isotype switching to IgE isotypes - Ontology Report

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ONTOLOGY REPORT - ANNOTATIONS

Term:	isotype switching to IgE isotypes	go back to main search page
Accession:	GO:0048289	browse the term
Definition:	The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:	exact_synonym:	class switch recombination to IgE isotypes; class switching to IgE isotypes; isotype switch recombination to IgE isotypes

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interleukin-4-dependent isotype switching to IgE isotypes
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4		ISO	13	77,026,337	77,050,223	RGD:1624291	RGD
G	Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4		IEA	13	77,026,337	77,050,223	RGD:1600115	ENSEMBL
negative regulation of isotype switching to IgE isotypes
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Bcl6	B-cell CLL/lymphoma 6		ISO	11	79,006,123	79,030,555	RGD:1624291	RGD
G	Bcl6	B-cell CLL/lymphoma 6		IEA	11	79,006,123	79,030,555	RGD:1600115	ENSEMBL
G	Foxp3	forkhead box P3		ISO	X	26,950,006	26,965,329	RGD:1624291	RGD
G	Foxp3	forkhead box P3		IBA	X	26,950,006	26,965,329	RGD:1600115	RefGenome
G	Ndfip1	Nedd4 family interacting protein 1		ISO	18	31,351,538	31,401,736	RGD:1624291	RGD
G	Ndfip1	Nedd4 family interacting protein 1		IEA	18	31,351,538	31,401,736	RGD:1600115	ENSEMBL
positive regulation of isotype switching to IgE isotypes
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Clcf1	cardiotrophin-like cytokine factor 1		ISO	1	206,802,745	206,806,332	RGD:1624291	RGD
G	Il4	interleukin 4		ISO	10	39,074,582	39,080,134	RGD:1624291	RGD
G	Il4	interleukin 4		IEA	10	39,074,582	39,080,134	RGD:1600115	ENSEMBL
G	Stat6	signal transducer and activator of transcription 6, interleukin-4 induced		ISO	7	67,623,534	67,642,283	RGD:1624291	RGD
G	Stat6	signal transducer and activator of transcription 6, interleukin-4 induced		IEA	7	67,623,534	67,642,283	RGD:1600115	ENSEMBL

Term paths to the root

Path 1
Term	Annotations
biological_process	135967
immune system process	6124
leukocyte activation	1882
lymphocyte activation	1639
lymphocyte activation involved in immune response	207
B cell activation involved in immune response	92
isotype switching	76
isotype switching to IgE isotypes	13
interleukin-4-dependent isotype switching to IgE isotypes +	2
negative regulation of isotype switching to IgE isotypes	6
positive regulation of isotype switching to IgE isotypes +	5
regulation of isotype switching to IgE isotypes +	11
Path 2
Term	Annotations
biological_process	135967
metabolic process	36390
nitrogen compound metabolic process	16458
cellular nitrogen compound metabolic process	15301
nucleobase-containing compound metabolic process	14436
nucleic acid metabolic process	12471
DNA metabolic process	2273
DNA recombination	365
somatic cell DNA recombination	135
somatic diversification of immune receptors via germline recombination within a single locus	134
somatic recombination of immunoglobulin gene segments	99
somatic recombination of immunoglobulin genes involved in immune response	78
isotype switching	76
isotype switching to IgE isotypes	13
interleukin-4-dependent isotype switching to IgE isotypes +	2
negative regulation of isotype switching to IgE isotypes	6
positive regulation of isotype switching to IgE isotypes +	5
regulation of isotype switching to IgE isotypes +	11