il1b interleukin 1 beta GBrowse link IDA 3 116,964,422 116,970,867 RGD:1358666 RGD
G Il6 interleukin 6 GBrowse link IDA 4 456,799 461,376 RGD:2306937 RGD
G Il6 interleukin 6 GBrowse link IDA 4 456,799 461,376 RGD:5128677 RGD
G Itgb3 integrin, beta 3 IMP RGD:4892659 RGD
G Kdr kinase insert domain receptor ISO RGD:1624291 RGD
G Kdr kinase insert domain receptor ISS RGD:1600115 UniProtKB
G LOC687735 hypothetical protein LOC687735 IEA RGD:1600115 ENSEMBL
G LOC687735 hypothetical protein LOC687735 IEA RGD:1600115 ENSEMBL
G Mapk3 mitogen activated protein kinase 3 GBrowse link ISO 1 185,935,044 185,941,245 RGD:1624291 RGD
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link ISO 20 13,191,986 13,192,851 RGD:1624291 RGD
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link ISO 20 13,191,986 13,192,851 RGD:1624291 RGD
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link ISO 20 13,191,986 13,192,851 RGD:1624291 RGD
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link ISO 20 13,191,986 13,192,851 RGD:1624291 RGD
G Mt3 metallothionein 3 GBrowse link ISO 19 11,284,554 11,286,402 RGD:1624291 RGD
G Mt3 metallothionein 3 GBrowse link ISO 19 11,284,554 11,286,402 RGD:1624291 RGD
G Mt3 metallothionein 3 GBrowse link ISS 19 11,284,554 11,286,402 RGD:1600115 UniProtKB
G Mt3 metallothionein 3 GBrowse link ISS 19 11,284,554 11,286,402 RGD:1600115 UniProtKB
G Nod1 nucleotide-binding oligomerization domain containing 1 GBrowse link ISO 4 83,398,809 83,449,207 RGD:1624291 RGD
G Nod1 nucleotide-binding oligomerization domain containing 1 GBrowse link IEA 4 83,398,809 83,449,207 RGD:1600115 ENSEMBL
G Nod2 nucleotide-binding oligomerization domain containing 2 GBrowse link ISO 19 19,662,337 19,697,341 RGD:1624291 RGD
G Nod2 nucleotide-binding oligomerization domain containing 2 GBrowse link ISO 19 19,662,337 19,697,341 RGD:1624291 RGD
G Nod2 nucleotide-binding oligomerization domain containing 2 GBrowse link IEA 19 19,662,337 19,697,341 RGD:1600115 ENSEMBL
G Nodal nodal growth differentiation factor GBrowse link IEA 20 29,546,982 29,555,419 RGD:1600115 ENSEMBL
G Nodal nodal growth differentiation factor GBrowse link ISO 20 29,546,982 29,555,419 RGD:1624291 RGD
G Nox4 NADPH oxidase 4 GBrowse link ISO 1 143,415,816 143,603,554 RGD:1624291 RGD
G Nox4 NADPH oxidase 4 GBrowse link IEA 1 143,415,816 143,603,554 RGD:1600115 ENSEMBL
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 GBrowse link NOT ISO 2 179,838,740 179,855,545 RGD:1624291 RGD
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 GBrowse link ISO 2 179,838,740 179,855,545 RGD:1624291 RGD
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 GBrowse link ISS 2 179,838,740 179,855,545 RGD:1600115 UniProtKB
G P2ry1 purinergic receptor P2Y, G-protein coupled, 1 GBrowse link IDA 2 150,460,361 150,465,855 BHF-UCL
G Pdgfa platelet-derived growth factor alpha polypeptide GBrowse link ISO 12 16,151,045 16,172,412 RGD:1624291 RGD
G Pdgfa platelet-derived growth factor alpha polypeptide GBrowse link ISS 12 16,151,045 16,172,412 RGD:1600115 UniProtKB
G Pdgfa platelet-derived growth factor alpha polypeptide GBrowse link IBA 12 16,151,045 16,172,412 RGD:1600115 RefGenome
G Pdgfb platelet-derived growth factor beta polypeptide GBrowse link ISO 7 118,244,385 118,262,021 RGD:1624291 RGD
G Pdgfb platelet-derived growth factor beta polypeptide GBrowse link ISO 7 118,244,385 118,262,021 RGD:1624291 RGD
G Pdgfb platelet-derived growth factor beta polypeptide GBrowse link ISO 7 118,244,385 118,262,021 RGD:1624291 RGD
G Pdgfb platelet-derived growth factor beta polypeptide GBrowse link IEA 7 118,244,385 118,262,021 RGD:1600115 ENSEMBL
G Pdgfb platelet-derived growth factor beta polypeptide GBrowse link ISS 7 118,244,385 118,262,021 RGD:1600115 UniProtKB
G Pdgfb platelet-derived growth factor beta polypeptide GBrowse link IBA 7 118,244,385 118,262,021 RGD:1600115 RefGenome
G Pdgfra platelet derived growth factor receptor, alpha polypeptide GBrowse link ISO 14 35,369,422 35,418,126 RGD:1624291 RGD
G Pdgfra platelet derived growth factor receptor, alpha polypeptide GBrowse link IEA 14 35,369,422 35,418,126 RGD:1600115 ENSEMBL
G Pdgfra platelet derived growth factor receptor, alpha polypeptide GBrowse link ISS 14 35,369,422 35,418,126 RGD:1600115 UniProtKB
G Pdgfrb platelet derived growth factor receptor, beta polypeptide GBrowse link ISO 18 57,014,475 57,053,581 RGD:1624291 RGD
G Pdgfrb platelet derived growth factor receptor, beta polypeptide GBrowse link ISO 18 57,014,475 57,053,581 RGD:1624291 RGD
G Pdgfrb platelet derived growth factor receptor, beta polypeptide GBrowse link ISO 18 57,014,475 57,053,581 RGD:1624291 RGD
G Pdgfrb platelet derived growth factor receptor, beta polypeptide GBrowse link ISS 18 57,014,475 57,053,581 RGD:1600115 UniProtKB
G Pdgfrb platelet derived growth factor receptor, beta polypeptide GBrowse link ISS 18 57,014,475 57,053,581 RGD:1600115 UniProtKB
G Prkca protein kinase C, alpha GBrowse link IMP 10 97,367,196 97,638,910 UniProtKB
G Prkcz protein kinase C, zeta GBrowse link ISO 5 172,061,825 172,172,793 RGD:1624291 RGD
G Prkcz protein kinase C, zeta GBrowse link IMP 5 172,061,825 172,172,793 UniProtKB
G Prkcz protein kinase C, zeta GBrowse link ISS 5 172,061,825 172,172,793 RGD:1600115 UniProtKB
G Prkd2 protein kinase D2 GBrowse link ISO 1 77,168,290 77,197,277 RGD:1624291 RGD
G Prkd2 protein kinase D2 GBrowse link ISS 1 77,168,290 77,197,277 RGD:1600115 UniProtKB
G Ptk2b protein tyrosine kinase 2 beta GBrowse link ISO 15 45,589,222 45,717,866 RGD:1624291 RGD
G Ptk2b protein tyrosine kinase 2 beta GBrowse link ISS 15 45,589,222 45,717,866 RGD:1600115 UniProtKB
G Pycard PYD and CARD domain containing GBrowse link IEA 1 187,276,089 187,277,122 RGD:1600115 ENSEMBL
G Pycard PYD and CARD domain containing GBrowse link ISO 1 187,276,089 187,277,122 RGD:1624291 RGD
G Pycard PYD and CARD domain containing GBrowse link ISO 1 187,276,089 187,277,122 RGD:1624291 RGD
G Rara retinoic acid receptor, alpha GBrowse link IMP 10 87,740,479 87,753,265 UniProtKB
G Ripk2 receptor-interacting serine-threonine kinase 2 GBrowse link ISO 5 30,714,817 30,745,941 RGD:1624291 RGD
G Ripk2 receptor-interacting serine-threonine kinase 2 GBrowse link ISO 5 30,714,817 30,745,941 RGD:1624291 RGD
G Ripk2 receptor-interacting serine-threonine kinase 2 GBrowse link IEA 5 30,714,817 30,745,941 RGD:1600115 ENSEMBL
G Scimp SLP adaptor and CSK interacting membrane protein GBrowse link ISO 10 57,687,664 57,707,493 RGD:1624291 RGD
G Scimp SLP adaptor and CSK interacting membrane protein GBrowse link ISO 10 57,687,664 57,707,493 RGD:1624291 RGD
G Scimp SLP adaptor and CSK interacting membrane protein GBrowse link IEA 10 57,687,664 57,707,493 RGD:1600115 ENSEMBL
G Scimp SLP adaptor and CSK interacting membrane protein GBrowse link IEA 10 57,687,664 57,707,493 RGD:1600115 ENSEMBL
G Sema7a semaphorin 7A, GPI membrane anchor GBrowse link ISO 8 61,717,449 61,739,529 RGD:1624291 RGD
G Sema7a semaphorin 7A, GPI membrane anchor GBrowse link ISO 8 61,717,449 61,739,529 RGD:1624291 RGD
G Sema7a semaphorin 7A, GPI membrane anchor GBrowse link IEA 8 61,717,449 61,739,529 RGD:1600115 ENSEMBL
G Serpinf2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 GBrowse link ISO 10 62,748,116 62,756,200 RGD:1624291 RGD
G Serpinf2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 GBrowse link IEA 10 62,748,116 62,756,200 RGD:1600115 ENSEMBL
G Spry2 sprouty homolog 2 (Drosophila) GBrowse link ISO 15 90,009,109 90,011,940 RGD:1624291 RGD
G Spry2 sprouty homolog 2 (Drosophila) GBrowse link IEA 15 90,009,109 90,011,940 RGD:1600115 ENSEMBL
G Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) GBrowse link ISO 3 148,157,256 148,170,524 RGD:1624291 RGD
G Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) GBrowse link IEA 3 148,157,256 148,170,524 RGD:1600115 ENSEMBL
G Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) GBrowse link IMP 3 148,157,256 148,170,524 UniProtKB
G St5 suppression of tumorigenicity 5 GBrowse link ISO 1 167,119,711 167,284,482 RGD:1624291 RGD
G St5 suppression of tumorigenicity 5 GBrowse link IEA 1 167,119,711 167,284,482 RGD:1600115 ENSEMBL
G Tek TEK tyrosine kinase, endothelial GBrowse link ISO 5 115,047,195 115,196,172 RGD:1624291 RGD
G Tek TEK tyrosine kinase, endothelial GBrowse link ISO 5 115,047,195 115,196,172 RGD:1624291 RGD
G Tek TEK tyrosine kinase, endothelial GBrowse link IEA 5 115,047,195 115,196,172 RGD:1600115 ENSEMBL
G Tff2 trefoil factor 2 GBrowse link ISO 20 9,492,341 9,510,558 RGD:1624291 RGD
G Tff2 trefoil factor 2 GBrowse link IEA 20 9,492,341 9,510,558 RGD:1600115 ENSEMBL
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein GBrowse link ISO 8 34,966,856 34,969,727 RGD:1624291 RGD
G Tlr4 toll-like receptor 4 GBrowse link ISO 5 83,564,100 83,577,735 RGD:1624291 RGD
G Tlr4 toll-like receptor 4 GBrowse link IEA 5 83,564,100 83,577,735 RGD:1600115 ENSEMBL
G Vegfb vascular endothelial growth factor B GBrowse link ISO 1 209,657,632 209,661,271 RGD:1624291 RGD
G Vegfb vascular endothelial growth factor B GBrowse link IEA 1 209,657,632 209,661,271 RGD:1600115 ENSEMBL
G Zglp1 zinc finger, GATA-like protein 1 GBrowse link ISO 8 20,086,590 20,091,165 RGD:1624291 RGD
G Zglp1 zinc finger, GATA-like protein 1 GBrowse link IEA 8 20,086,590 20,091,165 RGD:1600115 ENSEMBL
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator GBrowse link IEA 13 11,958,002 12,014,371 RGD:1600115 ENSEMBL
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator GBrowse link ISO 13 11,958,002 12,014,371 RGD:1624291 RGD
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 GBrowse link ISO 15 59,397,837 59,428,014 RGD:1624291 RGD
regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Crhr2 corticotropin releasing hormone receptor 2 GBrowse link IMP 4 83,839,822 83,867,017 RGD:5491003 RGD
G Cyr61 cysteine-rich, angiogenic inducer, 61 GBrowse link ISO 2 243,824,303 243,827,262 RGD:1624291 RGD
G Cyr61 cysteine-rich, angiogenic inducer, 61 GBrowse link IEA 2 243,824,303 243,827,262 RGD:1600115 ENSEMBL
G Epha2 Eph receptor A2 GBrowse link ISO 5 160,185,143 160,214,727 RGD:1624291 RGD
G Epha7 Eph receptor A7 GBrowse link ISO 5 44,728,037 44,878,332 RGD:1624291 RGD
G Epha7 Eph receptor A7 GBrowse link ISS 5 44,728,037 44,878,332 RGD:1600115 UniProtKB
G Ephb1 Eph receptor B1 GBrowse link ISO 8 106,871,856 107,328,156 RGD:1624291 RGD
G Ephb1 Eph receptor B1 GBrowse link ISO 8 106,871,856 107,328,156 RGD:1624291 RGD
G Ephb1 Eph receptor B1 GBrowse link ISS 8 106,871,856 107,328,156 RGD:1600115 UniProtKB
G Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GBrowse link ISO 10 87,219,157 87,242,919 RGD:1624291 RGD
G Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GBrowse link ISS 10 87,219,157 87,242,919 RGD:1600115 UniProtKB
G Fgfr2 fibroblast growth factor receptor 2 GBrowse link ISO 1 189,482,975 189,589,279 RGD:1624291 RGD
G Gstp1 glutathione S-transferase pi 1 GBrowse link ISO 1 206,627,398 206,629,866 RGD:1624291 RGD
G Gstp1 glutathione S-transferase pi 1 GBrowse link ISS 1 206,627,398 206,629,866 RGD:1600115 BHF-UCL
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISO 5 16,933,111 17,054,564 RGD:1624291 RGD
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISS 5 16,933,111 17,054,564 RGD:1600115 UniProtKB
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 GBrowse link ISO 4 160,843,699 160,868,856 RGD:1624291 RGD
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 GBrowse link IEA 4 160,843,699 160,868,856 RGD:1600115 ENSEMBL
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 GBrowse link ISS 4 160,843,699 160,868,856 RGD:1600115 UniProtKB
G Ros1 c-ros oncogene 1 , receptor tyrosine kinase GBrowse link ISO 20 30,755,101 30,910,604 RGD:1624291 RGD
G Ros1 c-ros oncogene 1 , receptor tyrosine kinase GBrowse link ISS 20 30,755,101 30,910,604 RGD:1600115 UniProtKB
G Syk spleen tyrosine kinase GBrowse link ISO 17 18,440,672 18,498,001 RGD:1624291 RGD
G Syk spleen tyrosine kinase GBrowse link IEA 17 18,440,672 18,498,001 RGD:1600115 ENSEMBL
G Syk spleen tyrosine kinase GBrowse link ISS 17 18,440,672 18,498,001 RGD:1600115 UniProtKB
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135981
    cellular process 85166
      regulation of cellular process 43261
        signal transduction 13563
          intracellular signal transduction 4916
            intracellular protein kinase cascade 2610
              MAPK cascade 1412
                ERK1 and ERK2 cascade 303
                  negative regulation of ERK1 and ERK2 cascade 49
                  positive regulation of ERK1 and ERK2 cascade + 191
                  regulation of ERK1 and ERK2 cascade + 264
Path 2
Term Annotations click to browse term
  biological_process 135981
    single-organism process 88424
      single-organism cellular process 56364
        cellular response to stimulus 19012
          signal transduction 13563
            intracellular signal transduction 4916
              intracellular protein kinase cascade 2610
                MAPK cascade 1412
                  ERK1 and ERK2 cascade 303
                    negative regulation of ERK1 and ERK2 cascade 49
                    positive regulation of ERK1 and ERK2 cascade + 191
                    regulation of ERK1 and ERK2 cascade + 264
paths to the root

Contact Us |  About Us |  Jobs at RGD