stress-activated MAPK cascade - Ontology Report

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Term:	stress-activated MAPK cascade	go back to main search page
Accession:	GO:0051403	browse the term
Definition:	A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
Synonyms:	exact_synonym:	stress-activated MAPK signaling pathway; stress-activated MAPK signalling pathway; stress-activated MAPKKK cascade; stress-activated MAPKKK signaling pathway; stress-activated MAPKKK signalling pathway
	narrow_synonym:	MAPK11 cascade; MAPK12 cascade; MAPK13 cascade; MAPK14 cascade; p38 MAPK signaling; p38 MAPK signalling; p38 cascade
	broad_synonym:	SAPK cascade
	xref_analog:	Reactome:REACT_103389; Reactome:REACT_104595; Reactome:REACT_104796; Reactome:REACT_105109; Reactome:REACT_109896; Reactome:REACT_21308; Reactome:REACT_30115; Reactome:REACT_32136; Reactome:REACT_34622; Reactome:REACT_79433; Reactome:REACT_82500; Reactome:REACT_85645; Reactome:REACT_85847; Reactome:REACT_89123; Reactome:REACT_95758; Reactome:REACT_95991; Reactome:REACT_98311

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stress-activated MAPK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)			IEA	1	230,838,269	230,850,336	RGD:2290271	ENSEMBL
G	ATF1	activating transcription factor 1			TAS	12	51,157,789	51,214,943	RGD:2290271	Reactome
G	ATF2	activating transcription factor 2			TAS	2	175,936,978	176,032,934	RGD:2290271	Reactome
G	CCM2	cerebral cavernous malformation 2			TAS	7	45,039,345	45,116,069	RGD:2290271	UniProtKB
G	CDK1	cyclin-dependent kinase 1			TAS	10	62,538,089	62,554,610	RGD:2290271	Reactome
G	CREB1	cAMP responsive element binding protein 1			TAS	2	208,394,616	208,470,284	RGD:2290271	Reactome
G	CRYAB	crystallin, alpha B			IEA	11	111,779,350	111,782,473	RGD:2290271	ENSEMBL
G	DUSP3	dual specificity phosphatase 3			TAS	17	41,843,489	41,856,368	RGD:2290271	Reactome
G	DUSP4	dual specificity phosphatase 4			TAS	8	29,190,579	29,208,267	RGD:2290271	Reactome
G	DUSP6	dual specificity phosphatase 6			TAS	12	89,741,837	89,746,296	RGD:2290271	Reactome
G	DUSP7	dual specificity phosphatase 7			TAS	3	52,082,935	52,090,461	RGD:2290271	Reactome
G	ELK1	ELK1, member of ETS oncogene family			TAS	X	47,494,919	47,510,003	RGD:2290271	Reactome
G	FOS	FBJ murine osteosarcoma viral oncogene homolog			TAS	14	75,745,481	75,748,937	RGD:2290271	Reactome
G	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma			TAS	X	153,770,459	153,793,261	RGD:2290271	Reactome
G	IRAK1	interleukin-1 receptor-associated kinase 1			TAS	X	153,275,957	153,285,342	RGD:2290271	Reactome
G	IRAK2	interleukin-1 receptor-associated kinase 2			TAS	3	10,206,563	10,285,427	RGD:2290271	Reactome
G	JUN	jun proto-oncogene			TAS	1	59,246,463	59,249,785	RGD:2290271	Reactome
G	MAP2K1	mitogen-activated protein kinase kinase 1			TAS	15	66,679,211	66,783,882	RGD:2290271	Reactome
G	MAP2K2	mitogen-activated protein kinase kinase 2			TAS	19	4,090,319	4,124,126	RGD:2290271	Reactome
G	MAP2K3	mitogen-activated protein kinase kinase 3			TAS	17	21,187,968	21,218,552	RGD:2290271	Reactome
G	MAP2K4	mitogen-activated protein kinase kinase 4			TAS	17	11,924,135	12,047,051	RGD:2290271	Reactome
G	MAP2K6	mitogen-activated protein kinase kinase 6			TAS	17	67,410,838	67,538,470	RGD:2290271	Reactome
G	MAP2K7	mitogen-activated protein kinase kinase 7			IDA	19	7,968,765	7,979,363	RGD:2290271	UniProtKB
G	MAP2K7	mitogen-activated protein kinase kinase 7			TAS	19	7,968,765	7,979,363	RGD:2290271	Reactome
G	MAP3K7	mitogen-activated protein kinase kinase kinase 7			IDA	6	91,223,292	91,297,020	RGD:2290271	UniProtKB
G	MAP3K7	mitogen-activated protein kinase kinase kinase 7			TAS	6	91,223,292	91,297,020	RGD:2290271	Reactome
G	MAPK1	mitogen-activated protein kinase 1			TAS	22	22,113,946	22,221,970	RGD:2290271	Reactome
G	MAPK10	mitogen-activated protein kinase 10			TAS	4	86,936,276	87,374,283	RGD:2290271	Reactome
G	MAPK11	mitogen-activated protein kinase 11			TAS	22	50,702,142	50,708,779	RGD:2290271	Reactome
G	MAPK14	mitogen-activated protein kinase 14			TAS	6	35,995,454	36,079,013	RGD:2290271	Reactome
G	MAPK3	mitogen-activated protein kinase 3			TAS	16	30,125,426	30,134,630	RGD:2290271	Reactome
G	MAPK7	mitogen-activated protein kinase 7			TAS	17	19,281,034	19,286,857	RGD:2290271	Reactome
G	MAPK8	mitogen-activated protein kinase 8			TAS	10	49,609,687	49,643,183	RGD:2290271	Reactome
G	MAPK9	mitogen-activated protein kinase 9			TAS	5	179,660,594	179,719,071	RGD:2290271	Reactome
G	MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2			TAS	1	206,858,365	206,907,630	RGD:2290271	Reactome
G	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3			TAS	3	50,649,293	50,686,728	RGD:2290271	Reactome
G	MEF2A	myocyte enhancer factor 2A			TAS	15	100,106,133	100,256,630	RGD:2290271	Reactome
G	MEF2C	myocyte enhancer factor 2C			TAS	5	88,014,058	88,199,922	RGD:2290271	Reactome
G	NOD1	nucleotide-binding oligomerization domain containing 1			TAS	7	30,464,143	30,518,393	RGD:2290271	Reactome
G	NOD2	nucleotide-binding oligomerization domain containing 2			TAS	16	50,731,050	50,766,987	RGD:2290271	Reactome
G	PPP2R5D	protein phosphatase 2, regulatory subunit B', delta			TAS	6	42,952,237	42,980,083	RGD:2290271	Reactome
G	RBM4	RNA binding motif protein 4			IDA	11	66,406,088	66,435,856	RGD:2290271	UniProtKB
G	RIPK2	receptor-interacting serine-threonine kinase 2			TAS	8	90,769,975	90,803,292	RGD:2290271	Reactome
G	RPS27A	ribosomal protein S27a			TAS	2	55,459,039	55,462,989	RGD:2290271	Reactome
G	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1			TAS	1	26,856,249	26,901,520	RGD:2290271	Reactome
G	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2			TAS	6	166,822,854	167,275,771	RGD:2290271	Reactome
G	RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3			TAS	X	20,168,029	20,284,750	RGD:2290271	Reactome
G	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5			TAS	14	91,337,159	91,526,993	RGD:2290271	Reactome
G	TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1			TAS	22	39,795,759	39,833,132	RGD:2290271	Reactome
G	TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2			TAS	6	149,639,436	149,732,747	RGD:2290271	Reactome
G	TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3			TAS	X	30,845,559	30,907,511	RGD:2290271	Reactome
G	TAOK2	TAO kinase 2			IDA	16	29,985,188	30,003,582	RGD:2290271	UniProtKB
G	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase			TAS	11	36,505,317	36,531,863	RGD:2290271	Reactome
G	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1			TAS	19	18,682,614	18,688,270	RGD:2290271	Reactome
G	UBB	ubiquitin B			TAS	17	16,284,367	16,286,054	RGD:2290271	Reactome
G	UBC	ubiquitin C			TAS	12	125,396,192	125,399,587	RGD:2290271	Reactome
activation of JNKK activity
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6			IEA	10	50,664,491	50,747,147	RGD:2290271	ENSEMBL
G	MAP3K10	mitogen-activated protein kinase kinase kinase 10			ISS	19	40,697,651	40,721,482	RGD:2290271	GOC
G	MAP3K9	mitogen-activated protein kinase kinase kinase 9			ISS	14	71,194,852	71,275,888	RGD:2290271	GOC
G	MAPKBP1	mitogen-activated protein kinase binding protein 1			IEA	15	42,066,632	42,120,053	RGD:2290271	ENSEMBL
G	NRK	Nik related kinase			IEA	X	105,066,536	105,202,602	RGD:2290271	ENSEMBL
G	TNIK	TRAF2 and NCK interacting kinase			IMP	3	170,780,292	171,178,197	RGD:2290271	UniProtKB
G	TNIK	TRAF2 and NCK interacting kinase			IDA	3	170,780,292	171,178,197	RGD:2290271	UniProtKB
activation of JUN kinase activity
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	AXIN1	axin 1			IBA	16	337,440	402,676	RGD:2290271	RefGenome
G	BIRC7	baculoviral IAP repeat containing 7			NAS	20	61,867,276	61,871,854	RGD:2290271	UniProtKB
G	CCL19	chemokine (C-C motif) ligand 19			ISS	9	34,689,567	34,691,274	RGD:2290271	BHF-UCL
G	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)			IEA	5	39,371,776	39,425,335	RGD:2290271	ENSEMBL
G	DAB2IP	DAB2 interacting protein			IDA	9	124,329,399	124,547,809	RGD:2290271	BHF-UCL
G	DAXX	death-domain associated protein			TAS	6	33,286,335	33,290,793	RGD:2290271	PINC
G	DBNL	drebrin-like			TAS	7	44,084,239	44,101,315	RGD:2290271	PINC
G	ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6			IEA	10	50,664,491	50,747,147	RGD:2290271	ENSEMBL
G	FCER1A	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide			IEA	1	159,253,678	159,278,014	RGD:2290271	ENSEMBL
G	GAB1	GRB2-associated binding protein 1			IEA	4	144,257,983	144,395,718	RGD:2290271	ENSEMBL
G	KIAA1804	mixed lineage kinase 4			ISS	1	233,463,514	233,520,894	RGD:2290271	UniProtKB
G	MAP2K7	mitogen-activated protein kinase kinase 7			ISS	19	7,968,765	7,979,363	RGD:2290271	BHF-UCL
G	MAP3K10	mitogen-activated protein kinase kinase kinase 10			ISS	19	40,697,651	40,721,482	RGD:2290271	UniProtKB
G	MAP3K11	mitogen-activated protein kinase kinase kinase 11			IMP	11	65,365,226	65,381,720	RGD:2290271	UniProtKB
G	MAP3K2	mitogen-activated protein kinase kinase kinase 2			TAS	2	128,056,245	128,100,805	RGD:2290271	PINC
G	MAP3K5	mitogen-activated protein kinase kinase kinase 5			TAS	6	136,878,187	137,113,656	RGD:2290271	PINC
G	MAP3K6	mitogen-activated protein kinase kinase kinase 6			TAS	1	27,681,670	27,693,337	RGD:2290271	PINC
G	MAP3K9	mitogen-activated protein kinase kinase kinase 9			ISS	14	71,194,852	71,275,888	RGD:2290271	UniProtKB
G	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1			TAS	19	39,078,281	39,108,643	RGD:2290271	PINC
G	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2			IDA	11	64,556,609	64,570,713	RGD:2290271	UniProtKB
G	MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5			TAS	14	50,885,211	50,999,376	RGD:2290271	PINC
G	MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3			IEA	16	1,756,221	1,820,318	RGD:2290271	ENSEMBL
G	MDFI	MyoD family inhibitor			IEA	6	41,606,195	41,621,982	RGD:2290271	ENSEMBL
G	MDFIC	MyoD family inhibitor domain containing			IDA	7	114,562,209	114,659,970	RGD:2290271	UniProtKB
G	MUL1	mitochondrial E3 ubiquitin protein ligase 1			IDA	1	20,825,941	20,834,674	RGD:2290271	UniProtKB
G	PKN1	protein kinase N1			TAS	19	14,544,166	14,582,679	RGD:2290271	PINC
G	PTPLAD1	protein tyrosine phosphatase-like A domain containing 1			TAS	15	65,822,827	65,870,693	RGD:2290271	PINC
G	RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1			TAS	6	3,077,058	3,115,421	RGD:2290271	BHF-UCL
G	SPAG9	sperm associated antigen 9			IEA	17	49,039,535	49,198,226	RGD:2290271	ENSEMBL
G	SYK	spleen tyrosine kinase			IEA	9	93,564,012	93,660,842	RGD:2290271	ENSEMBL
G	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11			IEA	13	43,136,872	43,182,149	RGD:2290271	ENSEMBL
G	WNT5A	wingless-type MMTV integration site family, member 5A			IDA	3	55,499,743	55,521,670	RGD:2290271	BHF-UCL
G	WNT5A	wingless-type MMTV integration site family, member 5A			IMP	3	55,499,743	55,521,670	RGD:2290271	BHF-UCL
G	ZAK	sterile alpha motif and leucine zipper containing kinase AZK			IDA	2	173,940,565	174,132,737	RGD:2290271	UniProtKB
JNK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	ADORA2B	adenosine A2b receptor			TAS	17	15,848,231	15,879,210	RGD:2290271	PINC
G	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6			NAS	X	135,747,709	135,863,503	RGD:2290271	UniProtKB
G	CASR	calcium-sensing receptor			IEA	3	121,902,530	122,005,344	RGD:2290271	ENSEMBL
G	CDC42EP5	CDC42 effector protein (Rho GTPase binding) 5			IEA	19	54,976,210	54,984,422	RGD:2290271	ENSEMBL
G	CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like			TAS	22	21,271,714	21,308,037	RGD:2290271	PINC
G	DUSP10	dual specificity phosphatase 10			TAS	1	221,874,764	221,915,516	RGD:2290271	PINC
G	DUSP12	dual specificity phosphatase 12		NOT	IRD	1	161,719,581	161,726,952	RGD:2290271	RefGenome
G	DUSP19	dual specificity phosphatase 19			IBA	2	183,943,287	183,964,736	RGD:2290271	RefGenome
G	DUSP9	dual specificity phosphatase 9			TAS	X	152,907,897	152,916,781	RGD:2290271	PINC
G	FGF12	fibroblast growth factor 12			IPI	3	191,857,182	192,445,388	RGD:2290271	MGI
G	FGF14	fibroblast growth factor 14			IPI	13	102,373,205	103,054,124	RGD:2290271	MGI
G	GPS1	G protein pathway suppressor 1			TAS	17	80,009,763	80,015,346	RGD:2290271	PINC
G	GPS2	G protein pathway suppressor 2			TAS	17	7,215,978	7,218,658	RGD:2290271	PINC
G	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma			TAS	X	153,770,459	153,793,261	RGD:2290271	Reactome
G	IRAK1	interleukin-1 receptor-associated kinase 1			TAS	X	153,275,957	153,285,342	RGD:2290271	Reactome
G	IRAK2	interleukin-1 receptor-associated kinase 2			TAS	3	10,206,563	10,285,427	RGD:2290271	Reactome
G	IRAK4	interleukin-1 receptor-associated kinase 4			IEA	12	44,152,747	44,183,346	RGD:2290271	ENSEMBL
G	MAP2K4	mitogen-activated protein kinase kinase 4			TAS	17	11,924,135	12,047,051	RGD:2290271	Reactome
G	MAP2K7	mitogen-activated protein kinase kinase 7			TAS	19	7,968,765	7,979,363	RGD:2290271	Reactome
G	MAP3K10	mitogen-activated protein kinase kinase kinase 10			TAS	19	40,697,651	40,721,482	RGD:2290271	PINC
G	MAP3K11	mitogen-activated protein kinase kinase kinase 11			TAS	11	65,365,226	65,381,720	RGD:2290271	PINC
G	MAP3K12	mitogen-activated protein kinase kinase kinase 12			ISS	12	53,874,276	53,893,444	RGD:2290271	UniProtKB
G	MAP3K13	mitogen-activated protein kinase kinase kinase 13			IDA	3	185,000,729	185,206,882	RGD:2290271	UniProtKB
G	MAP3K13	mitogen-activated protein kinase kinase kinase 13			IDA	3	185,000,729	185,206,882	RGD:2290271	UniProtKB
G	MAP3K4	mitogen-activated protein kinase kinase kinase 4			TAS	6	161,412,822	161,538,417	RGD:2290271	PINC
G	MAP3K5	mitogen-activated protein kinase kinase kinase 5			IDA	6	136,878,187	137,113,656	RGD:2290271	UniProtKB
G	MAP3K7	mitogen-activated protein kinase kinase kinase 7			IDA	6	91,223,292	91,297,020	RGD:2290271	UniProtKB
G	MAP3K7	mitogen-activated protein kinase kinase kinase 7			TAS	6	91,223,292	91,297,020	RGD:2290271	Reactome
G	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2			TAS	11	64,556,609	64,570,713	RGD:2290271	PINC
G	MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3			TAS	2	39,476,407	39,664,453	RGD:2290271	PINC
G	MAPK10	mitogen-activated protein kinase 10			ISS	4	86,936,276	87,374,283	RGD:2290271	UniProtKB
G	MAPK10	mitogen-activated protein kinase 10			TAS	4	86,936,276	87,374,283	RGD:2290271	Reactome
G	MAPK8	mitogen-activated protein kinase 8			IDA	10	49,609,687	49,643,183	RGD:2290271	UniProtKB
G	MAPK8	mitogen-activated protein kinase 8			TAS	10	49,609,687	49,643,183	RGD:2290271	Reactome
G	MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2			IEA	22	51,039,131	51,049,979	RGD:2290271	ENSEMBL
G	MAPK9	mitogen-activated protein kinase 9			IDA	5	179,660,594	179,719,071	RGD:2290271	UniProtKB
G	MAPK9	mitogen-activated protein kinase 9			TAS	5	179,660,594	179,719,071	RGD:2290271	Reactome
G	MINK1	misshapen-like kinase 1			TAS	17	4,736,635	4,801,356	RGD:2290271	PINC
G	MYD88	myeloid differentiation primary response 88			IEA	3	38,179,969	38,184,513	RGD:2290271	ENSEMBL
G	NOD1	nucleotide-binding oligomerization domain containing 1			TAS	7	30,464,143	30,518,393	RGD:2290271	Reactome
G	NOD2	nucleotide-binding oligomerization domain containing 2			TAS	16	50,731,050	50,766,987	RGD:2290271	Reactome
G	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)			IEA	19	36,316,274	36,342,895	RGD:2290271	ENSEMBL
G	PTGER4	prostaglandin E receptor 4 (subtype EP4)			ISS	5	40,680,032	40,693,837	RGD:2290271	UniProtKB
G	PTK2	protein tyrosine kinase 2			IEA	8	141,668,481	142,011,412	RGD:2290271	ENSEMBL
G	PTPLAD1	protein tyrosine phosphatase-like A domain containing 1			IEA	15	65,822,827	65,870,693	RGD:2290271	ENSEMBL
G	RB1CC1	RB1-inducible coiled-coil 1			IEA	8	53,535,018	53,627,026	RGD:2290271	ENSEMBL
G	RIPK2	receptor-interacting serine-threonine kinase 2			TAS	8	90,769,975	90,803,292	RGD:2290271	Reactome
G	ROR2	receptor tyrosine kinase-like orphan receptor 2			IEA	9	94,484,878	94,712,444	RGD:2290271	ENSEMBL
G	RPS27A	ribosomal protein S27a			TAS	2	55,459,039	55,462,989	RGD:2290271	Reactome
G	SH2D3A	SH2 domain containing 3A			TAS	19	6,752,171	6,767,523	RGD:2290271	PINC
G	SH2D3C	SH2 domain containing 3C			TAS	9	130,500,596	130,541,048	RGD:2290271	PINC
G	STRADB	STE20-related kinase adaptor beta			IEA	2	202,316,392	202,345,574	RGD:2290271	ENSEMBL
G	TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1			TAS	22	39,795,759	39,833,132	RGD:2290271	Reactome
G	TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2			TAS	6	149,639,436	149,732,747	RGD:2290271	Reactome
G	TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3			TAS	X	30,845,559	30,907,511	RGD:2290271	Reactome
G	TNF	tumor necrosis factor			IEA	6	31,543,344	31,546,113	RGD:2290271	ENSEMBL
G	TNFRSF19	tumor necrosis factor receptor superfamily, member 19			NAS	13	24,144,509	24,250,244	RGD:2290271	UniProtKB
G	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase			TAS	11	36,505,317	36,531,863	RGD:2290271	Reactome
G	TRIB1	tribbles homolog 1 (Drosophila)			IMP	8	126,442,563	126,450,645	RGD:2290271	BHF-UCL
G	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1			TAS	19	18,682,614	18,688,270	RGD:2290271	Reactome
G	UBB	ubiquitin B			TAS	17	16,284,367	16,286,054	RGD:2290271	Reactome
G	UBC	ubiquitin C			TAS	12	125,396,192	125,399,587	RGD:2290271	Reactome
JUN phosphorylation
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	MAPK10	mitogen-activated protein kinase 10			TAS	4	86,936,276	87,374,283	RGD:2290271	GOC
G	MAPK10	mitogen-activated protein kinase 10			ISS	4	86,936,276	87,374,283	RGD:2290271	GOC
G	MAPK8	mitogen-activated protein kinase 8			IDA	10	49,609,687	49,643,183	RGD:2290271	MGI
G	MAPK8	mitogen-activated protein kinase 8			IDA	10	49,609,687	49,643,183	RGD:2290271	UniProtKB
G	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1			IEA	11	45,907,047	45,928,016	RGD:2290271	ENSEMBL
negative regulation of JNK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	AIDA	axin interactor, dorsalization associated			ISS	1	222,841,355	222,885,864	RGD:2290271	UniProtKB
G	AKT1	v-akt murine thymoma viral oncogene homolog 1			IEA	14	105,235,686	105,262,080	RGD:2290271	ENSEMBL
G	AMBP	alpha-1-microglobulin/bikunin precursor			TAS	9	116,822,407	116,840,752	RGD:2290271	UniProtKB
G	DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)			IDA	14	59,100,786	59,115,039	RGD:2290271	UniProtKB
G	DUSP10	dual specificity phosphatase 10			IBA	1	221,874,764	221,915,516	RGD:2290271	RefGenome
G	DUSP19	dual specificity phosphatase 19			ISS	2	183,943,287	183,964,736	RGD:2290271	BHF-UCL
G	DUSP3	dual specificity phosphatase 3			IDA	17	41,843,489	41,856,368	RGD:2290271	UniProtKB
G	DUSP3	dual specificity phosphatase 3			IMP	17	41,843,489	41,856,368	RGD:2290271	UniProtKB
G	F2RL1	coagulation factor II (thrombin) receptor-like 1			IDA	5	76,114,833	76,131,140	RGD:2290271	UniProtKB
G	FKTN	fukutin			IMP	9	108,320,411	108,403,399	RGD:2290271	BHF-UCL
G	GPS2	G protein pathway suppressor 2			IDA	17	7,215,978	7,218,658	RGD:2290271	UniProtKB
G	HDAC3	histone deacetylase 3			IMP	5	141,000,443	141,016,423	RGD:2290271	UniProtKB
G	ITCH	itchy E3 ubiquitin protein ligase			ISS	20	32,951,041	33,099,198	RGD:2290271	BHF-UCL
G	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1			IEA	11	45,907,047	45,928,016	RGD:2290271	ENSEMBL
G	MECOM	MDS1 and EVI1 complex locus			IMP	3	168,801,287	169,381,563	RGD:2290271	UniProtKB
G	MEN1	multiple endocrine neoplasia I			IDA	11	64,570,986	64,578,766	RGD:2290271	UniProtKB
G	NCOR1	nuclear receptor corepressor 1			IDA	17	15,933,408	16,118,874	RGD:2290271	UniProtKB
G	PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)			IEA	17	2,496,923	2,588,909	RGD:2290271	ENSEMBL
G	SFRP4	secreted frizzled-related protein 4			IBA	7	37,945,534	37,956,525	RGD:2290271	RefGenome
G	TAOK3	TAO kinase 3			IDA	12	118,587,606	118,810,750	RGD:2290271	HGNC
G	ZMYND11	zinc finger, MYND-type containing 11			IMP	10	180,405	300,577	RGD:2290271	UniProtKB
G	ZNF675	zinc finger protein 675			IDA	19	23,835,708	23,870,017	RGD:2290271	UniProtKB
negative regulation of JUN kinase activity
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	AIDA	axin interactor, dorsalization associated			IDA	1	222,841,355	222,885,864	RGD:2290271	MGI
G	DUSP10	dual specificity phosphatase 10			IBA	1	221,874,764	221,915,516	RGD:2290271	RefGenome
G	DUSP19	dual specificity phosphatase 19			ISS	2	183,943,287	183,964,736	RGD:2290271	BHF-UCL
G	GSTP1	glutathione S-transferase pi 1			IDA	11	67,351,066	67,354,124	RGD:2290271	BHF-UCL
G	HIPK3	homeodomain interacting protein kinase 3			IEA	11	33,279,168	33,375,939	RGD:2290271	ENSEMBL
G	HIPK3	homeodomain interacting protein kinase 3			ISS	11	33,279,168	33,375,939	RGD:2290271	UniProtKB
G	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1			IEA	11	45,907,047	45,928,016	RGD:2290271	ENSEMBL
G	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)			ISS	10	112,631,553	112,659,764	RGD:2290271	UniProtKB
G	SFRP1	secreted frizzled-related protein 1			IEA	8	41,119,476	41,166,990	RGD:2290271	ENSEMBL
G	SFRP2	secreted frizzled-related protein 2			IEA	4	154,701,742	154,710,228	RGD:2290271	ENSEMBL
G	SFRP5	secreted frizzled-related protein 5			IEA	10	99,526,508	99,531,756	RGD:2290271	ENSEMBL
G	TP73	tumor protein p73			IBA	1	3,569,129	3,652,765	RGD:2290271	RefGenome
G	ZNF675	zinc finger protein 675			IDA	19	23,835,708	23,870,017	RGD:2290271	BHF-UCL
negative regulation of stress-activated MAPK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	DUSP10	dual specificity phosphatase 10			IBA	1	221,874,764	221,915,516	RGD:2290271	RefGenome
G	FOXM1	forkhead box M1			IMP	12	2,966,847	2,986,321	RGD:2290271	BHF-UCL
G	FOXO1	forkhead box O1			IDA	13	41,129,801	41,240,734	RGD:2290271	BHF-UCL
G	GSTP1	glutathione S-transferase pi 1			ISS	11	67,351,066	67,354,124	RGD:2290271	BHF-UCL
G	IGBP1	immunoglobulin (CD79A) binding protein 1			IMP	X	69,353,318	69,386,174	RGD:2290271	UniProtKB
G	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)			ISS	8	128,748,315	128,753,680	RGD:2290271	UniProtKB
positive regulation of JNK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	AXIN1	axin 1			ISS	16	337,440	402,676	RGD:2290271	UniProtKB
G	CARD9	caspase recruitment domain family, member 9			IDA	9	139,258,408	139,268,133	RGD:2290271	MGI
G	CCL19	chemokine (C-C motif) ligand 19			IDA	9	34,689,567	34,691,274	RGD:2290271	BHF-UCL
G	CCL21	chemokine (C-C motif) ligand 21			IDA	9	34,709,002	34,710,147	RGD:2290271	BHF-UCL
G	CCR7	chemokine (C-C motif) receptor 7			IC	17	38,710,021	38,721,736	RGD:2290271	BHF-UCL
G	CD27	CD27 molecule			ISS	12	6,554,051	6,560,884	RGD:2290271	UniProtKB
G	CDC42	cell division cycle 42			IEA	1	22,379,120	22,419,436	RGD:2290271	ENSEMBL
G	CTGF	connective tissue growth factor			IDA	6	132,269,316	132,272,518	RGD:2290271	BHF-UCL
G	DAB2IP	DAB2 interacting protein			IDA	9	124,329,399	124,547,809	RGD:2290271	UniProtKB
G	DAB2IP	DAB2 interacting protein			IDA	9	124,329,399	124,547,809	RGD:2290271	UniProtKB
G	DIXDC1	DIX domain containing 1			IEA	11	111,807,927	111,893,308	RGD:2290271	ENSEMBL
G	DUSP19	dual specificity phosphatase 19			ISS	2	183,943,287	183,964,736	RGD:2290271	BHF-UCL
G	DUSP22	dual specificity phosphatase 22			IBA	6	292,101	351,355	RGD:2290271	RefGenome
G	EDA2R	ectodysplasin A2 receptor			IDA	X	65,815,479	65,859,140	RGD:2290271	HGNC
G	F2RL1	coagulation factor II (thrombin) receptor-like 1			IDA	5	76,114,833	76,131,140	RGD:2290271	UniProtKB
G	FGF19	fibroblast growth factor 19			IDA	11	69,513,006	69,519,106	RGD:2290271	UniProtKB
G	FLT4	fms-related tyrosine kinase 4			IMP	5	180,028,506	180,076,624	RGD:2290271	UniProtKB
G	FZD7	frizzled family receptor 7			IC	2	202,899,310	202,903,160	RGD:2290271	BHF-UCL
G	HIPK2	homeodomain interacting protein kinase 2			IMP	7 7	139,246,316 139,415,730	139,342,363 139,477,693	RGD:2290271	UniProtKB
G	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog			IDA	11	532,242	535,550	RGD:2290271	BHF-UCL
G	IL1B	interleukin 1, beta			IEA	2	113,587,337	113,594,356	RGD:2290271	ENSEMBL
G	LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)			IMP	12	6,484,534	6,500,737	RGD:2290271	UniProtKB
G	MAP3K10	mitogen-activated protein kinase kinase kinase 10			IMP	19	40,697,651	40,721,482	RGD:2290271	UniProtKB
G	MAP3K11	mitogen-activated protein kinase kinase kinase 11			IMP	11	65,365,226	65,381,720	RGD:2290271	UniProtKB
G	MAP3K7	mitogen-activated protein kinase kinase kinase 7			IEA	6	91,223,292	91,297,020	RGD:2290271	ENSEMBL
G	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2			IDA	11	64,556,609	64,570,713	RGD:2290271	UniProtKB
G	MINK1	misshapen-like kinase 1			IMP	17	4,736,635	4,801,356	RGD:2290271	UniProtKB
G	MYD88	myeloid differentiation primary response 88			IEA	3	38,179,969	38,184,513	RGD:2290271	ENSEMBL
G	NOD1	nucleotide-binding oligomerization domain containing 1			IEA	7	30,464,143	30,518,393	RGD:2290271	ENSEMBL
G	NOD2	nucleotide-binding oligomerization domain containing 2			IDA	16	50,731,050	50,766,987	RGD:2290271	MGI
G	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)			IDA	20	8,113,296	8,865,547	RGD:2290271	BHF-UCL
G	PTK2B	protein tyrosine kinase 2 beta			IMP	8	27,168,999	27,316,908	RGD:2290271	UniProtKB
G	PYCARD	PYD and CARD domain containing			IMP	16	31,212,807	31,214,097	RGD:2290271	UniProtKB
G	RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1			IDA	6	3,077,058	3,115,421	RGD:2290271	UniProtKB
G	RIPK2	receptor-interacting serine-threonine kinase 2			IEA	8	90,769,975	90,803,292	RGD:2290271	ENSEMBL
G	SDCBP	syndecan binding protein (syntenin)			IC	8	59,465,728	59,495,419	RGD:2290271	BHF-UCL
G	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2			IDA	17	1,646,130	1,658,559	RGD:2290271	BHF-UCL
G	STK3	serine/threonine kinase 3			IEA	8	99,466,859	99,954,799	RGD:2290271	ENSEMBL
G	TAOK1	TAO kinase 1			IDA	17	27,717,943	27,878,921	RGD:2290271	UniProtKB
G	TAOK2	TAO kinase 2			IDA	16	29,985,188	30,003,582	RGD:2290271	UniProtKB
G	TAOK3	TAO kinase 3			IMP	12	118,587,606	118,810,750	RGD:2290271	HGNC
G	TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein			IMP	11	126,152,982	126,164,828	RGD:2290271	BHF-UCL
G	TLR3	toll-like receptor 3			IEA	4	186,990,309	187,006,252	RGD:2290271	ENSEMBL
G	TLR4	toll-like receptor 4			IEA	9	120,466,453	120,479,769	RGD:2290271	ENSEMBL
G	TLR9	toll-like receptor 9			IC	3	52,255,096	52,260,179	RGD:2290271	BHF-UCL
G	TNF	tumor necrosis factor			IEA	6	31,543,344	31,546,113	RGD:2290271	ENSEMBL
G	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11			IEA	13	43,136,872	43,182,149	RGD:2290271	ENSEMBL
G	TPD52L1	tumor protein D52-like 1			IDA	6	125,474,879	125,584,644	RGD:2290271	UniProtKB
G	TRAF4	TNF receptor-associated factor 4			IDA	17	27,071,023	27,077,976	RGD:2290271	UniProtKB
G	TRAF4	TNF receptor-associated factor 4			IEA	17	27,071,023	27,077,976	RGD:2290271	InterPro
G	WNT16	wingless-type MMTV integration site family, member 16			IMP	7	120,965,421	120,981,158	RGD:2290271	BHF-UCL
G	WNT5A	wingless-type MMTV integration site family, member 5A			IEA	3	55,499,743	55,521,670	RGD:2290271	ENSEMBL
G	WNT7A	wingless-type MMTV integration site family, member 7A			IBA	3	13,860,082	13,921,618	RGD:2290271	RefGenome
G	WNT7B	wingless-type MMTV integration site family, member 7B			IBA	22	46,316,246	46,373,008	RGD:2290271	RefGenome
G	ZNF622	zinc finger protein 622			IMP	5	16,451,628	16,465,894	RGD:2290271	UniProtKB
positive regulation of JUN kinase activity
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	DAB2IP	DAB2 interacting protein			IDA	9	124,329,399	124,547,809	RGD:2290271	BHF-UCL
G	DAB2IP	DAB2 interacting protein			IEA	9	124,329,399	124,547,809	RGD:2290271	ENSEMBL
G	DUSP19	dual specificity phosphatase 19			ISS	2	183,943,287	183,964,736	RGD:2290271	BHF-UCL
G	DVL2	dishevelled, dsh homolog 2 (Drosophila)			IDA	17	7,128,661	7,137,863	RGD:2290271	BHF-UCL
G	DVL2	dishevelled, dsh homolog 2 (Drosophila)			IMP	17	7,128,661	7,137,863	RGD:2290271	BHF-UCL
G	DVL3	dishevelled, dsh homolog 3 (Drosophila)			IMP	3	183,873,284	183,891,314	RGD:2290271	BHF-UCL
G	EDN1	endothelin 1			IDA	6	12,290,529	12,297,427	RGD:2290271	BHF-UCL
G	EPHA4	EPH receptor A4			IEA	2	222,282,747	222,437,010	RGD:2290271	ENSEMBL
G	FZD10	frizzled family receptor 10			IMP	12	130,647,004	130,650,285	RGD:2290271	BHF-UCL
G	FZD4	frizzled family receptor 4			IEA	11	86,656,717	86,666,440	RGD:2290271	ENSEMBL
G	FZD5	frizzled family receptor 5			IEA	2	208,627,310	208,634,143	RGD:2290271	ENSEMBL
G	FZD8	frizzled family receptor 8			IEA	10	35,927,177	35,930,362	RGD:2290271	ENSEMBL
G	IL1RN	interleukin 1 receptor antagonist			IEA	2	113,875,470	113,891,593	RGD:2290271	ENSEMBL
G	MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3			IEA	1	113,933,475	114,228,545	RGD:2290271	ENSEMBL
G	MAP3K10	mitogen-activated protein kinase kinase kinase 10			IMP	19	40,697,651	40,721,482	RGD:2290271	UniProtKB
G	MAP3K11	mitogen-activated protein kinase kinase kinase 11			IMP	11	65,365,226	65,381,720	RGD:2290271	UniProtKB
G	MAP3K4	mitogen-activated protein kinase kinase kinase 4			ISS	6	161,412,822	161,538,417	RGD:2290271	UniProtKB
G	MAP3K4	mitogen-activated protein kinase kinase kinase 4			IEA	6	161,412,822	161,538,417	RGD:2290271	ENSEMBL
G	MAP3K7	mitogen-activated protein kinase kinase kinase 7			IMP	6	91,223,292	91,297,020	RGD:2290271	UniProtKB
G	MAP3K7	mitogen-activated protein kinase kinase kinase 7			IDA	6	91,223,292	91,297,020	RGD:2290271	UniProtKB
G	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1			IMP	11	77,033,060	77,185,108	RGD:2290271	UniProtKB
G	PTK2B	protein tyrosine kinase 2 beta			IEA	8	27,168,999	27,316,908	RGD:2290271	ENSEMBL
G	TAOK3	TAO kinase 3			IMP	12	118,587,606	118,810,750	RGD:2290271	UniProtKB
G	TLR6	toll-like receptor 6			IDA	4	38,825,325	38,858,438	RGD:2290271	MGI
G	TLR9	toll-like receptor 9			IDA	3	52,255,096	52,260,179	RGD:2290271	BHF-UCL
G	TNF	tumor necrosis factor			IDA	6	31,543,344	31,546,113	RGD:2290271	UniProtKB
G	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator			IMP	18	59,992,520	60,054,943	RGD:2290271	BHF-UCL
G	TRAF2	TNF receptor-associated factor 2			IDA	9	139,780,965	139,821,067	RGD:2290271	UniProtKB
G	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase			IDA	11	36,505,317	36,531,863	RGD:2290271	BHF-UCL
G	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase			NAS	11	36,505,317	36,531,863	RGD:2290271	UniProtKB
G	VANGL2	VANGL planar cell polarity protein 2			IEA	1	160,370,364	160,398,468	RGD:2290271	ENSEMBL
G	ZEB2	zinc finger E-box binding homeobox 2			IEA	2	145,141,942	145,277,958	RGD:2290271	ENSEMBL
positive regulation of p38MAPK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	BMP2	bone morphogenetic protein 2			IDA	20	6,748,745	6,760,910	RGD:2290271	DFLAT
G	VEGFA	vascular endothelial growth factor A			IDA	6	43,737,946	43,754,224	RGD:2290271	UniProtKB
G	XDH	xanthine dehydrogenase			IDA	2	31,557,188	31,637,611	RGD:2290271	UniProtKB
positive regulation of stress-activated MAPK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	CARD9	caspase recruitment domain family, member 9			IDA	9	139,258,408	139,268,133	RGD:2290271	MGI
G	EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2			ISS	2	37,332,281	37,384,190	RGD:2290271	UniProtKB
G	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase			IEA	5	74,632,993	74,657,926	RGD:2290271	ENSEMBL
G	IL26	interleukin 26			IDA	12	68,595,129	68,619,571	RGD:2290271	UniProtKB
G	MID1	midline 1 (Opitz/BBB syndrome)			IMP	X	10,413,350	10,851,809	RGD:2290271	UniProtKB
G	NOD2	nucleotide-binding oligomerization domain containing 2			IDA	16	50,731,050	50,766,987	RGD:2290271	MGI
G	SEMA4C	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C			IDA	2	97,525,473	97,535,735	RGD:2290271	UniProtKB
G	TAOK1	TAO kinase 1			IMP	17	27,717,943	27,878,921	RGD:2290271	UniProtKB
G	TAOK2	TAO kinase 2			IMP	16	29,985,188	30,003,582	RGD:2290271	UniProtKB
G	TAOK3	TAO kinase 3			IMP	12	118,587,606	118,810,750	RGD:2290271	UniProtKB
G	TGFB2	transforming growth factor, beta 2			IDA	1	218,518,676	218,617,961	RGD:2290271	BHF-UCL
regulation of JNK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	AKT2	v-akt murine thymoma viral oncogene homolog 2			IEA	19	40,736,224	40,791,302	RGD:2290271	ENSEMBL
G	COPS5	COP9 signalosome subunit 5			IDA	8	67,955,314	67,974,562	RGD:2290271	UniProtKB
G	DIXDC1	DIX domain containing 1			IBA	11	111,807,927	111,893,308	RGD:2290271	RefGenome
G	EPHB1	EPH receptor B1			IDA	3	134,514,099	134,979,309	RGD:2290271	UniProtKB
G	F2RL1	coagulation factor II (thrombin) receptor-like 1			IDA	5	76,114,833	76,131,140	RGD:2290271	UniProtKB
G	IGF1R	insulin-like growth factor 1 receptor			IDA	15	99,192,761	99,507,759	RGD:2290271	UniProtKB
G	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4			IDA	2	102,314,165	102,511,152	RGD:2290271	UniProtKB
G	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1			ISS	11	45,907,047	45,928,016	RGD:2290271	UniProtKB
G	MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2			IDA	22	51,039,131	51,049,979	RGD:2290271	UniProtKB
G	MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3			ISS	16	1,756,221	1,820,318	RGD:2290271	UniProtKB
G	MAPK9	mitogen-activated protein kinase 9			IEA	5	179,660,594	179,719,071	RGD:2290271	ENSEMBL
G	RAP2A	RAP2A, member of RAS oncogene family			IDA	13	98,086,475	98,120,252	RGD:2290271	UniProtKB
G	SH3RF1	SH3 domain containing ring finger 1			IEA	4	170,015,407	170,192,249	RGD:2290271	ENSEMBL
G	TRAF2	TNF receptor-associated factor 2			IEA	9	139,780,965	139,821,067	RGD:2290271	ENSEMBL
G	TRAF2	TNF receptor-associated factor 2			IEA	9	139,780,965	139,821,067	RGD:2290271	InterPro
regulation of JUN kinase activity
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	CBS	cystathionine-beta-synthase			IEA	21	44,473,301	44,496,472	RGD:2290271	ENSEMBL
G	PPEF2	protein phosphatase, EF-hand calcium binding domain 2			IC	4	76,781,025	76,823,681	RGD:2290271	BHF-UCL
G	TNXB	tenascin XB			IEA	6	32,008,932	32,077,151	RGD:2290271	ENSEMBL
regulation of p38MAPK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	CAV3	caveolin 3			IEA	3	8,775,486	8,788,451	RGD:2290271	ENSEMBL
G	DAB2IP	DAB2 interacting protein			ISS	9	124,329,399	124,547,809	RGD:2290271	UniProtKB
regulation of stress-activated MAPK cascade
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	GREM1	gremlin 1, DAN family BMP antagonist		NOT	ISS	15	33,010,205	33,026,870	RGD:2290271	BHF-UCL
G	GSTP1	glutathione S-transferase pi 1			ISS	11	67,351,066	67,354,124	RGD:2290271	BHF-UCL
G	MAP2K1	mitogen-activated protein kinase kinase 1			TAS	15	66,679,211	66,783,882	RGD:2290271	UniProtKB
G	MAP2K2	mitogen-activated protein kinase kinase 2			TAS	19	4,090,319	4,124,126	RGD:2290271	UniProtKB
G	MAPK1	mitogen-activated protein kinase 1			TAS	22	22,113,946	22,221,970	RGD:2290271	UniProtKB
G	MAPK3	mitogen-activated protein kinase 3			TAS	16	30,125,426	30,134,630	RGD:2290271	UniProtKB
G	NBR1	neighbor of BRCA1 gene 1			ISS	17	41,322,498	41,363,707	RGD:2290271	BHF-UCL
G	PRDX1	peroxiredoxin 1			IEA	1	45,976,707	45,988,562	RGD:2290271	ENSEMBL

Term paths to the root

Path 1
Term	Annotations
biological_process	117092
response to stimulus	27671
cellular response to stimulus	17850
cellular response to stress	2849
stress-activated protein kinase signaling cascade	337
stress-activated MAPK cascade	334
JNK cascade +	248
negative regulation of stress-activated MAPK cascade +	28
p38MAPK cascade +	5
positive regulation of stress-activated MAPK cascade +	69
regulation of stress-activated MAPK cascade +	211
Path 2
Term	Annotations
biological_process	117092
cellular process	80010
single-organism cellular process	49245
cell communication	16198
signal transduction	13710
intracellular signal transduction	4286
intracellular protein kinase cascade	1805
MAPK cascade	986
stress-activated MAPK cascade	334
JNK cascade +	248
negative regulation of stress-activated MAPK cascade +	28
p38MAPK cascade +	5
positive regulation of stress-activated MAPK cascade +	69
regulation of stress-activated MAPK cascade +	211